Genotypic and phenotypic drug resistance of M.tuberculosis in patients registered in Moscow, Russia

Krasnova, M. A.; Belilovskiy, Evgeny; Khakhalina, Anastasia; Borisov, Sergey; Safonova, S G; Nosova, Elena

doi:10.1183/13993003.congress-2018.pa3676

Cited by 1 publication

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“…It seems reasonable to evaluate the similarities and differences in the clinical and radiographic manifestations of pTB and NTMPD in combination when comparing isolated extensively drug-resistant fibro-cavitary TB and isolated NTMPD [ 4 , 7 , 8 , 9 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ]. This may allow the physician to identify situations where additional examinations are required to detect not only MBT but also NTM, since the finding of NTM in sputum, bronchoalveolar lavage, biopsies and operative material forms the basis for a reliable verification of NTMPD.…”

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confidence: 99%

A Comparison of Clinical and Radiographic Signs of Nontuberculous Mycobacterial Pulmonary Disease, Destructive Drug-Resistant Pulmonary Tuberculosis and a Combination of Nontuberculous Mycobacterium Pulmonary Disease and Pulmonary Tuberculosis

Giller,

Scherbakova,

Enilenis

et al. 2023

Pathogens

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A misdiagnosis of isolated pulmonary tuberculosis (pTB) is highly likely when a patient has nontuberculous mycobacterial pulmonary disease (NTMPD) or a combination of nontuberculous mycobacterium pulmonary disease and pulmonary tuberculosis. Frequently, bacterial excretion is absent or only Mycobacteria tuberculosis (MBT) is found. This often results in an incorrect diagnosis and subsequent misinformed treatment regimes. In order to determine possible clinical and radiographic differences between patients with NTMPD (Group 1), destructive drug-resistant pulmonary tuberculosis (Group 3) and a combination of NTMPD and pTB (Group 2) we compare clinical and radiographic signs for these three patient groups. When comparing with Group 3 (2.5%), Groups 1 (25%) and 2 (17.4%) have a substantially higher incidence of pulmonary haemorrhages. Thus, upon clinically observing the combination of pTB and NTMPD, there are no pathognomonic clinical and radiographic detected symptoms. However, the presence of an indolent course, hemoptysis and bronchiectasis in the presence of acid-fast bacteria (or identified MBT) in the sputum makes it possible to suspect not simple pTB, but a combination of pTB and NTMPD. To clarify this necessitated in-depth bacteriological examination.

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