Geomagnetic field effect on cardiovascular regulation

Gmitrov, Juraj; Gmitrova, A.

doi:10.1002/bem.10173

Cited by 47 publications

(45 citation statements)

References 30 publications

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“…Such speculations are consistent with apparent night-to-night temporal window effects for the influence of GMS on melatonin [16,93,98,99]. In contrast, other stress responses may be influenced more immediately by geomagnetic disturbances, as evidenced by reports of changes to CV parameters on the day of GMS [29,100], rather than such effects being purely downstream of melatonin disturbances (e.g. the day after the GMS).…”

Section: Magnetosense -Hpa Interactions: Two Models (A) a Generalizedsupporting

confidence: 60%

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Are stress responses to geomagnetic storms mediated by the cryptochrome compass system?

Close¹

2012

Proc. R. Soc. B.

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A controversial body of literature demonstrates associations of geomagnetic storms (GMS) with numerous cardiovascular, psychiatric and behavioural outcomes. Various melatonin hypotheses of GMS have suggested that temporal variation in the geomagnetic field (GMF) may be acting as an additional zeitgeber (a temporal synchronizer) for circadian rhythms, with GMS somehow interfering with the hypothesized system. The cryptochrome genes are known primarily as key components of the circadian pacemaker, ultimately involved in controlling the expression of the hormone melatonin. Cryptochrome is identified as a clear candidate for mediating the effect of GMS on humans, demonstrating the prior existence of several crucial pieces of evidence. A distinct scientific literature demonstrates the widespread use of geomagnetic information for navigation across a range of taxa. One mechanism of magnetoreception is thought to involve a light-dependent retinal molecular system mediated by cryptochrome, acting in a distinct functionality to its established role as a circadian oscillator. There is evidence suggesting that such a magnetosense-or at least the vestiges of it-may exist in humans. This paper argues that cryptochrome is not acting as secondary geomagnetic zeitgeber to influence melatonin synthesis. Instead, it is hypothesized that the cryptochrome compass system is mediating stress responses more broadly across the hypothalamic -pituitary-adrenal (HPA) axis (including alterations to circadian behaviour) in response to changes in the GMF. Two conceptual models are outlined for the existence of such responses-the first as a generalized migrational/dispersal strategy, the second as a stress response to unexpected signals to the magnetosense. It is therefore proposed that GMS lead to disorientation of hormonal systems in animals and humans, thus explaining the effects of GMS on human health and behaviour.

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Section: Magnetosense -Hpa Interactions: Two Models (A) a Generalizedsupporting

confidence: 60%

“…However, complex feedback between neuroendocrine systems [57] could, for example, compound impacts on the CV systems, involving both immediate and melatonin-mediated interactions (e.g. see discussion in Gmitrov & Gmitrova [29]). …”

Section: Magnetosense -Hpa Interactions: Two Models (A) a Generalizedmentioning

confidence: 99%

Are stress responses to geomagnetic storms mediated by the cryptochrome compass system?

Close¹

2012

Proc. R. Soc. B.

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“…SMF application to the throat (carotid sinus baroreceptor) region produced a protective effect on baroreceptors, reversing the BRS decrease induced by GMF disturbance [Gmitrov and Ohkubo, 2002b;Gmitrov and Gmitrova, 2004]. One proposed transduction mechanism of the SMF effect on baroreceptor activity suggests that SMF may modulate baroreceptor membrane Ca 2þ channel permeability and NO production [Gmitrov and Ohkubo, 2002b].…”

Section: Introductionmentioning

confidence: 97%

Decreased plasma levels of nitric oxide metabolites, angiotensin II, and aldosterone in spontaneously hypertensive rats exposed to 5 mT static magnetic field

