Genotype of stearoyl-CoA desaturase is associated with fatty acid composition in Japanese Black cattle

Taniguchi, Masaaki; Utsugi, Takeshi; Oyama, Kenji; Mannen, Hideyuki; Kobayashi, Masato; Tanabe, Yasutaka; Ogino, Akifumi; Tsuji, Soichi

doi:10.1007/s00335-003-2286-8

Cited by 269 publications

(261 citation statements)

References 23 publications

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“…Similar to previous reports (Asadollahpour Nanaei et al, 2013), the frequencies for the A and V alleles of the SCD1-A293V polymorphism in the current study were 0.58 and 0.42, respectively. Consistent with results from the present study, a higher frequency of the A allele in comparison with the V allele has been reported in Japanese Black cattle (Taniguchi et al, 2004), Italian Holstein (Mele et al, 2007), Valdostana breed (Moioli et al, 2007) and Canadian Jersey (Kgwatalala et al, 2009). On the contrary, in the Piedmontese breed (Moioli et al, 2007) and Italian Brown cattle (Conte et al, 2010) the V allele had a higher frequency compared with the A allele.…”

Section: Resultssupporting

confidence: 92%

Effect of polymorphisms in the ABCG2, LEPR and SCD1 genes on milk production traits in Holstein cows

et al. 2016

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This study was performed to investigate the association between polymorphisms in the ABCG2 (ATPbinding cassette sub-family G member 2), LEPR (leptin receptor) and SCD1 (stearoyl-coenzyme A desaturase 1) genes and milk production traits in Holstein dairy cows in Iran. The analysis was conducted on 816 lactations from 408 Iranian Holstein cows. Genotyping was carried out using the PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) technique. The results of the association study revealed that cows with genotype AC of the ABCG2-Y581S single nucleotide polymorphism (SNP) had lower breeding value for milk yield compared with the AA genotype, but showed significantly higher fat and protein percentages. Cows that were homozygous for allele T at the LEPR-T945M locus had higher breeding value for fat yield than those that were homozygous for the C allele. Regarding the SCD1-A293V SNP, cows with genotype AV produced a higher 305-day milk yield in comparison with cows with the VV genotype. Furthermore, cows that were homozygous for allele V showed a significantly higher protein percentage compared with AA and AV genotypes. The results of this study suggest that these SNPs have the potential to be used in programmes based on genomic selection in Iranian dairy herds. ______________________________________________________________________________________

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Section: Resultssupporting

confidence: 92%

Effect of polymorphisms in the ABCG2, LEPR and SCD1 genes on milk production traits in Holstein cows

et al. 2016

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“…The SCD gene is associated with fatty acid composition and converts stearic acid into oleic acid. Recently, Taniguch et al (7) reported that a non-synonymous SNP in Exon IV of the SCD gene lead to a change in the monounsaturated fatty acid composition in Japanese black cattle. In addition, the SCD enzyme activity was positively correlated with unsaturated fatty acid composition (8).…”

Section: Resultsmentioning

confidence: 99%

Identification of marbling-related candidate genes in M. longissimus dorsi of high- and low marbled Hanwoo (Korean Native Cattle) steers

Lee¹,

Cho²,

Lee³

et al. 2008

BMB Reports

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This study was conducted to identify marbling-related candidate genes in M. longissimus dorsi of high-and low-marbled Hanwoo. The longissimus dorsi muscles were selected for gene expression from eight Hanwoo steer carcasses based on crude fat content. In the analysis of variance, gene expression of five candidate genes, FABP4, SCD, PPARγ, Titin and Nebulin was determined to be significantly different between high-and low-marbled Hanwoo steers (P ＜ 0.0001). The Pik-4 and CaMK II genes were also shown to have a significant effect on crude fat content (P ＜ 0.01). In the analysis of the differential expression between high-and low marbled groups, FABP4 gene expression was approximately 2 times higher in the high marbled group relative to the low marbled group. However, the PPARγ and SCD gene were highly expressed in the low marbled group. In addition, Titin and Nebulin were highly expressed in the low marbled group when placed under relatively high shear force. Finally, the Pik-4 and CaM K II gene also displayed a high expression pattern in the low marbled group. [BMB reports 2008; 41(12): 846-851]

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“…RA may also originate from endogenous synthesis by way of the stearoyl Co-A desaturase (SCD) enzyme, which is able to insert a double bound in the cis-9 position in a large spectrum of fatty acids, including VA. The level of the SCD expression was tested in lactating and growing cattle (Delbecchi et al, 2001and Taniguchi et al, 2004, but little is known about the SCD activity in pre-weaning lambs. SCD activity may be determined by tissue sampling, but this method is very expensive and invasive.…”

Section: Discussionmentioning

confidence: 99%

Conjugated Linoleic Acid (CLA) content of meat from three muscles of Massese suckling lambs slaughtered at different weights

et al. 2009

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Eighteen Massese male lambs, fed mainly maternal milk were slaughtered at 11, 14 and 17 kg. Samples of Longissimus Dorsi (LD), Triceps Brachii (TB) and Semimembranosus (Sm) muscles were collected. Milk from the lamb's dams was sampled weekly. Fatty acid composition of milk and meat was determined.TB was the fattest muscle, Sm the leanest one and LD showed an intermediate value of total lipids, while the weight at slaughter did not influence total intramuscular fat content in any muscle. Although slaughter weight slightly affected overall fatty acid composition of muscles, rumenic acid and total CLA content in TB and Sm, but not in LD, significantly increased with slaughter weight. As regard milk fatty acid composition, the contents of total CLA, RA and others minor CLA isomers decreased during the first four weeks after lambing and then increased at the last control (five weeks). The animals slaughtered at a live weight of 14 and 17 kg showed a greater SCD enzyme activity (estimated by product/substrate ratio) and a higher rumen activity (estimated by means of branched chain and odd chain fatty acid content in meat) than animals slaughtered at 11 kg. CLA content significantly increased with the slaughter age in TB and SM, while trans-7, trans-9 CLA, only increased in TB, and cis-8, cis-10 CLA, only increased in SM. Further studies are needed in order to verify weather the different behaviour of RA in LD muscle may be due to differences in muscle metabolism or fatty acid utilisation.

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Genotype of stearoyl-CoA desaturase is associated with fatty acid composition in Japanese Black cattle

Cited by 269 publications

References 23 publications

Effect of polymorphisms in the ABCG2, LEPR and SCD1 genes on milk production traits in Holstein cows

Effect of polymorphisms in the ABCG2, LEPR and SCD1 genes on milk production traits in Holstein cows

Identification of marbling-related candidate genes in M. longissimus dorsi of high- and low marbled Hanwoo (Korean Native Cattle) steers

Conjugated Linoleic Acid (CLA) content of meat from three muscles of Massese suckling lambs slaughtered at different weights

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