Genotype Distribution of the Single Nucleotide Polymorphism Val158Met of the COMT Gene in the Syrian Population

Lajin, Bassam; Sakur, Amir Alhaj; Hamzeh, Abdul Rezzak; Alachkar, Amal

doi:10.3923/jbs.2010.701.704

Cited by 4 publications

(3 citation statements)

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“…[14][15][16][17][18]. Hence, these findings raised the possibility that the Val158Met polymorphisms of COMT gene might be necessary in the development of certain ADHD symptoms [19][20][21][22][23]. Our study found a significant association between G/A variations of COMT gene and clinical phenotypes of ADHD children.…”

Section: Discussionsupporting

confidence: 59%

Pathogenic study on catechol-O-methyltransferase gene and catecholaminergic neurotransmitters with attention deficit hyperactivity disorder in Chinese children

Xiong¹,

Yan²,

Shi

2020

Preprint

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Background: This study analyzed a correlation between the Val158Met polymorphisms of catechol-O-methyltransferase (COMT) gene and catecholaminergic neurotransmitters in ADHD children. Methods: All subjects were genotyped for the Val158Met polymorphisms of COMT gene and determined in the difference of dopamine and noradrenalin by a 1:1 paired case-control study. Results: The frequencies of A/A, G/A and G/G were 51.67%, 41.11% and 7.22% in the case group, 62.22%, 31.11% and 6.67% in the control group. There was a significant difference in the distribution of all genotypes of COMT gene between the two groups (OR=1.85, χ2=7.80, P<0.05). The serum concentrations of dopamine and noradrenalin were 1.42±0.34 ng/ml and 177.70±37.92 pg/ml in the case group, 1.94±0.42 ng/ml and 206.20±42.45 pg/ml in the control group. There were the significant differences in the levels of dopamine and noradrenalin between the two groups (dopamine: t=4.30, P<0.01. noradrenalin: t=2.24, P<0.05). Conclusions: Our study suggested that there was the positive association between the Val158Met polymorphisms of COMT gene and catecholaminergic neurotransmitters in ADHD children.

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Section: Discussionsupporting

confidence: 59%

Pathogenic study on catechol-O-methyltransferase gene and catecholaminergic neurotransmitters with attention deficit hyperactivity disorder in Chinese children

Xiong¹,

Yan²,

Shi

2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Our study found that A/A frequency of genotypes was lower in the case group than that in the control group, and there was the association between the Val158Met polymorphisms of the COMT gene in ADHD children and adolescents. Hence, these findings raised the possibility that the Val158Met polymorphisms of the COMT gene might be necessary in the development of certain ADHD symptoms [22–25] …”

Section: Discussionmentioning

confidence: 99%

“…Hence, these findings raised the possibility that the Val158Met polymorphisms of the COMT gene might be necessary in the development of certain ADHD symptoms. [22][23][24][25] However, several studies have also found no correlation between the Val158Met polymorphisms of the COMT gene in ADHD children and adolescents. [26][27] The conclusions of these studies might be influenced by the following factors: First, several studies were obtained from a small number of selected subjects which were not reasonable to consider these results of the correlation studies.…”

Section: Frequency Of Genotypes (%)mentioning

confidence: 99%

Val158Met polymorphisms of COMT gene and serum concentrations of catecholaminergic neurotransmitters of ADHD in Chinese children and adolescents

Xiong¹,

Yan²,

Shi

2021

Medicine

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This study analyzed the Val158Met polymorphisms of the catechol-O-methyltransferase (COMT) gene and serum concentrations of catecholaminergic neurotransmitters in attention deficit hyperactivity disorder (ADHD) children and adolescents. All the subjects (180 paired ADHD and non-ADHD children and adolescents) were genotyped for the Val158Met polymorphisms of the COMT gene, and determined by the difference of dopamine and noradrenalin from a 1:1 paired case–control study. The frequencies of methionine (A)/A, valine (G)/A, and G/G were 51.67%, 41.11%, and 7.22% in the case group, and 62.22%, 31.11%, and 6.67% in the control group. There was a significant difference in the distribution of all genotypes of the COMT gene between the 2 groups (odds ratio = 1.85, 95% confidence interval: 1.62–2.08; χ 2 = 7.80, P < .05). The serum concentrations of dopamine and noradrenalin were 1.42 ± 0.34 ng/mL and 177.70 ± 37.92 pg/mL in the case group, and 1.94 ± 0.42 ng/mL and 206.20 ± 42.45 pg/mL in the control group. There were the significant differences in the levels of dopamine and noradrenalin between the 2 groups (dopamine: t = 4.30, P < .01; noradrenalin: t = 2.24, P < .05). Our study suggested that the Val158Met polymorphisms of the COMT gene and serum concentrations of catecholaminergic neurotransmitters were associated with ADHD children and adolescents.

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Catechol-O-methyltransferase Val 108/158 Met polymorphism and breast cancer risk: a case control study in Syria

et al. 2011

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Genotype Distribution of the Single Nucleotide Polymorphism Val158Met of the COMT Gene in the Syrian Population

Cited by 4 publications

References 4 publications

Pathogenic study on catechol-O-methyltransferase gene and catecholaminergic neurotransmitters with attention deficit hyperactivity disorder in Chinese children

Pathogenic study on catechol-O-methyltransferase gene and catecholaminergic neurotransmitters with attention deficit hyperactivity disorder in Chinese children

Val158Met polymorphisms of COMT gene and serum concentrations of catecholaminergic neurotransmitters of ADHD in Chinese children and adolescents

Catechol-O-methyltransferase Val 108/158 Met polymorphism and breast cancer risk: a case control study in Syria

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