Genotoxicity investigations on nanomaterials: Methods, preparation and characterization of test material, potential artifacts and limitations—Many questions, some answers

Landsiedel, Robert; Kapp, Maike Diana; Schulz, Markus; Wiench, Karin; Oesch, Franz

doi:10.1016/j.mrrev.2008.10.002

Cited by 352 publications

(216 citation statements)

References 56 publications

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“…Large differences in reported toxicity of CNPs in the literature are likely a consequence of investigators actually testing different materials, starting materials containing varying amounts of contamination, and variable aggregation of the NPs occurring in the test solution. Carefully characterizing starting materials will enhance comparability of results among laboratories, facilitate interpretations of ecotoxicity results, and help the field to develop standardized ecotoxicity tests for CNPs [37][38][39][40] Residual chemical impurities (organic chemicals or metals) from the synthesis process or from subsequent chemical modifications of CNPs are likely to be present especially for CNTs. Carbon nanotubes are often synthesized by chemical vapor deposition, a process in which nanotubes are formed by passing a hydrocarbon gas over a metal catalyst at an elevated temperature [41,42].…”

Section: Steps In Conducting Ecotoxicity Tests With Cnpsmentioning

confidence: 99%

Methodological considerations for testing the ecotoxicity of carbon nanotubes and fullerenes: Review

Petersen

Henry

2011

Enviro Toxic and Chemistry

114

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Abstract-The recent emergence of manufactured nanoparticles (NPs) that are released into the environment and lead to exposure in organisms has accelerated the need to determine NP toxicity. Techniques for measuring the toxicity of NPs (nanotoxicology) in ecological receptors (nanoecotoxicology) are in their infancy, however, and establishing standardized ecotoxicity tests for NPs are presently limited by several factors. These factors include the extent of NP characterization necessary (or possible) before, during, and after toxicity tests such that toxic effects can be related to physicochemical characteristics of NPs; determining uptake and distribution of NPs within exposed organisms (does uptake occur or are effects exerted at organism surfaces?); and determining the appropriate types of controls to incorporate into ecotoxicity tests with NPs. In this review, the authors focus on the important elements of measuring the ecotoxicity of carbon NPs (CNPs) and make recommendations for ecotoxicology testing that should enable more rigorous interpretations of collected data and interlaboratory comparisons. This review is intended to serve as a next step toward developing standardized tests that can be incorporated into a regulatory framework for CNPs. Environ. Toxicol. Chem.

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Section: Steps In Conducting Ecotoxicity Tests With Cnpsmentioning

confidence: 99%

Methodological considerations for testing the ecotoxicity of carbon nanotubes and fullerenes: Review

Petersen

Henry

2011

Enviro Toxic and Chemistry

114

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“…However, more in vivo studies are required to fully understand the mechanism of TiO 2 nanoparticles toxicity. Likewise, more caution should be considered for toxicity assessment of nanoparticles because of the limitations and potential artifacts of the results (Doak, et al, 2012, Landsiedel et al, 2009. This study provides a better insight into the potential toxicity of nanoparticles with respect to their physiochemical characteristics.…”

Section: Most Of the Toxicological Results On Nps Have Been Generatedmentioning

confidence: 94%

In vitro cytotoxicity and genotoxicity studies of titanium dioxide (TiO2) nanoparticles in Chinese hamster lung fibroblast cells

Hamzeh

Sunahara

2013

Toxicology in Vitro

124

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/npsi/ctrl?lang=en http://nparc.cisti-icist.nrc-cnrc.gc.ca/npsi/ctrl?lang=fr Access and use of this website and the material on it are subject to the Terms and Conditions set forth at http://nparc.cisti-icist.nrc-cnrc.gc.ca/npsi/jsp/nparc_cp.jsp?lang=en NRC Publications Archive Archives des publications du CNRCThis publication could be one of several versions: author's original, accepted manuscript or the publisher's version. / La version de cette publication peut être l'une des suivantes : la version prépublication de l'auteur, la version acceptée du manuscrit ou la version de l'éditeur. For the publisher's version, please access the DOI link below./ Pour consulter la version de l'éditeur, utilisez le lien DOI ci-dessous.http://dx.doi.org/10. 1016/j.tiv.2012.12.018 Toxicology in Vitro, 27, 2, pp. 864-873, 2012-12-28 In vitro cytotoxicity and genotoxicity studies of titanium dioxide (TiO2) nanoparticles in Chinese hamster lung fibroblast cells Hamzeh, Mahsa; Sunahara, Geoffrey I. Therefore, our objective was to investigate the cytotoxicity and genotoxicity of commercially available TiO 2 nanoparticles with respect to their selected physicochemical properties, as well as the role of surface coating of these nanoparticles. While all types of tested TiO 2 samples decrease cell viability in a mass-based concentration-and size-dependent manner, the polyacrylate-coated nano-TiO 2 product was only cytotoxic at higher concentrations. A similar pattern of response was observed for induction of apoptosis/necrosis, and no DNA damage was detected in the polyacrylate-coated nano-TiO 2 model. Given the increasing production of TiO 2 nanoparticles, toxicological studies should take into account the physiochemical properties of these nanoparticles that may help researchers to develop new nanoparticles with minimum toxicity.

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“…DNA damage assessed by classic assays is positive in most studies conducted to date. 417 Inefficient DNA repair may be the primary risk for nanoparticle-induced hereditary and carcinogenic toxicity. DNA damage is the consequence of nanoparticles' 'double hits' on DNA.…”

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confidence: 99%

Perturbation of physiological systems by nanoparticles

et al. 2014

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Nanotechnology is having a tremendous impact on our society. However, societal concerns about human safety under nanoparticle exposure may derail the broad application of this promising technology. Nanoparticles may enter the human body via various routes, including respiratory pathways, the digestive tract, skin contact, intravenous injection, and implantation. After absorption, nanoparticles are carried to distal organs by the bloodstream and the lymphatic system. During this process, they interact with biological molecules and perturb physiological systems. Although some ingested or absorbed nanoparticles are eliminated, others remain in the body for a long time. The human body is composed of multiple systems that work together to maintain physiological homeostasis. The unexpected invasion of these systems by nanoparticles disturbs normal cell signaling, impairs cell and organ functions, and may even cause pathological disorders. This review examines the comprehensive health risks of exposure to nanoparticles by discussing how nanoparticles perturb various physiological systems as revealed by animal studies. The potential toxicity of nanoparticles to each physiological system and the implications of disrupting the balance among systems are emphasized.

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Genotoxicity investigations on nanomaterials: Methods, preparation and characterization of test material, potential artifacts and limitations—Many questions, some answers

Cited by 352 publications

References 56 publications

Methodological considerations for testing the ecotoxicity of carbon nanotubes and fullerenes: Review

Methodological considerations for testing the ecotoxicity of carbon nanotubes and fullerenes: Review

In vitro cytotoxicity and genotoxicity studies of titanium dioxide (TiO2) nanoparticles in Chinese hamster lung fibroblast cells

Perturbation of physiological systems by nanoparticles

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