Genotoxicity of nanomaterials in vitro: treasure or trash?

Haase, Andrea; Luch, Andreas

doi:10.1007/s00204-016-1825-5

Cited by 9 publications

(6 citation statements)

References 24 publications

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“…Although some studies were already conducted, there is still a big uncertainty regarding the effects of engineered nanomaterials on environment and human health. Recently, due to the proliferation of nanotechnology in several industries, particularly food additives and packaging, more publications are addressing this topic [30,71,[73][74][75]. The production of nanomaterials and the asphalt binder modification are important phases where exposure can be significant.…”

Section: Modification Of the Asphalt Binder With Nanomaterialsmentioning

confidence: 99%

A Review of Nanomaterials’ Effect on Mechanical Performance and Aging of Asphalt Mixtures

et al. 2019

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This review addresses the effects of the modifications with nanomaterials, particularly nanosilica, nanoclays, and nanoiron, on the mechanical performance and aging resistance of asphalt mixtures. The desire for high-performance and long-lasting asphalt pavements significantly pushed the modification of the conventional paving asphalt binders. To cope with such demand, the use of nanomaterials for the asphalt binder modification seems promising, as with a small amount of modification an important enhancement of the asphalt mixture mechanical performance can be attained. Several studies already evaluated the effects of the modifications with nanomaterials, mostly focusing on the asphalt binder properties and rheology, and the positive findings encouraged the study of modified asphalt mixtures. This review focuses on the effects attained in the mechanical properties of the asphalt mixtures, under fresh and aged conditions. Generally, the effects of each nanomaterial were evaluated with the current state-of-art tests for the characterization of mechanical performance of asphalt mixtures, such as, permanent deformation, stiffness modulus, fatigue resistance, indirect tensile strength, and Marshall stability. Aging indicators, as the aging sensitivity, were used to evaluate the effects in the asphalt mixture’s aging resistance. Finally, to present a better insight into the economic feasibility of the analyzed nanomaterials, a simple cost analysis is performed.

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Section: Modification Of the Asphalt Binder With Nanomaterialsmentioning

confidence: 99%

A Review of Nanomaterials’ Effect on Mechanical Performance and Aging of Asphalt Mixtures

et al. 2019

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Section: Modification Of the Asphalt Binder With Nanomaterialsmentioning

confidence: 99%

Nano-Modified Asphalt Binders and Mixtures to Enhance Pavement Performance

2020

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“…7,8 Many reports illustrated that nanomaterials could elicit genotoxicity associated with cell death. 9,10 However, there are few studies determined to investigate the alteration of epigenetic integrity upon nanomaterials exposure under lower concentration. 11 As one of epigenetics, histone modifications can significantly modulate gene expression and play a role in tumor.…”

Section: Introductionmentioning

confidence: 99%

<p>Anticancer Effects of Zinc Oxide Nanoparticles Through Altering the Methylation Status of Histone on Bladder Cancer Cells</p>

Zhang

Liu

et al. 2020

IJN

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Purpose: Zinc oxide nanoparticles (nZnO) have been widely used in the medicine field. Numerous mechanistic studies for nZnO's anticancer effects are merely performed under high concentration exposure. However, possible anticancer mechanisms of epigenetic dysregulation induced by low doses of nZnO are unclear. Methods: nZnO were characterized and bladder cancer T24 cells were treated with nZnO for 48 hrs at different exposure concentrations. Cell cycle, apoptosis, cell migration and invasion were determined. We performed qRT-PCR, Western blot and chromatin immunoprecipitation to detect the mRNA and protein levels of signaling pathway cascades for histone modification. Results: In this study, we investigated the potential anticancer effects and mechanisms of nZnO on histone modifications in bladder cancer T24 cells upon low-dose exposure. Our findings showed that low concentrations of nZnO resulted in cell cycle arrest at S phase, facilitated cellular late apoptosis, repressed cell invasion and migration after 48 hrs exposure. These anticancer effects could be attributed to increased RUNX3 levels resulting from reduced H3K27me 3 occupancy on the RUNX3 promoter, as well as decreased contents of histone methyltransferase EZH2 and the trimethylation of histone H3K27. Our findings reveal that nZnO are able to enter into the cytoplasm and nucleus of T24 cells. Additionally, both particles and ions from nZnO may jointly contribute to the alteration of histone methylation. Moreover, sublethal nZnO-conducted anticancer effects and epigenetic mechanisms were not associated with oxidative stress or DNA damage. Conclusion: We reveal a novel epigenetic mechanism for anticancer effects of nZnO in bladder cancer cells under low-dose exposure. This study will provide experimental basis for the toxicology and cancer therapy of nanomaterials.

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Genotoxicity of nanomaterials in vitro: treasure or trash?

Cited by 9 publications

References 24 publications

A Review of Nanomaterials’ Effect on Mechanical Performance and Aging of Asphalt Mixtures

A Review of Nanomaterials’ Effect on Mechanical Performance and Aging of Asphalt Mixtures

Nano-Modified Asphalt Binders and Mixtures to Enhance Pavement Performance

<p>Anticancer Effects of Zinc Oxide Nanoparticles Through Altering the Methylation Status of Histone on Bladder Cancer Cells</p>

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