2019
DOI: 10.1080/09674845.2019.1637573
|View full text |Cite
|
Sign up to set email alerts
|

Genotypic analysis of XRCC4 and susceptibility to cervical cancer

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

0
7
0

Year Published

2020
2020
2024
2024

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 13 publications
(7 citation statements)
references
References 23 publications
0
7
0
Order By: Relevance
“…With the application and development of high‐throughput sequencing, gene chip in research of tumor genomics, it is significant to find the mechanism, prognostic factors, and potential therapeutic targets of cervical cancer. Some studies have reported that mutations of FOXP3 (Cezar‐Dos‐Santos et al, 2019), PIK3CA (Razia et al, 2019), XRCC4 (Gupta, Kushwah, Singh, & Banerjee, 2019), FBXW7 (Liu et al, 2019), and some copy number variations of KLF10 and PSG (Marrero‐Rodriguez et al, 2018) are related to the carcinogenesis and pathogenesis of cervical cancer, but they were not complete so that to be further studied. This study aim to better understand the characteristics of some genes and signaling pathways that associate with cervical cancer through bioinformatics.…”
Section: Introductionmentioning
confidence: 99%
“…With the application and development of high‐throughput sequencing, gene chip in research of tumor genomics, it is significant to find the mechanism, prognostic factors, and potential therapeutic targets of cervical cancer. Some studies have reported that mutations of FOXP3 (Cezar‐Dos‐Santos et al, 2019), PIK3CA (Razia et al, 2019), XRCC4 (Gupta, Kushwah, Singh, & Banerjee, 2019), FBXW7 (Liu et al, 2019), and some copy number variations of KLF10 and PSG (Marrero‐Rodriguez et al, 2018) are related to the carcinogenesis and pathogenesis of cervical cancer, but they were not complete so that to be further studied. This study aim to better understand the characteristics of some genes and signaling pathways that associate with cervical cancer through bioinformatics.…”
Section: Introductionmentioning
confidence: 99%
“…The implications of these later variants remain to be clarified. However, both are associated with increased risk for several cancer types, including acute childhood leukemia (Wu et al, 2010;Shao et al, 2013;Jin et al, 2019;Gupta et al, 2020).…”
Section: Introductionmentioning
confidence: 99%
“…Other affected pathways are the repair of oxidative damage to guanine (8-oxoguanine) by the OGG1 (8-Oxoguanine DNA Glycosylase) gene [4,10,15]; and the non-homologous end-joint mechanism (NHEJ) that is responsible for the repair of double-stranded DNA breaks, by XRCC4 (X-Ray Repair Cross-Complementing Group 4) repair gene. The basic mechanism involved in each repair pathway is shown in Figure 1 [16][17][18].…”
Section: State Of Knowledgementioning
confidence: 99%
“…The XRCC4 gene is located on chromosome 5 at 5q14.2. It encodes a phosphoprotein called X-Ray Repair Cross-complementing Group 4 that contains 336 amino acids and three constituent domains [17,27,28]. This protein plays a major role in the NHEJ mechanism, which is necessary for the repair of double-stranded DNA breaks [16,29,30].…”
Section: State Of Knowledgementioning
confidence: 99%