Genotype distribution of human papilloma virus among women with genital warts biopsies in southern Khorasan, eastern Iran

Moossavi, Maryam; Fereidouni, Mohammad; Zardast, Mahmoud; Khazaei, Zohreh; Ghanbarzadeh, Nahid

doi:10.1016/j.mgene.2020.100720

Cited by 3 publications

(5 citation statements)

References 28 publications

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“…Moreover, the pattern of some types was changing over 3 years; types 11 and 42 declined and shifted to increasing of type 54. This finding is reasonable with minor differences from the result of Mousavi et al [ 31 ].…”

Section: Discussionsupporting

confidence: 89%

“…According to our findings, HPV types 6, 11, 42, and 54 were the most prevalent LR-HPV types; however, HPV types 16 and 39 were prevalent HR-HPV types detected. There are limited studies around Iran that worked on genital warts; almost most of them reported HPV-6 as the leading cause of genital warts [ 30 , 31 ]. Although there were studies that report the dominance of type 11 [ 29 , 32 ], the sample size and methodology affect these figures.…”

Section: Discussionmentioning

confidence: 99%

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Investigation of frequency and typing of human papillomavirus among genital warts using a reverse dot blot hybridization approach

et al. 2022

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Background Human papillomavirus (HPV) is the most common sexually transmitted infection worldwide, affecting about 80% of women up to the age of 50. The persistent infection of high risk-HPV types (HR-HPV) is the leading cause of cervical cancer, the fourth most common cancer of women. Therefore, we aimed to evaluate the frequency and typing of HPV in the genital lesions in the Iranian population. Methods This descriptive-analytic study was conducted on a population in the South-Khorasan province of Iran. All of the participants were sexually active and were checked for evident cervical warts. Biopsy samples were collected from various lesions, and all samples were tested for detection and genotyping of HPV using a reverse dot blot hybridization method (HPV direct flow CHIP). Results In overall, 370 samples were evaluated; 10 cases (2.7%) were male and the rest were female. The mean age of patients was 33.3 ± 8.5 years, of which 48.1% were in the age range from 25 to 36 years. Among the samples, 345 (93.2%) were positive for HPV-DNA; the low risk HPV types (LR-HPV) and HR-HPV were identified among 80.9% and 15.5% of tissue samples, respectively. Among the LR-HPV, HPV-6, 11, 42 and 54 were the most common genotypes, and HPV-16 and 39 were prevalent HR-HPV types detected. The number of pregnancies, marriage age, and partner infection were not significantly related to the HPV types. Types 42 had a declining pattern toward aging, and HPV-11 was increasing toward aging. Conclusion The number of samples with HR-HPV was rather high. Due to the greater frequency of infection in the age range of 25–35 years, it is advised that all individuals referred to gynecological clinics at gestational age be tested for HPV types.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Investigation of frequency and typing of human papillomavirus among genital warts using a reverse dot blot hybridization approach

et al. 2022

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“…A study in South-Eastern of Iran revealed HPV prevalence of 47% in the HR-group, 34% in the LR-group, and 19% in the potential high-risk group, with HPV-6 being the most predominant LR-HPV (14.7%) [ 33 ]. In another study in Eastern of Iran, the most prevalent LR-HPV types were HPV-6, 89, 11, and 42 [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Prevailing of HPV-16 and 52 genotype in 2022–2023 in Sanandaj, Iran

