Gentiopicroside ameliorates ovalbumin-induced airway inflammation in a mouse model of allergic asthma via regulating SIRT1/NF-κB signaling pathway

Zou, Bo; Fu, Yue; Cao, Chaofan; Pan, Dianzhu; Wang, Wei; Kong, Lingfei

doi:10.1016/j.pupt.2021.102034

Cited by 21 publications

(16 citation statements)

References 41 publications

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“…Chen et al demonstrated that resveratrol played a role by upregulating the expression of phosphatase and tensin homolog (PTEN) via activating SIRT1 [ 42 ]. Both gentiopicroside and pterostilbene have anti-inflammatory roles in asthma via upregulating the expression of SIRT1 [ 43 , 44 ]. Additionally, myricetin increases the deacetylase activity of SIRT1, thus inhibiting tumor necrosis factor α (TNF-α)-induced nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) activation and reducing the inflammatory response [ 45 ].…”

Section: Roles Of Sirtuins In Asthmamentioning

confidence: 99%

Roles of sirtuins in asthma

Liu

Shi

2022

Respir Res

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Sirtuins are nicotinamide adenine dinucleotide (NAD+)-dependent lysine deacylases and deacetylases that participate in a variety of cellular processes, including transcriptional activity, energy metabolism, DNA damage response, inflammation, apoptosis, autophagy, and oxidative stress. As a result, sirtuins are linked to multiple pathophysiological processes, such as cardiovascular diseases, metabolic diseases, autoimmune diseases, infectious diseases, and respiratory diseases. Asthma is the most common respiratory disease, which is characterized by airway inflammation and airway remodeling. Accumulating evidence has indicated that sirtuins are involved in the pathogenesis of asthma. Furthermore, some studies have suggested that sirtuin modulators are potential agents for the treatment of asthma via alteration of the expression or activity of sirtuins. In this review, we illustrate the role of sirtuins in asthma, discuss related molecular mechanisms, and evaluate the sirtuins-targeted therapy for asthma.

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Section: Roles Of Sirtuins In Asthmamentioning

confidence: 99%

Roles of sirtuins in asthma

Liu

Shi

2022

Respir Res

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“…Among them, three compounds were all inconformity with the filtering criteria of F30%, including kaempferide, quercetin and genipicroside. Given that their evident anti-inflammatory function have been reported in previous studies ( Chen et al, 2018 ; Ren et al, 2019 ; Manzoor et al, 2021 ; Zou et al, 2021 ), we eventually included them in our study. Eventually, there were 51 components in Scutellaria baicalensis, 31 components in Radix stemonae, 20 components in Radix peucedani, 11 components in Hedyotis diffusa, 3 components in Gentiana rhodantha, 2 components in Firminna simplex root, and 2 components in Threevein aster.…”

Section: Resultsmentioning

confidence: 99%

“…FLKM has comprehensive effectiveness in the treatment of pneumonia, including antitussive, expectorant and improving respiratory function, which mainly depends on the characteristics of multicomponent. For instance, resveratrol ( Ding et al, 2019 ; Liu et al, 2020 ), quercetin ( Manzoor et al, 2021 ), kaempferol ( Ren et al, 2019 ), and geniopicroside ( Chen et al, 2018 ; Zou et al, 2021 ) can inhibit the secretion of inflammatory mediators and attenuate inflammatory reactions by acting on multiple targets. Nevertheless, the mechanisms of FLKM in treating pneumonia have not been elucidated.…”

Section: Introductionmentioning

confidence: 99%

The TCM Preparation Feilike Mixture for the Treatment of Pneumonia: Network Analysis, Pharmacological Assessment and Silico Simulation

