Distribution of HCV Genotypes in Patients with End-Stage Renal Disease According to Type of Dialysis Treatment

Abstract

The objective of this study was to investigate the effects of types of dialysis treatments on hepatitis C virus infection and the epidemiologic properties of hepatitis C virus (HCV) infection at three Baskent University hospitals, in Ankara, Adana, and Izmir, Turkey, in 655, 326, and 118 patients with end-stage renal disease, respectively. One hundred thirty patients with HCV viremia among 271 patients with end-stage renal disease seropositive for HCV were included in this cross-sectional study. HCV RNA-positive patients were classified according to the renal replacement therapies (hemodialysis or continuous ambulatory peritoneal dialysis), and viral load, transaminase levels, and distribution of genotypes were compared between these subgroups. In the continuous ambulatory peritoneal dialysis group, 26 of 165 patients (16%) were serum anti-HCV positive, and 11 of 26 patients (42%) were serum HCV RNA positive. Twenty-six percent of the patients undergoing hemodialysis were anti-HCV positive, and 49% were HCV RNA positive. The prevalence of genotype 1b was 68% and 73% for patients in the continuous ambulatory peritoneal dialysis and hemodialysis groups, respectively. No significant differences were found between the genotype 1b and the non-1b groups or between different dialysis types with regard to age and sex and serum aspartate transaminase, alanine aminotransferase, and HCV RNA levels. We conclude that HCV seropositivity may differ between different types of dialysis treatments, although viral load and genotypes may be similar in persons with end-stage renal disease and those without.

Hepatitis C infection in hemodialysis patients: A review

“…In developed countries, the prevalence of anti-HCV seropositivity among patients on maintenance HD ranges between 5% and 60%. Patients on HD are at high risk for HCV, with frequency of infection several times higher than that in non-uremic patients [1] . The spread of HCV in HD units is declining, but the prevalence of HCV in HD patients remains high [1] .…”

“…Patients on HD are at high risk for HCV, with frequency of infection several times higher than that in non-uremic patients [1] . The spread of HCV in HD units is declining, but the prevalence of HCV in HD patients remains high [1] . Several observational studies have demonstrated a significant and independent relationship between anti-HCV seropositive status and lower survival rate in patients with end-stage renal disease (ESRD).…”

“…HCV genotypes 1, 4, 5, and 6 are more resistant to treatment and require longer courses of therapy. One study identified HCV genotype 1b as the most prevalent subtype in patients receiving HD or continuous ambulatory peritoneal dialysis in Turkey [1] . In study of Perez et al [30] reported findings that HCV genotype 1a was the most prevalent subtype in patients receiving HD, with genotype 1b the next most frequent, followed by genotype 3, and other less prevalent genotypes (genotypes 2, 4, and 5).…”

Distribution of Hepatitis C Virus Genotypes among Patients with Chronic Hepatitis C Infection in Akdeniz University Hospital, Antalya, Turkey: A Five-Year Evaluation

“…Antalya'nın da, dünyada çok ziyaret edilen şehirlerden biri olması ve ayrıca göç alması 29 Bu çalışmada, HCV viral yük değerleri ve cinsiyet dağılımı açısından genotip 1 ve diğer genotiplerle enfekte hastalar arasında anlamlı bir fark saptanmamıştır. Benzer şekilde, kronik HCV enfeksiyonu olan hastalarda HCV genotiplerindeki farklılık ile cinsiyet dağı-lımı ve HCV-RNA düzeyleri arasında ilişki olmadığı daha önce yapılan çalışmalarda da bildirilmiştir 13,18,25,30,31 . Buna karşın çalışmamızda, genotip 1 ile enfekte hastaların yaş ortalaması diğer genotiplerle enfekte hastalara göre yüksek bulunmuştur (p< 0.001).…”

Genotype Distribution And 5' Utr Nucleotide Changes In Hepatitis C Virus

“…Japonya'da genotip 1b HCV enfeksiyonlarının %70'den fazlasını oluşturmaktadır (9). Türkiye'de yapılan HCV genotip çalışmalarında HCV infeksiyonlarının yaklaşık %90'ı genotip 1 olarak bulunmuştur, bunların da büyük çoğunluğu tip 1b olup, tip 2, 3 ve 4 HCV infeksiyonlarına da daha az sık-lıkla rastlanmaktadır (10)(11)(12)(13)(14)(15). HCV genomunda çeşitli mutasyonlar görülmekte ve buna bağlı türümsüler (Quasispecies) ortaya çıkmaktadır.…”