Genotype and retention of the ejaculatory reflex in castrated male mice

McGill, Thomas E.; Manning, Aubrey

doi:10.1016/s0003-3472(76)80063-2

Cited by 72 publications

(21 citation statements)

References 17 publications

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“…The expression of sexual behavior in adult male mammals, including mice, is thought to depend on both the perinatal ("organizational") [23,24] and the adult ("activational") [25,26] actions of testosterone, or its estrogenic metabolites, in the brain. It seems unlikely that the observed deficits in mutant males' coital performance can be explained by deficiencies in either of these steroid-dependent processes.…”

Section: Discussionmentioning

confidence: 99%

Effect of a Null Mutation of the c-fos Proto-Oncogene on Sexual Behavior of Male Mice1

Baum

Brown

Kica

et al. 1994

Biology of Reproduction

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Sexual behavior was observed in male mice that were homozygous for a null mutation of the c-fos proto-oncogene, as well as in heterozygous mutants and wild-type controls. The onset of mounting was slower and the subsequent mounting rate was significantly lower in homozygous mutants than in either group of controls. Even so, a similar percentage of males of each genotype achieved ejaculation, and ejaculation latencies were equivalent in these mice. Likewise, in males that intromitted, the intromission efficiency and the number of intravaginal thrusts/intromission were similar among the three genotypes. The nuclear protein product (Fos) of c-fos was visualized immunocytochemically in the brains of heterozygous male mice 1 h after they exhibited a series of mounts, with or without intromission, leading to an ejaculation. As in the male of several other rodent species, nuclear Fos immunoreactivity was augmented in neurons of limbic and midbrain regions thought to convey olfactory/vomeronasal and genital/somatosensory information, respectively, to the medial preoptic area following contact with an estrous female. One interpretation of our behavioral results is that in the absence of normal neuronal c-fos expression, sensory stimuli that impinge on the male brain during mating lose their ability to initiate a cascade of further gene transcription events that otherwise control the rate at which a male reorients towards and mounts an estrous female during an ejaculatory series. Alternatively, the c-fos null mutation may disrupt normal neural development, leading to a structural change that mediates the observed deficit in mounting capacity.

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Section: Discussionmentioning

confidence: 99%

Effect of a Null Mutation of the c-fos Proto-Oncogene on Sexual Behavior of Male Mice1

Baum

Brown

Kica

et al. 1994

Biology of Reproduction

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“…Synthetic androgens (5α-androstanediols) that can be aromatized to E, but not 5α-reduced to DHT, were even more effective than T in restoring sexual behavior (Ogawa et al, 1996). One strain, the B6D2F1 hybrid, recovered the ability to copulate about 3 weeks after castration without exogenous hormones (McGill and Manning, 1976). These "continuer" males depend on E 2 ; although the source of the E 2 is not clear, it may be produced in the brain (Sinchak et al, 1996).…”

Section: Hormonal Factors In the Activation Of Male Mouse Mating Behamentioning

confidence: 99%

Sexual behavior in male rodents

Hull

Domínguez

2007

Hormones and Behavior

395

272

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The hormonal factors and neural circuitry that control copulation are similar across rodent species, although there are differences in specific behavior patterns. Both estradiol (E) and dihydrotestosterone (DHT) contribute to the activation of mating, although E is more important for copulation and DHT for genital reflexes. Hormonal activation of the medial preoptic area (MPOA) is most effective, although implants in the medial amygdala (MeA) can also stimulate mounting in castrates. Chemosensory inputs from the main and accessory olfactory systems are the most important stimuli for mating in rodents, especially in hamsters, although genitosensory input also contributes. Dopamine agonists facilitate sexual behavior, and serotonin (5-HT) is generally inhibitory, though certain 5-HT receptor subtypes facilitate erection or ejaculation. Norepinephrine agonists and opiates have dose-dependent effects, with low doses facilitating and high doses inhibiting behavior.

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“…Behavioral changes have also been observed in hybrids, such as the temperament differences commonly reported between hinnies (donkey mother and horse father) and mules (horse mother and donkey father) (Gray, 1972). In the laboratory, the reciprocal breeding of various inbred and outbred rodent strains and species has been extremely useful in screening for parent-of-origin effects on behavioral and physiological phenotypes such as emotional reactivity (Calatayud & Belzung, 2001;Carola, Frazzetto, & Gross, 2006;Roy, Merali, Poulter, & Anisman, 2007), maternal care (Calatayud, Coubard, & Belzung, 2004;Carola et al, 2008;Shoji & Kato, 2009), infanticide (Perrigo et al, 1993), aggression (Carlier, Roubertoux, & Pastoret, 1991;Platt & Maxson, 1989), sex (McGill & Manning, 1976), forced ethanol intake (Gabriel & Cunningham, 2008), calcium taste preference (Tordoff, Reed, & Shao, 2008), activity (Dohm, Richardson, & Garland, 1994;Massett & Berk, 2005;Price & Loomis, 1973), cerebellar development (Cooper, Benno, Hahn, & Hewitt, 1991), peripheral nerve conductivity (Hegmann & White, 1973), central estrogen receptor a distribution (Kramer, Carr, Schmidt, & Cushing, 2006), and puberty onset (Zhou et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Parent‐of‐origin and trans‐generational germline influences on behavioral development: The interacting roles of mothers, fathers, and grandparents

Curley

Mashoodh

2010

Developmental Psychobiology

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Mothers and fathers do not contribute equally to the development of their offspring. In addition to the differential investment of mothers versus fathers in the rearing of offspring, there are also a number of germline factors that are transmitted unequally from one parent or the other that contribute significantly to offspring development. This article shall review four major sources of such parent-of-origin effects. Firstly, there is increasing evidence that genes inherited on the sex chromosomes including the nonpseudoautosomal part of the Y chromosome that is only inherited from fathers to sons, contribute to brain development and behavior independently of the organizing effects of sex hormones. Secondly, recent work has demonstrated that mitochondrial DNA that is primarily inherited only from mothers may play a much greater than anticipated role in neurobehavioral development. Thirdly, there exists a class of genes known as imprinted genes that are epigenetically silenced when passed on in a parent-of-origin specific manner and have been shown to regulate brain development and a variety of behaviors. Finally, there is converging evidence from several disciplines that environmental variations experienced by mothers and fathers may lead to plasticity in the development and behavior of offspring and that this phenotypic inheritance can be solely transmitted through the germline. Mechanistically, this may be achieved through altered programming within germ cells of the epigenetic status of particular genes such as retrotransposons and imprinted genes or potentially through altered expression of RNAs within gametes.

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Genotype and retention of the ejaculatory reflex in castrated male mice

Cited by 72 publications

References 17 publications

Effect of a Null Mutation of the c-fos Proto-Oncogene on Sexual Behavior of Male Mice1

Effect of a Null Mutation of the c-fos Proto-Oncogene on Sexual Behavior of Male Mice1

Sexual behavior in male rodents

Parent‐of‐origin and trans‐generational germline influences on behavioral development: The interacting roles of mothers, fathers, and grandparents

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