et al. 2022

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The Feilike mixture (FLKM) is a valid prescription that is frequently used to assist in the clinical treatment of pneumonia. However, the mechanisms of its effects remain unclear. First, through literature evaluation, it was preliminarily determined that FLKM improved clinical symptoms, regulated immune inflammation response and ameliorated pulmonary function. Then, via database search and literature mining, 759 targets of the 104 active compounds of FLKM were identified. The component-target (CT) network showed that the key active compositions were resveratrol, stigmasterol, beta-sitosterol, sesamin, and quercetin. 115 targets overlapped with pneumonia-related targets. The protein-protein interaction (PPI) network identified TNF, AKT1, IL6, JUN, VEGFA and MAPK3 as hub targets. KEGG analyses found that they were mainly enriched in immune related pathway. Next, in vivo experiment, we observed that FLKM ameliorated pathological injury of lung tissue and reduced neutrophil infiltration in rats with LPS-induced pneumonia. And FLKM decreased the concentration of TNF-α and IL-6 in BALF and downregulated the expression of p38MAPK, AKT and VEGFA in lung tissue. Finally, Molecular docking tests showed tight docking of these predicted targeted proteins with key active compounds. Molecular dynamics simulation was employed to assess stability and flexibility of receptor-ligand. Among them, AKT1- stigmasterol bound more stably, and their binding free energies were −47.91 ± 1.62 kcal/mol. This study revealed core compositions and targets for FLKM treating pneumonia and provided integrated pharmacological evidence to support its clinical efficacy.

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“…Accordingly, gentiopicroside increased SIRT1 and decreased acetylation of NF-κB/p65 protein levels in lung tissue of OVA-sensitized mice and decreased the levels of pro-inflammatory mediators in the bronchoalveolar lavage fluid, thus alleviating the pathological changes in lung tissue of OVA-sensitized mice. The effects induced by treatment with gentiopicroside were identical to those observed with resveratrol and partially reversed by treatment with EX-527 [ 106 ]. These results suggest that the anti-allergic effects of gentiopicroside are due in part to its ability to induce SIRT1 expression and thus inhibit NF-κB.…”

Section: Monoterpenes and Sirtsmentioning

confidence: 94%

“… Compound Structure Model SIRT1 Expression Outcome Ref. Gentio-picroside OVA-induced allergic mouse asthma (20–80 mg/Kg) ↑ Amelioration of OVA-induced inflammation [ 106 ] Oleuropein Avian muscle cells (50 µM) ↑ Induction of mitochondrial biogenesis and decrease of ROS [ 108 ] Growing broiler chicken (0.1–2.5 ppm) ↑ Reduction of muscle oxidative damage [ 109 ] Oleuropein aglycone TgCRND8 mice(50 mg/Kg) MNNG-treated N2a cells (100 µM) ↑ Counteraction of neuronal damage [ 110 ] MNNG, N-methyl-N′-nitro-N-nitrosoguanidine; OVA, ovalbumin. …”

Section: Monoterpenes and Sirtsmentioning

confidence: 99%

Monoterpenes as Sirtuin-1 Activators: Therapeutic Potential in Aging and Related Diseases

Sousa

Mendes

2022

Biomolecules

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Sirtuin 1 (SIRT) is a class III, NAD+-dependent histone deacetylase that also modulates the activity of numerous non-histone proteins through deacylation. SIRT1 plays critical roles in regulating and integrating cellular energy metabolism, response to stress, and circadian rhythm by modulating epigenetic and transcriptional regulation, mitochondrial homeostasis, proteostasis, telomere maintenance, inflammation, and the response to hypoxia. SIRT1 expression and activity decrease with aging, and enhancing its activity extends life span in various organisms, including mammals, and improves many age-related diseases, including cancer, metabolic, cardiovascular, neurodegenerative, respiratory, musculoskeletal, and renal diseases, but the opposite, that is, aggravation of various diseases, such as some cancers and neurodegenerative diseases, has also been reported. Accordingly, many natural and synthetic SIRT1 activators and inhibitors have been developed. Known SIRT1 activators of natural origin are mainly polyphenols. Nonetheless, various classes of non-polyphenolic monoterpenoids have been identified as inducers of SIRT1 expression and/or activity. This narrative review discusses current information on the evidence that supports the role of those compounds as SIRT1 activators and their potential both as tools for research and as pharmaceuticals for therapeutic application in age-related diseases.

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Gentiopicroside ameliorates ovalbumin-induced airway inflammation in a mouse model of allergic asthma via regulating SIRT1/NF-κB signaling pathway

Cited by 21 publications

References 41 publications

Roles of sirtuins in asthma

Roles of sirtuins in asthma

The TCM Preparation Feilike Mixture for the Treatment of Pneumonia: Network Analysis, Pharmacological Assessment and Silico Simulation

Monoterpenes as Sirtuin-1 Activators: Therapeutic Potential in Aging and Related Diseases

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