Geographical variation in the chemical composition, anti-inflammatory activity of the essential oil, micromorphology and histochemistry of Schinus terebinthifolia Raddi

Marangoni, Janaine Alberto; Velasques, Jannaína; Kassuya, Cândida Aparecida Leite; Oliveira, Pedro Cruz de; Santos, Sidney Mariano dos; Cardoso, Cláudia Andréa Lima; Mussury, Rosilda Mara; Silva, Marcia Espíndola da; Machado, Camila Dias; Budel, Jane Manfron; Formagio, Anelise Samara Nazari

doi:10.1016/j.jep.2022.115786

Cited by 7 publications

(4 citation statements)

References 33 publications

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“…Although their skeleton has only 15 carbon atoms, their structures have various configurations. In this study, the configuration of the sesquiterpenoids was confirmed according to the natural product chemistry series “Monoterpenes and Sesquiterpenes Chemistry” edited by Shi Yanping ( Shi, 2008 ; Marangoni et al, 2022 ). A total of 81 sesquiterpenoids were detected from the 4 forms of agarwood.…”

Section: Resultsmentioning

confidence: 85%

Utilizing metabolomics and network analysis to explore the effects of artificial production methods on the chemical composition and activity of agarwood

Hou,

Feng,

Sun

et al. 2024

Front. Pharmacol.

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Introduction: Agarwood is a traditional aromatic southern medicine. It has a long history of being used in traditional Chinese aromatherapy to treat insomnia, anxiety and depression. Due to the scarcity of wild resources, people have planted trees successfully and begun to explore various agarwood-inducing techniques. This study comparative analysis of volatile metabolites in agarwood produced by various inducing techniques and its potential sleep-promoting, anti-anxiety and anti-depressant network pharmacological activities. Methods: A total of 23 batches of two types of agarwood were collected, one of which was produced by artificial techniques, including 6 batches of TongTi (TT) agarwood produced by “Agar-Wit” and 6 batches of HuoLao (HL) agarwood produced by “burning, chisel and drilling”, while the other was collected from the wild, including 6 batches of BanTou (BT) agarwood with trunks broken due to natural or man-made factors and 5 batches of ChongLou (CL) agarwood with trunks damaged by moth worms. The study employed metabolomics combined with network analysis to compare the differences in volatile metabolites of agarwood produced by four commonly used inducing techniques, and explored their potential roles and possible action targets in promoting sleep, reducing anxiety, and alleviating depression. Results: A total of 147 volatile metabolites were detected in agarwood samples, mainly including small aromatic hydrocarbons, sesquiterpenes and 2-(2-phenylethyl) chromone and their pyrolysis products. The results showed composition of metabolites was minimally influenced by the agarwood induction method. However, their concentrations exhibited significant variations, with 17 metabolites showing major differences. The two most distinct metabolites were 6-methoxy-2-(2-phenylethyl) chromone and 6,7-dimethoxy-2-(2-phenylethyl) chromone. Among the volatile metabolites, 142 showed promising potential in treating insomnia, anxiety, and depression, implicating various biological and signaling pathways, predominantly ALB and TNF targets. The top three active metabolites identified were 2-(2-phenylethyl) chromone, 1,5-diphenylpent-1-en-3-one, and 6-methoxy-2-[2-(4'-methoxyphenyl) ethyl] chromone, with their relative content in the four types of agarwood being TT>HL>CL>BT. Conclusion: The differences in the content of 2-(2-phenylethyl) chromones suggest that they may be responsible for the varying therapeutic activities observed in different types of agarwood aromatherapy. This study offers theoretical support for the selection of agarwood in aromatherapy practices.

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Section: Resultsmentioning

confidence: 85%

Utilizing metabolomics and network analysis to explore the effects of artificial production methods on the chemical composition and activity of agarwood

Hou,

Feng,

Sun

et al. 2024

Front. Pharmacol.

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“…It is well known that cultivation in different geographical locations and post-harvest processing can affect the chemical composition of plant products (Marangoni et al, 2022 ). Eleven commercial samples of pink pepper from various suppliers (Table S1) were studied to represent samples from various origins that might have undergone different cultivation, harvest, and post-harvest process to identify a common chemical profile for pink pepper.…”

