Geographical, Sex, Age, and Seasonal Differences in Serum Manganese Status Among Chinese Adults with Hypertension

Chen, Hong; Zhixin, Cui; Lu, Wenhai; Wang, Ping; Jia, Wang; Zhou, Ziyi; Zhang, Nan; Wang, Zhuo; Lin, Tengfei; Song, Yun; Liu, Lishun; Huang, Xiao; Chen, Ping; Tang, Genfu; Duan, Yong; Zhang, Yuanyuan; Li, Jianping; Zhang, Yan; Huo, Yong; Zhang, Hao; Xu, Xiping; Qin, Xianhui; Yang, Yan

doi:10.1007/s12011-022-03135-4

Cited by 6 publications

(3 citation statements)

References 31 publications

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“…This is probably due the differences in serum manganese levels among Chinese people and people from different geographical locations. The median serum manganese level reported in this study (2.34 µg/L, Table 1) is higher than the median serum manganese levels in a nation-wide survey performed in China (males: 1.60 µg/L; females:1.51 µg/L) [41], which suggests that the participants of the current study had sufficient serum manganese levels. Regarding the role of copper in T2D, a unique finding was noted in our study.…”

Section: Discussioncontrasting

confidence: 77%

Antioxidant Minerals Modified the Association between Iron and Type 2 Diabetes in a Chinese Population

Xu,

Wan,

Shi

et al. 2024

Nutrients

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Inconsistent findings exist regarding the relationship between heme iron intake and type 2 diabetes (T2D) among Western and Eastern populations. Easterners tend to consume a plant-based diet which is abundant in antioxidant minerals. To examine the hypothesis that antioxidant mineral may modify the relationship between iron and T2D, we performed a case–control study by measuring the serum mineral levels in 2198 Chinese subjects. A total of 2113 T2D patients and 2458 controls were invited; 502 T2D patients and 1696 controls were finally analyzed. In the total population, high serum iron showed a positive association with T2D odds (odds ratio [OR] = 1.27 [1.04, 1.55]); high magnesium (OR = 0.18 [0.14, 0.22]), copper (OR = 0.27 [0.21, 0.33]), zinc (OR = 0.37 [0.30, 0.46]), chromium (OR = 0.61 [0.50, 0.74]), or selenium concentrations (OR = 0.39 [0.31, 0.48]) were inversely associated with T2D odds. In contrast, in individuals with higher magnesium (>2673.2 µg/dL), zinc (>136.7 µg/dL), copper (>132.1 µg/dL), chromium (>14.0 µg/dL), or selenium concentrations (>16.8 µg/dL), serum iron displayed no association with T2D (p > 0.05). Serum copper and magnesium were significant modifiers of the association between iron and T2D in individuals with different physiological status (p < 0.05). Our findings support the idea that consuming a diet rich in antioxidant minerals is an effective approach for preventing T2D.

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Section: Discussioncontrasting

confidence: 77%

Antioxidant Minerals Modified the Association between Iron and Type 2 Diabetes in a Chinese Population

Xu,

Wan,

Shi

et al. 2024

Nutrients

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“…A cross-sectional study of 957 participants from the Gulf Long-Term Follow-up Study showed that Mn was positively associated with the risk of hypertension ( 9 ), while a negatively association of urinary Mn with blood pressure was found in another study ( 8 ). Another cross-sectional study included 2,597 Chinese adults with hypertension showed that blood Mn levels were associated with age, region and season, but not with SBP (β = −0.01, P > 0.05) and DBP (β = 0.00, P > 0.05) ( 33 ). In the present study, no significant differences in whole blood Mn levels between hypertensive and non-hypertensive subjects were found, however, a positive trend and association of blood Mn with the risk of hypertensive, levels of SBP and DBP were observed in single-metal model (both P trend < 0.05), and this trend is maintained in levels of SBP and DBP after FDR-adjustments (both P FDR < 0.10).…”

Section: Discussionmentioning

confidence: 99%

Association of multi-metals with the risk of hypertension and the interaction with obesity: A cross-sectional study in China

