Genotyping of Coxiella burnetii detected in placental tissues from aborted dairy cattle in the north of Algeria

Rahal, Mohamed; Tahir, Djamel; Eldin, Carole; Bitam, Idir; Raoult, Didier; Parola, Philippe

doi:10.1016/j.cimid.2018.06.001

Cited by 18 publications

(11 citation statements)

References 22 publications

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“…Compared to that study, our research has found a higher rate of placental infection with C. burnetii in the retained fetal membranes (88.9%) and a similar infection rate in normally separated placentas (40.3%). Rahal et al (2018) , which shows a similar percentage to that of samples from aborted cows. Some studies also found that the placentas of many parturient cows were infected by C. burnetii (Luoto et al, 1952), and 7.3% C. burnetii positivity was found by PCR in bovine cotyledons in the United Kingdom (Pritchard et al, 2011).…”

supporting

confidence: 67%

“…Recent studies have demonstrated that C. burnetii infection is highly prevalent on dairy cattle farms of the Central and Eastern European countries both at farm (93.78%) (Dobos et al, 2020b) and individual animal level (52%) (Dobos et al, 2020a). The high prevalence of C. burnetii on dairy farms may be a risk factor for human infection and it is also related to C. burnetii-associated reproductive disorders such as abortion, premature delivery, stillbirth, and weak offspring complex (APSW complex), early pregnancy loss and the retention of fetal membranes (Agerholm, 2013;Rahal et al, 2018;Dobos et al, 2020a). A similar large-scale study found a 52.9% rate of C. burnetii positive cases among 170 cotyledons from dairy cattle by real-time PCR targeting the IS1111a and icd genes in Denmark (Hansen et al, 2011).…”

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confidence: 99%

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Prevalence of Coxiella burnetii in bovine placentas in Hungary and Slovakia: Detection of a novel sequence type – Short communication

2021

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Cotyledons (n = 167) from 30 Hungarian and 5 Slovakian dairy cattle herds were analysed for Coxiella burnetii by real-time PCR targeting the IS1111 gene. Eighty (88.9%) out of the 90 cotyledons from retained placentas and 31 (40.3%) out of the 77 cotyledons from normally separated placentas tested positive. Seventeen out of the 80 positive samples (21.3%) originating from retained placentas were found to be highly loaded with C. burnetii with a cycle threshold (Ct) value lower than or equal to 27.08, ranging between 11.92 and 27.08. The rest of the positive samples from retained fetal membranes and from normally separated placentas were moderately loaded with C. burnetii DNA. Five out of the ten samples showing the strongest positivity (Ct 11.92–18.28) from retained placentas were genotyped by multispacer sequence typing based on ten loci, which revealed sequence type (ST) 61, a type that had not been detected in Hungary and Slovakia previously. Retained placenta was more likely in cows with C. burnetii PCR-positive cotyledons (odds ratio: 12.61, P = 0.0023). The high C. burnetii DNA load found in retained fetal membranes may be a potential risk factor for human infection and may also be associated with the retention of fetal membranes.

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confidence: 67%

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confidence: 99%

Prevalence of Coxiella burnetii in bovine placentas in Hungary and Slovakia: Detection of a novel sequence type – Short communication

2021

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“…The different clinical manifestations of the disease can lead to late gestation abortions, fertility disorders, and premature delivery (192,193). Up to 10 9 bacteria per gram can be contained in the placenta from infected ruminants (194)(195)(196). C. burnetii shedding is higher in vaginal mucus and feces than milk in the first 3 weeks postabortion or postpartum (197).…”

Section: The Main Known Reservoirs Of Coxiella Burnetii: Cattle Sheementioning

confidence: 99%

Coxiella burnetii in Dromedary Camels (Camelus dromedarius): A Possible Threat for Humans and Livestock in North Africa and the Near and Middle East?

et al. 2020

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The "One Health" concept recognizes that human health is connected to animal health and to the ecosystems. Coxiella burnetii-induced human Q fever is one of the most widespread neglected zoonosis. The main animal reservoirs responsible for C. burnetii transmission to humans are domesticated ruminants, primarily goats, sheep, and cattle. Although studies are still too sparse to draw definitive conclusions, the most recent C. burnetii serosurvey studies conducted in herds and farms in Africa, North Africa, Arabian Peninsula, and Asia highlighted that seroprevalence was strikingly higher in dromedary camels (Camelus dromedarius) than in other ruminants. The C. burnetii seroprevalence in camel herds can reach more than 60% in Egypt, Saudi Arabia, and Sudan, and 70 to 80% in Algeria and Chad, respectively. The highest seroprevalence was in female camels with a previous history of abortion. Moreover, C. burnetii infection was reported in ticks of the Hyalomma dromedarii and Hyalomma impeltatum species collected on camels. Even if dromedary camels represent <3% of the domesticated ruminants in the countries of the Mediterranean basin Southern coast, these animals play a major socioeconomic role for millions of people who live in the arid zones of Africa, Middle East, and Asia. In Chad and Somalia, camels account for about 7 and 21% of domesticated ruminants, respectively. To meet the growing consumers demand of camel meat and milk (>5 million tons/year of both raw and pasteurized milk according to the Food and Agriculture Organization) sustained by a rapid increase of population (growth rate: 2.26-3.76 per year in North Africa), dromedary camel breeding tends to increase from the Maghreb to the Arabic countries. Because of possible long-term persistence of C. burnetii in camel hump adipocytes, this pathogen could represent a threat for herds and breeding farms and ultimately for public health. Because this review highlights a hyperendemia of C. burnetii in dromedary camels, a proper screening of herds and breeding farms for C. burnetii is urgently needed in countries where camel breeding is on the rise. Moreover, the risk of C. burnetii transmission from camel to human should be further evaluated.

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“…To date there has been limited genotyping of C. burnetii samples across Africa, and studies utilizing genotyping have been skewed towards MST analysis of individual human infections and tick populations (see Figure 1). While livestock infections are largely underrepresented in molecular analysis, the presence of MST20 in Algerian cattle abortions is an important observation (Rahal et al, 2018).…”

Section: Future Directionsmentioning

confidence: 99%

Current perspectives on the transmission of Q fever: Highlighting the need for a systematic molecular approach for a neglected disease in Africa

et al. 2019

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Genotyping of Coxiella burnetii detected in placental tissues from aborted dairy cattle in the north of Algeria

Cited by 18 publications

References 22 publications

Prevalence of Coxiella burnetii in bovine placentas in Hungary and Slovakia: Detection of a novel sequence type – Short communication

Prevalence of Coxiella burnetii in bovine placentas in Hungary and Slovakia: Detection of a novel sequence type – Short communication

Coxiella burnetii in Dromedary Camels (Camelus dromedarius): A Possible Threat for Humans and Livestock in North Africa and the Near and Middle East?

Current perspectives on the transmission of Q fever: Highlighting the need for a systematic molecular approach for a neglected disease in Africa

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