Okano

Masuda

Ohkubo

2005

Bioelectromagnetics

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Previously, we found that whole body exposure to static magnetic fields (SMF) at 10 mT (B(max)) and 25 mT (B(max)) for 2-9 weeks suppressed and delayed blood pressure (BP) elevation in young, stroke resistant, spontaneously hypertensive rats (SHR). In this study, we investigated the interrelated antipressor effects of lower field strengths and nitric oxide (NO) metabolites (NO(x) = NO(2)(-) + NO(3)(-)) in SHR. Seven-week-old male rats were exposed to two different ranges of SMF intensity, 0.3-1.0 mT or 1.5-5.0 mT, for 12 weeks. Three experimental groups of 20 animals each were examined: (1) no exposure with intraperitoneal (ip) saline injection (sham-exposed control); (2) 1 mT SMF exposure with ip saline injection (1 mT); (3) 5 mT SMF exposure with ip saline injection (5 mT). Arterial BP, heart rate (HR), skin blood flow (SBF), plasma NO metabolites (NO(x)), and plasma catecholamine levels were monitored. SMF at 5 mT, but not 1 mT, significantly suppressed and retarded the early stage development of hypertension for several weeks, compared with the age matched, unexposed (sham exposed) control. Exposure to 5 mT resulted in reduced plasma NO(x) concentrations together with lower levels of angiotensin II and aldosterone in SHR. These results suggest that SMF may suppress and delay BP elevation via the NO pathways and hormonal regulatory systems.

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“…Scientists have shown that healthy people in isolation from the magnetic field (MF) significantly increases their capillary blood flow and reduces the diastolic blood pressure [8]. Several laboratory studies have demonstrated significant negative correlations between baroreflex sensitivity and MF changes [9]. The reduction of baroreflex sensitivity may lead to higher mortality after ACS episode [10].…”

Section: Introductionmentioning

confidence: 99%

The local earth magnetic field changes impact on weekly hospitalization due to unstable angina pectoris

Žiubrytė¹,

Jaruševičius²,

Landauskas³

et al. 2018

J., complex., health sci.

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Abstract.Objectives: Acute coronary syndrome as an acute oxygenated blood deprivation to the heart muscle due to atherosclerotic plaque rupture in the coronary artery followed by thrombosis is possibly associated with changes in the Earth's local time varying magnetic field as they strongly influence hormonal and other regulatory systems' activity. This study analyses the correlation between prevalence of the acute coronary syndrome and the changes in the local time varying aspects of the magnetic field. Methods: Seven-hundred patients admitted to Cardiology Department of Hospital of Lithuanian University of Health Sciences Kaunas Clinics within 2016 due to acute coronary syndrome were retrospectively included into the study. The number of cases per week was compared with the weekly changes of the local Earth magnetic field. The one-year period was divided into two periods: the first-half of the year (weeks 1 to 26) and the second-half of the year (weeks 27 to 52) and more detailed analyses were performed accordingly to the significance of the left main artery lesion. Mean power of local magnetic field fluctuations in Lithuania, measured in pT2 in five different frequency ranges where overlaps between the Schumann resonance and EEG frequency ranges (named as SDelta (0-3.5 Hz), STheta (3.5-7 Hz), SAlpha (7-15 Hz), SBeta (15-32 Hz) and SGamma (32-66 Hz) to distinguish them from the EEG bands). Results: Statistically significant weak and moderate correlations between weekly prevalence of acute coronary syndrome admissions and the magnetic field intensities changes were found. Higher intensities in the SBeta and SGamma ranges were associated with a higher number of admissions throughout the year in females and the SGamma range was associated with higher number of admission only during the second-half of the year in males. A higher intensity magnetic field in SDelta, STheta, SAlpha and SBeta ranges was associated with a higher admissions number due to left main artery lesions in males, while a higher intensity in the SGamma range was associated with higher number of admissions due to left main artery lesions in females through the year. Conclusion: Significant correlation between acute coronary syndrome and changes in the local Earth time varying magnetic field intensities was found. Some frequency ranges are associated with an episode of an acute coronary syndrome. Left main artery lesions significantly correlated with magnetic field changes in most of the frequency ranges in males while only one of the frequency ranges in females.

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Geomagnetic field effect on cardiovascular regulation

Cited by 47 publications

References 30 publications

Are stress responses to geomagnetic storms mediated by the cryptochrome compass system?

Are stress responses to geomagnetic storms mediated by the cryptochrome compass system?

Decreased plasma levels of nitric oxide metabolites, angiotensin II, and aldosterone in spontaneously hypertensive rats exposed to 5 mT static magnetic field

The local earth magnetic field changes impact on weekly hospitalization due to unstable angina pectoris

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