Geometric and Compositional Appearance of Atheroma in an Angiographically Normal Carotid Artery in Patients with Atherosclerosis

Dong, Li; Underhill, Hunter R.; Yu, Wei; Ota, Hideki; Hatsukami, Thomas S.; Gao, Ting; Zhang, Z.; Oikawa, Minako; Zhao, Xue Qiao; Yuan, Chun

doi:10.3174/ajnr.a1793

Cited by 51 publications

(40 citation statements)

References 31 publications

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“…However, the vulnerable plaques are commonly observed in carotid arteries without measurable stenosis (Dong et al, 2009). It is proposed that the atherosclerotic lesions that are at high risk of rupture and may cause clinical symptoms can be identified by their morphology, such as unstable fibrous cap, necrotic core, intimal calcification, and intraplaque hematoma (Bassiouny et al, 1997;Davies & Thomas, 1985;Falk, 1999;Fuster et al, 1990).…”

Section: Discussionmentioning

confidence: 97%

A Modified Rabbit Model of Carotid Atherosclerotic Plaque Suitable for the Stroke Study and MRI Evaluation

Fei

Tong

Yifeng

et al. 2011

International Journal of Neuroscience

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In order to induce a modified rabbit model of carotid atherosclerotic plaque suitable for the stroke study and to evaluate the lesion with magnetic resonance imaging (MRI). Eight rabbits of group A were fed with high-fat diet only. Atherosclerosis at the right common carotid artery was induced in rabbits of group B (n = 12) by high-fat diet and balloon catheter injury to the endothelium 4 weeks later. The rabbits were examined in vivo with a 1.5-T MRI. After 4 weeks on the high-fat diet, the serum lipid levels were markedly increased, which became significantly higher than the baseline levels. The lesions on both MRI and histology were remarkable. One week after balloon injury, the signal of injured right common carotid was higher on all the contrast-weighted images than the left side. The extent of abnormal signal was reduced 9 weeks after balloon injury. Hemorrhage was detected on all the contrast-weighted images. In conclusion, the rabbit model established by the authors is such a feasible one to the study of stroke caused by carotid atherosclerosis.

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Section: Discussionmentioning

confidence: 97%

A Modified Rabbit Model of Carotid Atherosclerotic Plaque Suitable for the Stroke Study and MRI Evaluation

Fei

Tong

Yifeng

et al. 2011

International Journal of Neuroscience

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“…The MRI studies of persons with asymptomatic, minimal carotid stenosis have demonstrated a surprisingly high prevalence of carotid plaques with IPH (19,20) and highlight the limitation of stenotic severity as the principal criterion for disease assessment. predict the presence of carotid IPH, and indicated that plaque burden and the size of plaque features such as the lipid-rich necrotic core were more strongly associated with IPH presence than with the severity of luminal narrowing.…”

Section: See Page 416mentioning

confidence: 99%

What Will Noninvasive Carotid Atherosclerosis Imaging Show Us About High-Risk Coronary Plaques?

Yuan

Polissar²,

Hatsukami

2011

Journal of the American College of Cardiology

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“…31 In a recent study, Dong et al found a surprisingly high prevalence of complex atherosclerotic plaques in carotid arteries with no stenosis. 32 Therefore, in vivo MRI is able to discriminate between the specific histological subtype of carotid plaque as proposed by the AHA, thus being able to stratify intermediate to advanced carotid atherosclerotic lesions and distinguish between vulnerable and stable plaques. 8,33 The main advantages of this imaging tool include, beyond extensive histological validation for carotid atherosclerotic plaque characterization, its superior specificity for tissue composition assessment and the lack of ionizing radiation exposure during the procedure.…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

Low-Density Carotid Plaques and the Risk of Stroke

Chițu¹,

Benedek²,

Raț³

et al. 2017

Journal of Interdisciplinary Medicine

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Ischemic stroke is the second cause of death worldwide, and at least a quarter of all ischemic strokes are associated with carotid atherosclerotic disease, the diagnosis of which relies primarily on imaging methods. Traditional risk assessment in carotid atherosclerotic disease has long been based on the measurement of stenosis severity, but there is strong evidence that only stenosis grading falls short in predicting near-future events. Moreover, numerous histopathologic studies gathered increasing evidence that plaque vulnerability depends on its composition and morphology, therefore, the new concept of "vulnerable plaque" analysis is necessary, independent of the carotid narrowing. Follow-up studies concluded that the presence of a large-lipid necrotic core and thin fibrous cap are significantly more likely to result in future ischemic events and thereby are hallmarks for unstable lesions. Under these conditions, magnetic resonance imaging (MRI) and multi-detector computed tomography (MDCT) characterization of specific plaque properties can provide additional information on ischemic stroke risk that are not provided by the simple measurement of luminal stenosis. Therefore, besides the stenosis degree, plaque morphology assessment using noninvasive methods could be useful to identify rupture-prone plaques and may be a suitable prognosis tool that will help improve risk stratification and the effectiveness of therapeutic strategies.

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Geometric and Compositional Appearance of Atheroma in an Angiographically Normal Carotid Artery in Patients with Atherosclerosis

Cited by 51 publications

References 31 publications

A Modified Rabbit Model of Carotid Atherosclerotic Plaque Suitable for the Stroke Study and MRI Evaluation

A Modified Rabbit Model of Carotid Atherosclerotic Plaque Suitable for the Stroke Study and MRI Evaluation

What Will Noninvasive Carotid Atherosclerosis Imaging Show Us About High-Risk Coronary Plaques?

Low-Density Carotid Plaques and the Risk of Stroke

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