Genotype distribution and the relative risk factors for human papillomavirus in Urumqi, China

Abstract

The aim of this study was to investigate human papillomavirus (HPV) infection and HPV genotype distributions in Urumqi, Xinjiang, China. The related risk factors for high-risk HPV infection was also analyzed. A stratified cluster sampling method was used for the population-based cervical cancer screening of women aged 18–69 years in the Urumqi Saybagh district. Exfoliated cervical cell samples were collected for liquid-based cytology detection and HPV genotyping DNA microarrays. Education level, number of sexual partners, condom use and occupation were used in the multivariate analysis model. The HPV infection rate of women working in service industries was significantly higher compared with those of white-collar workers, community residents and migrant workers. The 35–44-year-old migrant worker group had the highest HPV infection rates among all of the groups in the three different age ranges. The number of marriages, education level, smoking history, number of abortions, use of condoms, number of sexual partners, number of sexual partners in the past five years and occupation were all associated with female HPV infection rate (P<0.05). The 35–44-year-old women were the age group with the highest HPV infection rate. The HPV infection rate of females in service industries was the highest. Education level and condom use were protective factors of HPV infection, while the number of sexual partners and occupation were risk factors for HPV infection.

Prevalence of high‐risk human papillomavirus infection among women in Shaanxi province of China: A hospital‐based investigation

“…Additionally, the HPV infection conditions in China varied in different provinces and cities . However, HPV‐16, HPV‐58, and HPV‐52 were the top three most common types in most regions of China . The present study showed that the HPV infection rate among women in Shaanxi province was 30.21%, the HR‐HPV infection rate was 26.73%, and the five most common HR‐HPV types were HPV‐16, HPV‐58, HPV‐52, HPV‐31, and HPV‐18, indicating that HPV‐52 and HPV‐58 might have a higher prevalence rate in China than HPV‐18, which was more common in other countries in the world …”

Status of Human Papillomavirus Infection in the Ethnic Population in Yunnan Province, China

“…The HR-HPV prevalence in the Han women was in line with the previously reported infection rate for Qujing City, Yunnan (8.3%), and the Autonomous Tibet (8.0%) prefecture [ 26 , 33 ]. However, the HR-HPV prevalence in the Hani women was higher compared with other ethnic minority groups in China, such as the Uyghur (7.3%) [ 34 ] and Maonan (7.6%) group, [ 35 ] but lower than Tibetan (26.2%) and Han (16.6%) groups in Northwestern Yunnan. However, the reported HR-HPV prevalence rates in Naxi group (11.4%) in Northwestern Yunnan [ 11 ], Zhejiang (10.2%), and Shanxi (12.2%) are in line with our observations [ 29 , 30 ].…”

Elevated Expression of Programmed Death-1 and Programmed Death Ligand-1 Negatively Regulates Immune Response against Cervical Cancer Cells

“…As the development of tumor immunology and molecular biology, biological treatment has become the fourth treatment method for malignant tumors [ 2 ]. The incidence of cervical cancer in Xinjiang Uygur women is significantly higher than that in women of other ethnic groups, with an average age of onset at 43 years old [ 3 ]. In Xinjiang Autonomous Region, cervical cancer severely threatens the health and life quality of Uygur women and has become an important public health problem [ 4 ].…”