Higher education is important for economic growth especially for the rapid development of regions. Using different approaches in the education process develops skills that can be used in both science and practical moments. Compelling both of these methods of study is the key for regional growth for economically developing counties like Bulgaria. The scientific approach of study is not useful for that moment of economic development. The reason is hidden in low investment opportunities in innovations for small and medium-sized enterprises and scarce of free cash. That is why businesses want from universities graduated students with practical experience. Often this requirement is impossible because of the specific business activities and additional teaching is needed. In that case, the dual approach will be the best opportunity. This approach includes a practical aspect of the science and simulation it with real operations. Students in the field of regional development must have complex knowledge in the area of economic, social, politics, and geography. These areas of study help for future regional economic growth. Now the pandemic situation in the world put higher education in online mode. The universities moved to e-learning platforms like Moodle, Teams, Zoom, etc. The main problem is related to a few obstacles. First, most of the universities did not use the full functions of that platforms. Second, most of the teachers are not learned how to use them. Third e-learning processes have weak spotscheating, non-direct contact with the students, etc. Fourth the main challenge would be the quality of the teaching and learning.