Genotype distribution and transmission of hepatitis C virus (HCV) in French haemodialysed patients

Bouchardeau, Françoise; Chauveau, P; Am, Couroucé; Poignet, Jean-Louis

doi:10.1093/ndt/10.12.2250

Cited by 11 publications

(6 citation statements)

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“…There are few reports regarding the distribution of HCV (sub)types in dialysis patients and all of them con cern small groups of patients [34][35][36][37], Our results are dif ferent from those of Lee et al [34], who observed a high frequency of genotype lb among HD patients in Korea. The predominance of HCV subtype lb was also observed in French HD individuals [35].…”

Section: Discussioncontrasting

confidence: 99%

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Molecular Epidemiology of Hepatitis C Virus Infection in Dialysis Patients

Fabrizi

Lunghi

Pagliari³

et al. 1997

Nephron

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There are very few data on the molecular biology of hepatitis C virus (HCV) infection in dialysis patients. 101 patients undergoing dialysis treatment in 4 units in the Lombardy, northern Italy, were analyzed by RT-PCR for HCV viremia, by line probe assay technology for HCV genotyping and by a serological analysis for detecting type-specific antibodies. 61 of 101 (60%) patients showed detectable HCV RNA in serum; HCV genotype 2a was dominant (30/ 53 = 57%), followed by HCV genotype lb (20/53 = 37%). There was no relationship between HCV genotyping and the clinical or demographic features of the patients. The antibody response toward the c33-c, cl00-3, and 5-1-1 antigens was more frequent in HCV genotype lb compared with genotype 2a (p = 0.046, p = 0.001 and p = 0.0001, respectively). The antibody levels to NS-3 and NS-4 HCV proteins were significantly higher in patients with HCV genotype lb in comparison with HCV 2a-infected individuals (p = 0.0001). There was a high level (82%) of agreement between HCV genotyping by RT-PCR and the assessment of type-specific antibodies by serological analysis; further, it was possible to detect type-specific antibodies in 6 of 22 (27%) patients in whom PCR amplification was unsuccessful. In conclusion, HCV subtype 2a was dominant in our population of HCV-infected dialysis patients, dialysis patients infected by different genotypes showed similar demographic and clinical characteristics, the antibody response toward the NS-3- and NS-4-related antigen of HCV was genotype dependent. There was a high level of agreement between HCV genotyping by RT-PCR and the detection of type-specific antibodies by serological analysis. As significant biological differences may exist among HCV strains, the assessment of HCV types may be very useful in the routine clinical activity of nephrologists in dialysis units.

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Section: Discussioncontrasting

confidence: 99%

“…The predominance of HCV subtype lb was also observed in French HD individuals [35]. Hadiwandowo et al [36] reported the distribution of HCV genotypes in HD pa tients in China and concluded that the dominant HCV genotype was la.…”

Section: Discussionmentioning

confidence: 85%

Molecular Epidemiology of Hepatitis C Virus Infection in Dialysis Patients

Fabrizi

Lunghi

Pagliari³

et al. 1997

Nephron

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“…In Germany, 77.6% of patients receiving HD are genotype 1 [4]. Although genotype 1a is prevalent in the general population, genotype 1b is more prevalent in patients undergoing HD in the Netherlands [11], Mexico [44], Morocco [45], and France [46]; genotype 2a in Italy [47]; genotypes 1a and 1b in Israel [48] and Indonesia [21]; and genotype 1 in Canada [49]. We may thus conclude that genotypes 1 and 2 are more prevalent in North America and Europe (60%-70%), genotype 3 is more prevalent in the Far East, Asia, and Australia, genotype 4 is more prevalent in Africa and the Middle East, genotype 5 is more prevalent in South Africa, and genotype 6 is more prevalent in Hong Kong.…”

Section: Discussionmentioning

confidence: 99%

Distribution of HCV Genotypes in Patients with End-Stage Renal Disease According to Type of Dialysis Treatment

et al. 2006

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The objective of this study was to investigate the effects of types of dialysis treatments on hepatitis C virus infection and the epidemiologic properties of hepatitis C virus (HCV) infection at three Baskent University hospitals, in Ankara, Adana, and Izmir, Turkey, in 655, 326, and 118 patients with end-stage renal disease, respectively. One hundred thirty patients with HCV viremia among 271 patients with end-stage renal disease seropositive for HCV were included in this cross-sectional study. HCV RNA-positive patients were classified according to the renal replacement therapies (hemodialysis or continuous ambulatory peritoneal dialysis), and viral load, transaminase levels, and distribution of genotypes were compared between these subgroups. In the continuous ambulatory peritoneal dialysis group, 26 of 165 patients (16%) were serum anti-HCV positive, and 11 of 26 patients (42%) were serum HCV RNA positive. Twenty-six percent of the patients undergoing hemodialysis were anti-HCV positive, and 49% were HCV RNA positive. The prevalence of genotype 1b was 68% and 73% for patients in the continuous ambulatory peritoneal dialysis and hemodialysis groups, respectively. No significant differences were found between the genotype 1b and the non-1b groups or between different dialysis types with regard to age and sex and serum aspartate transaminase, alanine aminotransferase, and HCV RNA levels. We conclude that HCV seropositivity may differ between different types of dialysis treatments, although viral load and genotypes may be similar in persons with end-stage renal disease and those without.

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“…Among 236 patients with HCV infection in Belarus, 127 (53.8%) and 58 (28.8%) were found with genotypes 1b and 3a, respectively (18). A study among French hemodialyzed patients reported a rate of 77% for genotype 1b (19). Subtype 1b (54%) had the highest frequency in Vienna, Austria, and surrounding areas (20).…”

Section: Discussionmentioning

confidence: 99%