Genotoxicity and subchronic general toxicity assessments of Lactobacillus curvatus WiKim 38 using Sprague-Dawley rats

Han, Ji-Seok; Back, Seng-Min; Cho, Jae-Woo; Park, Hyojin; Kim, Woo Jin; Park, Seong Hoon; Noh, Jung-Ho; Kim, Yong-Bum; Lee, Byoung‐Seok

doi:10.1016/j.fct.2021.112199

Cited by 6 publications

(2 citation statements)

References 18 publications

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“…To sum up, the concentration of K56, ET-22, and BL-99 (2.62 × 10 11 , 2.62 × 10 11 , 1.88 × 10 11 CFUs/kg BW of mice, respectively) considered the no-observed-adverse-effectlevel (NOAEL) in this study. Our findings were consistent with other equivalent oral repeated toxicity studies of lactic acid bacteria, which have shown that dosing levels ranging from 10 8 to 10 10 CFU/day have no adverse or toxicological effects on experimental rats according to acute or subacute toxicity studies ( Jia et al, 2011 ; Owaga et al, 2014 ; Han et al, 2021 ).…”

Section: Resultssupporting

confidence: 92%

Safety Evaluation of Bifidobacterium lactis BL-99 and Lacticaseibacillus paracasei K56 and ET-22 in vitro and in vivo

Wen

Liu

et al. 2021

Front. Microbiol.

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Probiotics have been reported to play a major role in maintaining the balance of microbiota in host. Consumption of food with probiotics has increased with consumer concerns regarding healthy diets and wellness. Correspondingly, safety evaluation of probiotics for human consumption has become increasingly important in food industry. Herein, we aimed to test the safety of Bifidobacterium lactis BL-99 and Lacticaseibacillus paracasei K56 and ET-22 strains in vitro and in vivo. In results, these strains were found to be negative for mucin degradation and platelet aggregation test. Additionally, the three strains were susceptible to eight antibiotics. In accordance with bacterial reversion mutation (Ames) assay, the tested strains had no genetic mutagenicity. Finally, it was confirmed that there were no dose-dependent mortality and toxicity throughout multidose oral toxicity tests in rats. Our findings demonstrated that B. lactis BL-99 and L. paracasei K56 and ET-22 can achieve the generally recognized as safe (GRAS) status as probiotics in the future.

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Section: Resultssupporting

confidence: 92%

Safety Evaluation of Bifidobacterium lactis BL-99 and Lacticaseibacillus paracasei K56 and ET-22 in vitro and in vivo

Wen

Liu

et al. 2021

Front. Microbiol.

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“…The results that were gathered in the current review established confirm the favorable impact of dietary consumption of probiotics and isoflavones on calcium absorption and bone health. It also showed that probiotics [73] and isoflavones [74] are safe to consume for humans, based on their safety profile according to general toxicity assessments. Furthermore, in terms of bone health, the gut microbiota involves millions of bacteria and can be modified by numerous environmental factors, including diet.…”

Section: Discussionmentioning

confidence: 99%

Probiotics and Isoflavones as a Promising Therapeutic for Calcium Status and Bone Health: A Narrative Review

Harahap

Suliburska

2021

Foods

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Probiotics have potential clinical effects for treating and preventing osteoporosis. Meanwhile, isoflavones have attracted much attention due to their ability to prevent postmenopausal symptoms. Research has established that probiotics and isoflavones can regulate hormones, immune cells, and the gastrointestinal system, acting as links in the gut–bone axis. However, combining the effects of probiotics and isoflavones on calcium status and bone health is a more novel and a still-evolving research area. Lactobacillus and Bifidobacterium are the foremost strains that influence bone health to a significant extent. Among the isoflavones, daidzein, genistein, and the metabolites of genistein (such as equol) stimulate bone formation. It can be concluded that probiotics and isoflavones promote bone health by regulating calcium uptake, gut microbiota, and various metabolic pathways that are associated with osteoblast activity and bone formation. Nevertheless, further experiments of probiotics and isoflavones are still necessary to confirm the association between calcium bioavailability and bone health.

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Safety Evaluation of a Novel Potentially Probiotic Limosilactobacillus fermentum in Rats

Neto

Oliveira

et al. 2023

Probiotics & Antimicro. Prot.

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Genotoxicity and subchronic general toxicity assessments of Lactobacillus curvatus WiKim 38 using Sprague-Dawley rats

Cited by 6 publications

References 18 publications

Safety Evaluation of Bifidobacterium lactis BL-99 and Lacticaseibacillus paracasei K56 and ET-22 in vitro and in vivo

Safety Evaluation of Bifidobacterium lactis BL-99 and Lacticaseibacillus paracasei K56 and ET-22 in vitro and in vivo

Probiotics and Isoflavones as a Promising Therapeutic for Calcium Status and Bone Health: A Narrative Review

Safety Evaluation of a Novel Potentially Probiotic Limosilactobacillus fermentum in Rats

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