Genotypically distinct Leishmania colombiensis isolates from Venezuela cause both cutaneous and visceral leishmaniasis in humans

Rodríguez-Bonfante, Claudina; Bonfante-Garrido, Rafael; Grimaldi, Gabriel; Momen, Hooman; Cupolillo, Elisa

doi:10.1016/s1567-1348(03)00012-1

Cited by 33 publications

(22 citation statements)

References 17 publications

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“…22 L. colombiensis, the species with which our new species is closely clustered, contributes to both American tegumentary leishmaniasis (ATL) and American VL (AVL). 23 The single ulcerative skin lesion in our patient 1 is common in new world CL, whereas the multiple papules and nodules with a few shallow ulcers in our patient 2 were similar to the manifestations found in both old world and new world CL. 24 However, in Thailand, the differential diagnosis of such ulcerative lesions includes histoplasmosis and penicillosis, which are the more common opportunistic infections in HIVinfected patients.…”

Section: Discussionmentioning

confidence: 99%

Consecutive Cutaneous and Visceral Leishmaniasis Manifestations Involving a Novel Leishmania Species in Two HIV Patients in Thailand

Chusri¹,

Hortiwakul²,

Silpapojakul³

et al. 2012

The American Society of Tropical Medicine and Hygiene

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Abstract. Leishmaniasis is an emerging disease in Thailand. Herein, we report on two human immunodeficiency virus (HIV)-infected patients with leishmaniasis who presented with overlapping manifestations between cutaneous and visceral leishmaniasis. Sequencing analysis of the internal transcribed spacer 1 (ITS1) of the ribosomal RNA gene showed that the species was identical to a new species recently described in Thailand. The detection of DNA of this Leishmania species in saliva may have important implications for transmission and epidemiological studies.

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Section: Discussionmentioning

confidence: 99%

Consecutive Cutaneous and Visceral Leishmaniasis Manifestations Involving a Novel Leishmania Species in Two HIV Patients in Thailand

Chusri¹,

Hortiwakul²,

Silpapojakul³

et al. 2012

The American Society of Tropical Medicine and Hygiene

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“…Because of the high level of polymorphism in the composition of the ITS locus, several molecular epidemiological studies have been conducted by RFLP analysis in New World taxa (5,10,21,38), but most studies have been performed on Old World Leishmania species (7,19,34,(44)(45)(46)(47). Analyses of the ribosomal ITS regions of different parasites have demonstrated the utility of this marker in detecting genetic diversity and any association of this diversity with several epidemiological aspects (16,33).…”

Section: Discussionmentioning

confidence: 99%

Molecular Epidemiology of Leishmania ( Viannia ) guyanensis in French Guiana

et al. 2006

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Little information is available about the genetic variability of Leishmania populations and the possible correlations with ecoepidemiological features of leishmaniases. The present study was carried out in French Guiana, a country where cutaneous leishmaniases (CL) are endemic over the whole territory. The genetic polymorphism of a nuclear sequence encompassing the end of the ribosomal small subunit and the internal transcribed spacer 1 of 265 isolates from patients with CL was examined by restriction fragment length polymorphism analysis. Genotypes based on the fingerprinting phenetic integration were compared to epidemiological, clinical, and geographical data. In agreement with previous reports, five different Leishmania species were identified, but Leishmania (Viannia) guyanensis represented 95.8% of the samples. Two distinct L. (V.) guyanensis populations were found to originate in two ecologically characterized regions. Higher lesional parasite densities and the need for additional treatments were significantly linked to genotype group I. Parasites of genotype group II were more likely to cause chronic and disseminated cutaneous forms in patients. L. (V.) guyanensis was previously said not to be very polymorphic; however, the present analysis resulted in a significant degree of discrimination among L. (V.) guyanensis isolates from diverse ecological areas and with different clinical implications.In the highly biodiversified region of the New World (NW) that encompasses the northern Amazon Basin and the Guiana Shield, at least seven named species belonging to the Leishmania genus coexist with often overlapping hosts and vectors (39). American visceral leishmaniases due to Leishmania (Leishmania) infantum are found there, but cases of cutaneous leishmaniases (CL) are far more numerous. Human cutaneous infections may be unapparent; however, many of the Leishmania parasites are able to produce a spectrum of diseases rather than a single clinical form. Cases reported in that region range from localized and diffuse cutaneous forms to mucocutaneous leishmaniases. They are now being reported in areas where leishmaniases had previously not been endemic (2, 17): increasing risk factors related to natural and especially manmade environmental changes are making leishmaniases a growing public health concern in this particular region. However, little information is available about the genetic variability of parasite populations and the possible correlation with ecoepidemiological features of the diseases. The present study was carried out in French Guiana, a country where CL are endemic over the whole territory (incidence of 0. 2% between 1979 and 2000 [6, 14]). The genetic polymorphism of a nuclear sequence encompassing the end of the ribosomal small subunit (SSU) and the internal transcribed spacer 1 (ITS1) of 265 samples from patients with CL was examined by restriction fragment length polymorphism (RFLP) analysis. Genotypes based on the fingerprinting phenetic integration were then compared to epidemiological, clin...

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“…22,[26][27][28][29] Leishmania (V.) colombiensis was also shown to cause both cutaneous and visceral forms of the disease, and at least two distinct etiologic agents are present in Venezuela but not strictly in the GEC. 30 Cutaneous leishmaniases. Localized cutaneous leishmaniasis.…”

Section: American Visceral Leishmaniasis American Visceral Leishmanimentioning

confidence: 99%

Ecology of the Leishmania Species in the Guianan Ecoregion Complex

Rotureau

2006

The American Journal of Tropical Medicine and Hygiene

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Abstract. In the Guianan ecoregion complex, at least seven Leishmania species belonging to both the L. (Leishmania) Saf' janova, 1982 and L. (Viannia) Lainson and Shaw, 1987 sub-genera are causative agents of American visceral leishmaniasis, mucocutaneous leishmaniasis, and cutaneous leishmaniases, including localized and diffuse forms. They are mostly sylvatic species subjugated to their own specific Lutzomyia sand fly vectors and to particular wild mammalian reservoir hosts of the dense rain forest. Originally implicated strictly in wild zoonoses and developing in forested ecotopes, Leishmania show a particular adaptive plasticity to face environmental modifications following deforestation and anthropization. This review presents the different pathogenic complexes of these parasites, emphasizes their implication in human diseases, and considers the influence of humans on their ecology.

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Genotypically distinct Leishmania colombiensis isolates from Venezuela cause both cutaneous and visceral leishmaniasis in humans

Cited by 33 publications

References 17 publications

Consecutive Cutaneous and Visceral Leishmaniasis Manifestations Involving a Novel Leishmania Species in Two HIV Patients in Thailand

Consecutive Cutaneous and Visceral Leishmaniasis Manifestations Involving a Novel Leishmania Species in Two HIV Patients in Thailand

Molecular Epidemiology of Leishmania ( Viannia ) guyanensis in French Guiana

Ecology of the Leishmania Species in the Guianan Ecoregion Complex

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