The North Dabie complex zone (NDZ), central China, is a high-T ultrahigh-pressure (UHP) metamorphic terrane. It underwent a complex evolution comprising of multistage metamorphism and multiple anatectic events during the Mesozoic continental collision, characterized by granulite-facies overprinting and a variety of migmatites with different generations of leucosomes. In this contribution, we carried out an integrated study including field investigation, petrographic observations, zircon U-Pb dating, and whole-rock element and Sr-Nd-Pb isotope analysis for the migmatites in the NDZ and their leucosomes and melanosomes. As a result, four groups of leucosomes have been recognized: Group 1 (garnet-bearing leucosome), strongly deformed leucosomes with coarse-grained peritectic garnet; Group 2 (amphibole-rich leucosome), weakly deformed to undeformed amphibole-rich leucosomes with coarse-grained peritectic amphibole and no garnet; Group 3 (amphibole-poor leucosome), weakly deformed to undeformed amphibole-poor leucosomes with minor fine-grained amphibole; Group 4 (K-feldspar-rich leucosome), K-feldspar-rich leucosomes mainly composed of coarse-grained quartz, plagioclase and K-feldspar. Zircon SHRIMP and LA-ICPMS U-Pb dating suggest that the Group 1 leucosomes formed at 209 ± 2 Ma whereas the rest of the leucosome groups (Groups 2–4) occurred between 145–110 Ma, in response to decompression under granulite-facies conditions during the early stage of exhumation, and to heating during post-orogenic collapse, respectively. Furthermore, the garnet-bearing leucosomes were resulted from fluid-absent anatexis related to biotite dehydration melting, while the other three groups of leucosomes were formed during large-scale fluid-present partial melting and coeval migmatization. This migmatization comes from heating from the mountain-root removal and asthenosphere upwelling, together with the influx of fluids derived from country rocks at mid-upper crustal levels. However, all the leucosomes and melanosomes display Pb-isotopic compositions similar to those observed for the NDZ UHP rocks (eclogites and granitic gneisses), suggesting a common source from the Triassic subducted Neoproterozoic lower-crustal rocks. In addition, the Cretaceous partial melting and migmatization began at 143 ± 2 Ma with three age-peaks at 133 ± 3 Ma, 124 ± 3 Ma and 114 ± 7 Ma, respectively.