Section: Resultsmentioning

confidence: 99%

“…Antioxidant (Bendaoud et al, 2010 ; Feriani et al, 2021 ; Kim et al, 2021 ; Oliveira et al, 2020b ), antibacterial (D'Sousa' Costa et al, 2015 ; Linden et al, 2020 ; Salem et al, 2018 ), antifungal (Giordani et al, 2022 ), antidiabetic (Dos Santos da Rocha et al 2019 ; Iwanaga et al, 2019 ), and other bioactivities have been reported. Anti-inflammatory properties, for example, have been linked to the composition of polyphenols, as well as monoterpenes and sesquiterpenes in the essential oil (Feriani et al, 2020 ; Formagio et al, 2011 ; Kim et al, 2021 ; Marangoni et al, 2022 ; Rosas et al, 2015 ; Yueqin et al, 2003 ).…”

Section: Introductionmentioning

confidence: 99%

Chemical and cytotoxicity profiles of 11 pink pepper (Schinus spp.) samples via non-targeted hyphenated high-performance thin-layer chromatography

Mügge

Morlock

2023

Metabolomics

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Introduction Pink pepper is a worldwide used spice that corresponds to the berries of two species, Schinus terebinthifolia Raddi or S. molle L. (Anacardiaceae). Toxic and allergic reactions by ingestion or contact with these plants were reported, and classical in vitro studies have highlighted the cytotoxic properties of apolar extracts from the fruits. Objectives Perform a non-targeted screening of 11 pink pepper samples for the detection and identification of individual cytotoxic substances. Methods After reversed-phase high-performance thin-layer chromatography (RP-HPTLC) separation of the extracts and multi-imaging (UV/Vis/FLD), cytotoxic compounds were detected by bioluminescence reduction from luciferase reporter cells (HEK 293 T-CMV-ELuc) applied directly on the adsorbent surface, followed by elution of detected cytotoxic substance into atmospheric-pressure chemical ionization high-resolution mass spectrometry (APCI-HRMS). Results Separations for mid-polar and non-polar fruit extracts demonstrated the selectivity of the method to different substance classes. One cytotoxic substance zone was tentatively assigned as moronic acid, a pentacyclic triterpenoid acid. Conclusion The developed non-targeted hyphenated RP-HPTLC–UV/Vis/FLD–bioluminescent cytotoxicity bioassay–FIA–APCI-HRMS method was successfully demonstrated for cytotoxicity screening (bioprofiling) and respective cytotoxin assignment.

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“…terebinthifolia is a species found in the Caatinga, Cerrado, Mata Atlântica, and Pampa biomes (Silva-Luz et al 2020), with remarkable potential for timber production, ornamental use, degraded area rehabilitation, and reforestation purposes. It is particularly recognized for its fruit, Brazilian pepper, which is used in culinary endeavors (Marangoni et al 2023).…”

Section: Study Speciesmentioning

confidence: 99%

Understanding the Temperature Range for Foliar Development of Neotropical Forest Species during the Seedling Stage: Implications for Biology and Ecology

Araújo,

Martins,

Lyra

et al. 2023

Preprint

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This study aimed to estimate the cardinal temperatures for the foliar development of seedlings from four forest species native to Brazilian biomes: Handroanthus heptaphyllus, Tabebuia roseoalba, Ceiba speciosa, and Schinus terebinthifolia. An experiment was conducted with ten sowing times between December 2019 and April 2021. Seven methods were employed to estimate the inferior cardinal temperature, the phyllochron concept for the optimal temperature, and mathematical models for the superior temperature. The results indicated significant variations in the inferior cardinal temperatures among the four species, ranging from 9.8°C to 11.5°C, as well as distinct optimal temperatures ranging from 22.7°C to 25.7°C. Furthermore, disparities were observed between species and sowing times concerning the determination of the phyllochron, with Ceiba speciosa exhibiting an average phyllochron ranging from 75.6 to 246.2 ºday-1. These findings offer valuable insights into the biological and ecological aspects of native forest species and enhance our understanding of key parameters for modeling vegetal growth. However, the limited availability of species-specific information in the Brazilian biome raises concerns regarding the applicability of these models. In conclusion, this study successfully estimates the cardinal temperatures (inferior, optimal, and superior) for foliar development of four important forest species native to Brazilian biomes, thereby contributing to the knowledge base of forestry research.

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Geographical variation in the chemical composition, anti-inflammatory activity of the essential oil, micromorphology and histochemistry of Schinus terebinthifolia Raddi

Cited by 7 publications

References 33 publications

Utilizing metabolomics and network analysis to explore the effects of artificial production methods on the chemical composition and activity of agarwood

Utilizing metabolomics and network analysis to explore the effects of artificial production methods on the chemical composition and activity of agarwood

Chemical and cytotoxicity profiles of 11 pink pepper (Schinus spp.) samples via non-targeted hyphenated high-performance thin-layer chromatography

Understanding the Temperature Range for Foliar Development of Neotropical Forest Species during the Seedling Stage: Implications for Biology and Ecology

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