Genotoxicity of chemical and physical agents in cultured human tissues and cells

Weston, Ainsley; Plummer, Simon; Grafström, Roland C.; Trump, Benjamin F.; Harris, Curtis C.

doi:10.1016/0278-6915(86)90156-0

Cited by 7 publications

(2 citation statements)

References 31 publications

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“…Formaldehyde is very toxic to humans since it is highly reactive and denatures biologic macromolecules such as nucleic acid and proteins (Squire and Cameron, 1984;Craft et al, 1987;Weston et al, 1986). Formaldehyde may be associated with various diseases including atopic dermatitis, bronchial asthma, and cancer (Morgan, 1997;Feron et al, 1991), as well as sick building syndrome (Kim et al, 2002;Salvi, 2001).…”

Section: Introductionmentioning

confidence: 99%

Formaldehyde Concentrations in Ambient Air in Urban and Rural Areas in Gunma Prefecture, Japan

Tago

Kimura

Kozawa

et al. 2005

Water Air Soil Pollut

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We measured formaldehyde concentrations in ambient air at urban (Isesaki) and rural (Annaka) sites in Gunma Prefecture, Japan from June 1998 to March 2003. Measurements were carried out once in a month to obtain daily mean formaldehyde concentrations. At both the sites, mean concentrations of formaldehyde were significantly higher from April to September (summer) than from October to March (winter). Formaldehyde concentrations in Annaka were essentially as high as those in Isesaki in summer, but were significantly lower in winter. At both the sites, concentrations of formaldehyde and oxidants correlated significantly with one another in the summer; correlation coefficients in Annaka and Isesaki were 0.82 and 0.64, respectively. The fraction of formaldehyde formed photochemically based on concentrations of benzene was calculated to be as high as 80% in both the sites in summer. The results suggested that formaldehyde concentrations were high even in rural air, reflecting photochemical reactions rather than automobile exhaust.

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Section: Introductionmentioning

confidence: 99%

Formaldehyde Concentrations in Ambient Air in Urban and Rural Areas in Gunma Prefecture, Japan

Tago

Kimura

Kozawa

et al. 2005

Water Air Soil Pollut

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show abstract

“…The toxic effects of formalin on cells has frequently been estimated by measuring nucleic acid and protein related parameters (Grafstrom et al 1983;Weston et al 1986;Craft et al 1987;Grafstrom 1990). Formalin can affect cellular metabolism both as an exogenous xenobiotic (i.e.…”

Section: Introductionmentioning

confidence: 99%

Untitled

Ghioni¹,

Tocher²,

Sargent³

1998

Fish Physiology and Biochemistry

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The effects of sub-lethal doses of dichlorvos and formalin, antimicrobial/parasitic agents used in aquaculture, on lipid composition and metabolism of rainbow trout skin cells in primary culture were investigated. Both dichlorvos and, especially, formalin appeared to significantly inhibit Δ9 and Δ6 desaturase.Changes in the distribution of radioactivity between individual phospholipid classes was also influenced by formalin and dichlorvos, and this may be related to changes in desaturase activity. This study has shown that topically active agents used in aquaculture, formalin and dichlorvos, had a range of effects on the rainbow trout skin cell cultures that may affect cell proliferation and lipid and fatty acid metabolism. Both agents significantly inhibited desaturation of fatty acids, particularly of 18:2n-6 to 20:4n-6 and, as 20:4n-6 is a major eicosanoid precursor in fish and considering the importance of eicosanoids in the biochemistry of skin ,it is suggested that these agents may have direct effects on fish skin that may have important consequences for fish health in general.3

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Review of the genotoxicity of formaldehyde

Harris

1988

Mutation Research/Reviews in Genetic Toxicology

130

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Genotoxicity of chemical and physical agents in cultured human tissues and cells

Cited by 7 publications

References 31 publications

Formaldehyde Concentrations in Ambient Air in Urban and Rural Areas in Gunma Prefecture, Japan

Formaldehyde Concentrations in Ambient Air in Urban and Rural Areas in Gunma Prefecture, Japan

Untitled

Review of the genotoxicity of formaldehyde

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