Geographic distribution of Trypanosoma cruzi genotypes detected in chronic infected people from Argentina. Association with climatic variables and clinical manifestations of Chagas disease

Bizai, María Laura; Romina, Peralta; Antonela, Simonetto; Olivera, Verónica; Arias, Evelyn; Josefina, Dalla Costa; Manattini, Silvia; Sione, Walter Fabian; Diana, Fabbro; Diez, Cristina

doi:10.1016/j.meegid.2019.104128

Cited by 11 publications

(11 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, the different groups appear to be adapted to different ambient temperatures. For example, group TcV was more likely to be found in people infected in zones with higher annual temperatures than group TcVI [ 29 ]. According to our results, these differences could be due to the greater ability of some groups to tolerate certain temperatures.…”

Section: Discussionmentioning

confidence: 99%

“…First, previous studies have shown that these strains induce different behavioral changes [ 27 ] and fitness costs [ 28 ] in T. pallidipennis . Second, T. cruzi is divided into several groups and strains, which may be adapted to certain ambient temperatures [ 29 ]. In fact, the development of the different strains is sensitive to temperature in the laboratory [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Higher temperatures reduce the number of Trypanosoma cruzi parasites in the vector Triatoma pallidipennis

et al. 2021

View full text Add to dashboard Cite

Background Relatively little is known about how pathogens transmitted by vector insects are affected by changing temperatures analogous to those occurring in the present global warming scenario. One expectation is that, like their ectothermic vectors, an increase in temperature could reduce their fitness. Here, we have investigated the effect of high temperatures on the abundance of Trypanosoma cruzi parasites during infection in the vector Triatoma pallidipennis. Methods We exposed T. pallidipennis nymphs to two strains (Morelos and Chilpancingo) of T. cruzi. Once infected, the fifth-instar bugs were distributed among three different temperature groups, i.e. 20, 30, and 34 °C, and the resulting parasites were counted when the bugs reached adulthood. Results The number of parasites increased linearly with time at 20 °C and, to a lesser extent, at 30 °C, especially in the Chilpancingo compared to the Morelos strain. Conversely, at 34 °C, the number of parasites of both strains decreased significantly compared to the other two temperatures. Conclusions These results suggest negative effects on the abundance of T. cruzi in T. pallidipennis at high temperatures. This is the first evidence of the effect of high temperatures on a pathogenic agent transmitted by an insect vector in the context of global warming. Further tests should be done to determine whether this pattern occurs with other triatomine species and T. cruzi strains. Graphical abstract

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Higher temperatures reduce the number of Trypanosoma cruzi parasites in the vector Triatoma pallidipennis

et al. 2021

View full text Add to dashboard Cite

show abstract

“…In fact, TcII is the most found DTU in genotyping studies performed in Brazil and is associated to severe chronic cardiac forms and chronic digestive forms [7,14,23]. The TcII and TcVI were found in patients with the chronic cardiac form of Chagas disease in Brazil and in other South American countries, such as Argentina, Bolivia, and Chile [11,14,15,22,23,38,39]. However, most T. cruzi genotyping studies focused on the association between specific DTU genotypes and the cardiac https://doi.org/10.1371/journal.pone.0243008.g003 Table 4.…”

Section: Plos Onementioning

confidence: 99%

“…Regarding the association between T. cruzi genotypes and clinical presentations of chronic Chagas disease, TcI, TcII, TcIV, TcV, and TcVI were identified in patients with chronic cardiac form born in Argentina, Brazil, Bolivia, Colombia, and Venezuela [11,[15][16][17][18][19][20][21][22][23], while TcII, TcV, and TcVI were also identified in patients with the digestive form, particularly in Brazil, Argentina, and Bolivia [16,[22][23][24]. TcIV seems to have a secondary importance in patients with Chagas cardiomyopathy in Colombia and Venezuela [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Association between Trypanosoma cruzi DTU TcII and chronic Chagas disease clinical presentation and outcome in an urban cohort in Brazil

et al. 2020

View full text Add to dashboard Cite

Background The specific roles of parasite characteristics and immunological factors of the host in Chagas disease progression and prognosis are still under debate. Trypanosoma cruzi genotype may be an important determinant of the clinical chronic Chagas disease form and prognosis. This study aimed to identify the potential association between T. cruzi genotypes and the clinical presentations of chronic Chagas disease. Methodology/principal findings This is a retrospective study using T. cruzi isolated from blood culture samples of 43 patients with chronic Chagas disease. From 43 patients, 42 were born in Brazil, mainly in Southeast and Northeast Brazilian regions, and one patient was born in Bolivia. Their mean age at the time of blood collection was 52.4±13.2 years. The clinical presentation was as follows 51.1% cardiac form, 25.6% indeterminate form, and 23.3% cardiodigestive form. Discrete typing unit (DTU) was determined by multilocus conventional PCR. TcII (n = 40) and TcVI (n = 2) were the DTUs identified. DTU was unidentifiable in one patient. The average follow-up time after blood culture was 5.7±4.4 years. A total of 14 patients (32.5%) died and one patient underwent heart transplantation. The cause of death was sudden cardiac arrest in six patients, heart failure in five patients, not related to Chagas disease in one patient, and ignored in two patients. A total of 8 patients (18.6%) progressed, all of them within the cardiac or cardiodigestive forms. Conclusions/significance TcII was the main T. cruzi DTU identified in chronic Chagas disease Brazilian patients (92.9%) with either cardiac, indeterminate or cardiodigestive forms, born at Southeast and Northeast regions. Other DTU found in much less frequency was TcVI (4.8%). TcII was also associated to patients that evolved with heart failure or sudden cardiac arrest, the two most common and ominous consequences of the cardiac form of Chagas disease.

show abstract

“…The parasite Trypanosoma cruzi, the aetiological agent of Chagas disease, is currently classified into seven discrete typing units (DTUs), TcI-TcVI and Tcbat (Zingales et al, 2012). In many endemic areas, mixed infections with different DTUs are common in patients (Rodrigues Dos Santos et al, 2018;Bizai et al, 2020) and reservoirs (Barros et al, 2017). The parasite genetic variability and the genetic background of the host could determine the clinical course of the infection (Messenger et al, 2015) and the treatment effectiveness (Cencig et al, 2012;Díaz et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Differential tissue distribution of discrete typing units after drug combination therapy in experimental Trypanosoma cruzi mixed infection

Strauss¹,

Presti²,

Ramı́rez³

et al. 2021

Parasitology

View full text Add to dashboard Cite

show abstract

Geographic distribution of Trypanosoma cruzi genotypes detected in chronic infected people from Argentina. Association with climatic variables and clinical manifestations of Chagas disease

Cited by 11 publications

References 49 publications

Higher temperatures reduce the number of Trypanosoma cruzi parasites in the vector Triatoma pallidipennis

Higher temperatures reduce the number of Trypanosoma cruzi parasites in the vector Triatoma pallidipennis

Association between Trypanosoma cruzi DTU TcII and chronic Chagas disease clinical presentation and outcome in an urban cohort in Brazil

Differential tissue distribution of discrete typing units after drug combination therapy in experimental Trypanosoma cruzi mixed infection

Contact Info

Product

Resources

About