Haddadi,

Atefmehr,

Motlaghzadeh

et al. 2024

Virol J

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Introduction Human papillomavirus (HPV) presents a potential threat to the onset of carcinogenesis in the cervix, anogenital regions, and oropharynx. HPV encompasses over 200 types, with at least 12 having the potential to cause cancer, impacting the majority of sexually active individuals. In this current research, we explore the occurrence and spread of HPV genotypes. Material and methods During this cross-sectional study conducted in Sanandaj, Iran from Feb 2022 to Aug 2023, diverse samples including oral, vaginal, and genital were collected from individuals referred to private laboratories in Sanandaj, Iran. After sample collection and DNA extraction (FAVORGEN, Taiwan), they were subjected to PCR and genotyping (MehrViru, Iran). The subsequent statistical analysis unveiled infection rates across different demographics and age groups. STATA (version 17) were used for statistical analysis. We examined infection rates across demographics using t-tests and Odds Ratio. Results Overall, 26% (249) out of 950 cases tested positive for HPV, with 69% of these classified as high-risk. Among the examined population, 98% (933) were female, and 2% (17) were male. Females aged 31–40 exhibited the highest percentage of HPV prevalence (115/460) in the study with the majority of positive cases belonging to HR genotypes. The overall most frequent genotypes identified were 6, 16, 52, 53, 51, 58, and 56. HPV-16 exhibited the highest frequency among HR genotypes, accounting for 42 (17%) occurrences, followed by HPV-52 with a frequency of 32 (13%). Conclusion Our findings emphasize the significant prevalence of HPV among females, particularly in the 21–30 age group. The identification of high-risk genotypes, underscores the importance of targeted interventions for specific age cohorts. The age-stratified analysis highlights a consistent predominance of high-risk HPV across age groups, indicating the need for age-specific preventive measures. These results contribute valuable information for designing effective screening and vaccination strategies, to alleviate the impact of diseases associated with HPV.

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“…Each year, almost 200 000 deaths caused by cervical cancer occur; this rate is higher than 12 000 new cases of cervical cancer in developed countries annually. Of this rate, 4 000 deaths are associated with this disease (2). The majority of studies have demonstrated that several high-risk types of HPV affect the development of cervix cancer as they have been recognized in about 99% of cervix cancers in the world (19).…”

Section: Discussionmentioning

confidence: 99%

“…It is mainly transmitted through sexual intercourse. The importance of this virus is its role in increasing the risk of cervical cancer (1), the fourth leading cancer in women, which constitutes about 7% of mortalities due to cancer among women in 2018 (2). About 370 women died due to cervical cancer in our country in 2012, which is, according to predictions, an increase in all ages by 2035 (3).…”

Section: Introductionmentioning

confidence: 99%

The Prevalence of Human Papillomavirus Genotypes in Women with Genital Warts Using Polymerase Chain Reaction (PCR)

2023

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Background: The genotypic distribution of human papillomavirus (HPV) needs to be determined with detail as it is an important issue when it comes to public health and preparing vaccines since the HPV type may be different in various areas. Objectives: This study aimed at reporting the frequency of HPV types among women in Sari in the north of Iran. Methods: From 2018 October to 2019 April, 50 sterile swabs of vaginal and cervical discharge of women with genital warts, which were performed by a gynecologist, were examined to determine the prevalence of HPV genotyping by using polymerase chain reaction (PCR). Results: From 50 vaginal swab samples of patients with genital warts, the frequency distribution of types of HPV in women with genital warts included 5 patients (10.0%) with 2 high-risk serotypes as simultaneous serotypes 4% (16, 18), 4% (18, 35), 2% (66, 67), 1 patient (2%) HPV 33, 1 patient (2%) HPV 34, 1 patient (2%) 1 patient (2%) HPV 35, 2 patients (4%) HPV 66, 1 patient (2%) HPV 67, and 1 patient (2%) HPV 68. Conclusions: Since HPV genotype varies in diverse areas, these results can be used for screening, management, and vaccination of the target population against the common types of virus in Sari.

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Genotype distribution of human papilloma virus among women with genital warts biopsies in southern Khorasan, eastern Iran

Cited by 3 publications

References 28 publications

Investigation of frequency and typing of human papillomavirus among genital warts using a reverse dot blot hybridization approach

Investigation of frequency and typing of human papillomavirus among genital warts using a reverse dot blot hybridization approach

Prevailing of HPV-16 and 52 genotype in 2022–2023 in Sanandaj, Iran

The Prevalence of Human Papillomavirus Genotypes in Women with Genital Warts Using Polymerase Chain Reaction (PCR)

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