Natural radionuclides include the 238U and 232Th radioactive families with daughter decay products and 40K potassium. In addition to these, the raw materials may contain man-made radioactive nuclides formed due to accidents at the nuclear facilities and its uncontrolled release into the environment (for example, 137Cs). Reducing the impact of radiation exposure on humans and the environment is an urgent task, both in Russia and abroad, given the rapid quantitative growth of the range, manufacturers, suppliers and consumers of building materials associated with the general trend of urbanization. Currently, there is a large number of studies on the natural and man-made radioactivity of building materials. As a rule, they present disparate and local scientific results, which complicates their accessibility to a wide range of interested parties manufacturers and consumers of construction products. Therefore, it is necessary that information on the radiation and environmental cleanliness of various materials and products was easily accessible to all comers. An information system on the natural and man-made radioactivity of building materials and products should become a tool for solving this problem. The work outlines the principles of creation and practical implementation, structure and content, goals, objectives of the field of destination and application of the information system for natural and man-made radioactivity of building materials and products.