et al. 2023

Front. Public Health

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BackgroundEnvironmental exposure to multiple metals have been inconsistently associated with hypertension. Obesity is an important independent risk factor for hypertension, and few studies have assessed the interaction between obesity and metals in this context. We aimed to clarify their association and interaction.MethodsThis cross-sectional study included 3,063 adults from 11 districts or counties, Guangdong. We measured the whole blood levels of 13 metals and used multipollutant-based statistical methods to analyze the association of metals with hypertension. The interaction between metals and obesity on hypertension was assessed on additive and multiplicative scales.ResultsFour metals (manganese, arsenic, cadmium, and lead) were significantly associated with hypertension risk, five metals (manganese, zinc, arsenic, cadmium, and lead) were related to elevated SBP levels, five metals (manganese, zinc, selenium, cadmium, and lead) were associated with elevated DBP levels in single-metal model. Manganese remained significantly related to hypertension risk [odds ratio, 1.35 (1.02–1.78)] after adjusting for these four metals. Significant positive dose-response relationships between manganese, arsenic, cadmium, lead and hypertension risk were observed (P for overall < 0.001, P for non-linearity > 0.05). Compared with those in the lowest quartile, participants in the highest manganese quartile had a 2.83 mmHg (95% Cl: 0.71–4.96) (PFDR = 0.040) higher level of SBP. Individuals in the highest quartiles of zinc and lead had a 1.45 mmHg (0.10–2.81) (PFDR = 0.033) and 2.06 mmHg (0.59–3.53) (PFDR = 0.020) higher level of DBP, respectively. The negative interactions between cadmium, lead and obesity influences hypertension risk. BKMR analysis showed a significant joint effect of manganese, arsenic, cadmium and lead on hypertension when the concentrations of four metals were at or above their 55th percentile compared to their median values.ConclusionsThe combined effect of four metals (manganese, arsenic, cadmium and lead) were associated with the prevalence of hypertension. Potential interaction effects of cadmium, lead and obesity on hypertension risk may exist. Further cohort studies in larger population are needed to clarify these findings.

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“…First, 900 participants were randomly selected from nine provinces and stratified by province, who were enrolled from June to August 2017 and had complete screening records (physical exam, questionnaire, and biological samples). Second, another 1,709 participants were randomly selected from 14 provinces (including the 9 provinces in the first sampling set plus an additional 5 provinces) and stratified by province, sex, and age groups, who were enrolled from February 2017 to May 2018 and had complete screening records ( 25 ). Finally, after combining the two subsamples, a total of 2,599 participants from all 14 provinces without duplication, were included in our current study, excluding those with missing values of Se ( Supplementary Figure 1 ).…”

Section: Methodsmentioning

confidence: 99%

A Cross-Sectional Study of the Distribution Patterns and Potential Determinants in Plasma Selenium Status Among Chinese Adults With Hypertension

et al. 2022

Self Cite

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Selenium (Se) is an essential trace element in selenoproteins biosynthesis for the human body and plays an important role in the prevention and control of subsequent cardiovascular disease in adults with hypertension. However, reports on Se status and its potential determinants in populations from different regions of China are limited, especially data on adults with hypertension, a high-risk group more vulnerable to oxidative stress. Thus, we conducted a cross-sectional study from February 2017 to May 2018 of 2,599 participants (1,389 men and 1,210 women) on middle-aged to elderly adults with hypertension with a mean age of 63.1 years (SD 13.3) from 14 provinces of China and aimed to examine the relationship of plasma Se status with demographic characteristics and lifestyles. Overall, the male participants (mean value 75.0 μg/L) tended to have higher plasma Se concentrations than the female participants (73.7 μg/L) when controlling for relevant factors. There were significant differences among regions, and in age and body mass index (BMI) in plasma Se distribution, and plasma Se concentrations were significantly lower among those in the regions with relatively lower Se, aged 60 years or older, and with BMI lower than 28 kg/m2. Moreover, a higher frequency of meat consumption (1–2 or ≥3 times/week vs. <1 time/week) was significantly associated with higher plasma Se concentrations in men and women, and male alcohol drinkers had significantly higher plasma Se concentrations than non-alcohol drinkers. Adequate consumption of fruits and vegetables (0.5–1.5 kg/week) was associated with higher plasma Se concentrations among women, but was associated with relatively lower plasma Se concentrations in men. Our results indicated relatively low plasma Se status in Chinese adults with hypertension from 14 provinces, while specific factors including geographic, demographic, and lifestyle characteristics and blood pressure were significantly associated with plasma Se status in this hypertensive population. In addition, more studies are required to further evaluate dietary structure and other lifestyle factors that influence circulating Se status.

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Geographical, Sex, Age, and Seasonal Differences in Serum Manganese Status Among Chinese Adults with Hypertension

Cited by 6 publications

References 31 publications

Antioxidant Minerals Modified the Association between Iron and Type 2 Diabetes in a Chinese Population

Antioxidant Minerals Modified the Association between Iron and Type 2 Diabetes in a Chinese Population

Association of multi-metals with the risk of hypertension and the interaction with obesity: A cross-sectional study in China

A Cross-Sectional Study of the Distribution Patterns and Potential Determinants in Plasma Selenium Status Among Chinese Adults With Hypertension

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