Geographic stomatitis and psoriasis

Wal, N. van der; Kwast, W.A.M. van der; Dijk, E. van; Waal, I. van der

doi:10.1016/s0901-5027(88)80161-9

Cited by 32 publications

(48 citation statements)

References 16 publications

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“…psoriasis can be proposed when their clinical course runs parallel to that of the skin and is supported by histologic examination [1,2,5,6,8,9].…”

Section: Fig 4 Aspect Histologique De La Lésion (Grossissement Moyementioning

confidence: 99%

“…However, their link with psoriasis remains unproven [7]. Their histologic features are similar to those of a cutaneous psoriasis [3,9,[13][14][15], but the histological distinction between psoriasis and isolated geographic/fissurated tongue cannot be made [11].…”

Section: Fig 4 Aspect Histologique De La Lésion (Grossissement Moyementioning

confidence: 99%

“…Geographic stomatitis is very rare [9,16] and usually shows flattened, circinate, erythematous areas surrounded by a keratotic border [15,17].…”

Section: Fig 4 Aspect Histologique De La Lésion (Grossissement Moyementioning

confidence: 99%

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Oral psoriasis: an atypical case

Curien¹,

Maschino²,

Guillet³

et al. 2012

Med Buccale Chir Buccale

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-Psoriasis is a chronic cutaneous inflammatory disease. We describe the case of a 60-year-old woman presenting both general psoriasis and oral erythemato-erosive lesions. History and histopathology of the lesions tend to prouve a link with her general psoriasis. Local applications of betamethasone provides rapid improvement of the symptomatology. Oral lesions of psoriasis are rare and controversial. There is some evidences that fissurated or geographic tongue present a statistical correlation with skin psoriasis. Our case present unusual features which were never described so far and that could be source of misdiagnosis.

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“…psoriasis can be proposed when their clinical course runs parallel to that of the skin and is supported by histologic examination [1,2,5,6,8,9].…”

Section: Fig 4 Aspect Histologique De La Lésion (Grossissement Moyementioning

confidence: 99%

Section: Fig 4 Aspect Histologique De La Lésion (Grossissement Moyementioning

confidence: 99%

See 1 more Smart Citation

Oral psoriasis: an atypical case

Curien¹,

Maschino²,

Guillet³

et al. 2012

Med Buccale Chir Buccale

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“…When lesions are found only on the tongue, the lesion is referred to as geographic tongue. 2,3 Some authors have observed a relation between geographic stomatitis and immune mediated diseases, including Reiter's syndrome, atopy and psoriasis 3,4 Geographic stomatitis may present with similar clinical, histopathological and genetics patterns to psoriasis, suggesting that this lesion may represent an oral manifestation of psoriasis. [4][5][6][7][8][9] The purpose of this article is to report one case of geographic stomatitis and to discuss a possible connection between this condition and psoriasis.…”

Section: Introductionmentioning

confidence: 99%

Geographic stomatitis: an oral manifestation of psoriasis?

Picciani¹,

Silva-Júnior²,

Carneiro³

et al. 2012

J Dermatol Case Rep

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Background: Geographic stomatitis is an uncommon oral lesion that presents similar clinical, histopathological and genetic features as those of psoriasis. These findings suggest that this lesion may actually represent an oral manifestation of psoriasis. We report one case of geographic stomatitis and discuss a possible connection between this condition and psoriasis.Main observations: A 37-year-old woman presented with red patches, surrounded by a white border on the labial mucosa and a positive family history of psoriasis. Histopathological examination, immunohistochemical analysis with antibodies against CD4, CD8, CD20, CD68, CD31, and Ki-67 and HLA-A*, -B*, -C*, -DRB1*, -DQA1* and -DQB1* genotyping were performed. Histopathological examination revealed parakeratosis, marked elongation of rete ridges with acanthosis and clubbing, exocytosis, Munro microabscesses, pustule of Kogoj, dilated tortuous vessels at the tip of dermal papillae, and predominant superficial and perivascular lymphocytic chronic inflammatory cell infiltrate. Immunohistochemistry analysis revealed a predominant T-cell subepithelial infiltrate. Based on the referred clinicopathological findings and in the absence of cutaneous lesions, the diagnosis of geographic stomatitis was confirmed. Conclusions:This case and theoretical data indicate that geographic stomatitis may be an oral manifestation of psoriasis. Moreover, to improve our understanding, psoriatic patients should routinely undergo a detailed oral examination and patients with geographic stomatitis should routinely be submitted to a cutaneous routine examination. (J Dermatol Case Rep.

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“…[15][16][17][18] This is partly because of the general observation, that signs of a possible psoriatic involvement of the oral mucosa are only seen in rare cases, mostly in conjunction with pustular skin manifestations of psoriasis. 19 -22 In such cases, the lips may show an exfoliative psoriatic cheilitis, and usually the tongue presents with an exfoliatio areata linguae (ie, a so-called geographical tongue or benign migratory glossitis).…”

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confidence: 99%

Suprabasal Overexpression of the hsRPB7 Gene in Psoriatic Epidermis as Identified by a Reverse Transcriptase-Polymerase Chain Reaction Differential Display Model Comparing Psoriasis Plaque Tissue with Peritonsillar Mucosa

Böckelmann

Neugebauer

Paseban

et al. 2001

The American Journal of Pathology

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In psoriasis an etiopathogenetic vicious circle is nowadays hypothesized that the disease is triggered by skin-specific autoantigen structures, the expression and accessibility of which are positively correlated with the intensity of the hyperproliferation and inflammation in the epidermopapillary compartment driven by autoreactive T cells. Despite the close microanatomical relation between skin and mucosa, clinicians have always been intrigued by the observation that psoriatic affection of the mucosa, if at all existing, is only seen as very rare events in the lips and tongue sparing buccopharyngeal sites. This prompted us to establish an experimental model system comparing psoriatic-involved skin and peritonsillar mucosa from tonsillectomies by a reverse transcriptase-polymerase chain reaction/differential display strategy. Among more than 60 cDNA species to be displayed in psoriasis, but missing in peritonsillar mucosa, one species was identified as coding for the RNA polymerase IIA seventh subunit (hsRPB7 gene) as a most critical factor for DNA to RNA transcription. Immunohistochemistry showed a hitherto unknown, distinctive pattern of hsRPB7 expression that was 1) tissue type-dependent with a surplus in skin keratinocytes and a near absence in peritonsillar mucosa, 2) tightly regulated by the keratinocyte differentiation process with a sharp suprabasal up-regulation in contrast to a basal down-regulation, and 3) substantially augmented in psoriatic-involved skin as compared to normal and psoriatic uninvolved skin. Keratinocytes of actinic keratoses also showed a strong hsRPB7 expression that however did not strictly spare the basal cell layer presumably reflecting the disturbed intraepidermal stratification because of the premalignant status of these precancerous lesions. The etiology of psoriasis is still unknown.

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Geographic stomatitis and psoriasis

Cited by 32 publications

References 16 publications

Oral psoriasis: an atypical case

Oral psoriasis: an atypical case

Geographic stomatitis: an oral manifestation of psoriasis?

Suprabasal Overexpression of the hsRPB7 Gene in Psoriatic Epidermis as Identified by a Reverse Transcriptase-Polymerase Chain Reaction Differential Display Model Comparing Psoriasis Plaque Tissue with Peritonsillar Mucosa

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