Genus Kalanchoe (Crassulaceae): A Review of Its Ethnomedicinal, Botanical, Chemical and Pharmacological Properties

Milad, Rola; El-Ahmady, Sherweit H.; Singab, Abdel Nasser B.

doi:10.9734/ejmp/2014/5901

Cited by 66 publications

(67 citation statements)

References 41 publications

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“…However, the limitation could be handled by comparing the spectrum with other previous publications about the active compounds of Kalanchoe pinnata (Lmk) Pers. Rutin, as one compound of flavonoids in this plant has also identified in other research 18,32,33 .…”

Section: Discussionsupporting

confidence: 59%

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2018

IJPSR

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Section: Discussionsupporting

confidence: 59%

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2018

IJPSR

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“…Thirteen bufadienolides (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13), including three glycosides, have been reported from B. pinnatum, B. delagoense, B. daigremontianum, and the hybrid B. daigremontianum x tubiflorum (l " Table 1, Fig. 1), mostly in conjunction with various bioactivities such as insecticidal and cytotoxic properties [11][12][13][14][15][16][17][18][19][20][21][22][23].…”

Section: Bufadienolidesmentioning

confidence: 99%

“…Unauthorized distribution is strictly prohibited.Bryophyllum (see below) [4]. While these reviews describe various compounds and bioactivities, none of them addresses the pharmacological and clinical data that support the therapeutic use of Bryophyllum preparations in European countries.…”

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confidence: 99%

Bryophyllum pinnatum and Related Species Used in Anthroposophic Medicine: Constituents, Pharmacological Activities, and Clinical Efficacy

et al. 2016

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ReviewsThis document was downloaded for personal use only. Unauthorized distribution is strictly prohibited.Bryophyllum (see below) [4]. While these reviews describe various compounds and bioactivities, none of them addresses the pharmacological and clinical data that support the therapeutic use of Bryophyllum preparations in European countries. The present review focuses on B. pinnatum, but the few data available on Bryophyllum daigremontianum, Bryophyllum delagoense, and the hybrid Bryophyllum daigremontianum x tubiflorum have also been included. The German homeopathic pharmacopeia (HAB) 2014 [5] lists the two species B. pinnatum and B. daigremontianum as officinal in its monography "Bryophyllum Rh", and both have been used in AM. B. delagoense was introduced in the 1980s as an anthroposophic medicinal product in Germany, primarily for sedative purposes (Personal communication, Dr. med. Siegward-M. Elsas, see Acknowledgments). Botany

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“…The leaves contain astragalin, 3,8-dimethoxy-4,5,7-trihydroxyflavone, friedelin, epigallocatechin-3-osyringate, luteolin, rutin, kaempferol, quercetin, quercetin-3L-rhamnosido-L-arabino furanoside, quercetin-3-O-diarabinoside, and kaempferol-3-glucoside. 16,21 These multiple compounds might have the synergic effects that reduce lupus nephritis manifestations.…”

Section: Characteristics Of the Aqueous Extract Of Kalanchoe Pinnata mentioning

confidence: 99%

Repairing Effects of Aqueous Extract of Kalanchoe pinnata (Lmk) Pers. on Lupus Nephritis Mice

Indriyanti¹,

Garmana²,

Setiawan³

2018

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Kalanchoe pinnata (Lmk) Pers (KP) has an immunosuppressive effect on delayed-type hypersensitivity test. Based on it, this research aimed to determine the repairing effects of aqueous extract of KP on lupus nephritis mice and identified its active compound. The KP extract profile was determined using UPLC-QTOF-MS/MS instrument. We examined six mice groups consisting of three curative treatment groups, one standard group receiving prednisone, one preventive group receiving KP extract, and one healthy (healthy and untreated) group. At the end of the experiment, we measured the proteinuria and renal histology parameters. To recognize the active compound in the KP profile, we performed in silico assays for the flavonoid compounds to bind to the glucocorticoid receptor. We played in silico tests for the flavonoid compounds to identify the active compound in the KP profile. We found the repairing effect of KP was detected in the kidney, demonstrated by its low proteinuria level and its better tissue structure. In the curative group, the urine protein level and its glomerular inflammation decreased. In the preventive group, the aqueous extract of KP could prevent lupus nephritis manifestations in the kidney. Bryophyllin A is the most active compound of the KP. However, further research is needed to understand the mechanism involved. We conclude, the aqueous extract, especially its bryophyllin A, have beneficial effects in repairing the function and tissue structure of lupus manifestations in mice kidney.

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Genus Kalanchoe (Crassulaceae): A Review of Its Ethnomedicinal, Botanical, Chemical and Pharmacological Properties

Cited by 66 publications

References 41 publications

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Bryophyllum pinnatum and Related Species Used in Anthroposophic Medicine: Constituents, Pharmacological Activities, and Clinical Efficacy

Repairing Effects of Aqueous Extract of Kalanchoe pinnata (Lmk) Pers. on Lupus Nephritis Mice

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