Geometric structure design of passive label-free microfluidic systems for biological micro-object separation

Tang, Hao; Niu, Jiaqi; Jin, Han; Lin, Shujing; Cui, Daxiang

doi:10.1038/s41378-022-00386-y

Cited by 36 publications

(20 citation statements)

References 208 publications

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“…In passive separation techniques, microfluidic devices use the forces and interactions between molecules, cells and particles, and the flow field in the microchannels to separate the target samples without any external forces. [ 45 ] Table 1 summarizes some critical parameters like channel structure, surface modification, separated molecules, and chip material type used in the chip fabrication. [ 36,46–73 ] Here, the primary methods used for passive molecular separation in the last decade are listed and discussed in the order listed in the table.…”

Section: Microfluidic‐based Separation Methodsmentioning

confidence: 99%

Molecular Separation by Using Active and Passive Microfluidic chip Designs: A Comprehensive Review

Ebrahimi,

Icoz,

Didarian

et al. 2023

Adv Materials Inter

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Separation and identification of molecules and biomolecules such as nucleic acids, proteins, and polysaccharides from complex fluids are known to be important due to unmet needs in various applications. Generally, many different separation techniques, including chromatography, electrophoresis, and magnetophoresis, have been developed to identify the target molecules precisely. However, these techniques are expensive and time consuming. “Lab‐on‐a‐chip” systems with low cost per device, quick analysis capabilities, and minimal sample consumption seem to be ideal candidates for separating particles, cells, blood samples, and molecules. From this perspective, different microfluidic‐based techniques have been extensively developed in the past two decades to separate samples with different origins. In this review, “lab‐on‐a‐chip” methods by passive, active, and hybrid approaches for the separation of biomolecules developed in the past decade are comprehensively discussed. Due to the wide variety in the field, it will be impossible to cover every facet of the subject. Therefore, this review paper covers passive and active methods generally used for biomolecule separation. Then, an investigation of the combined sophisticated methods is highlighted. The spotlight also will be shined on the elegance of separation successes in recent years, and the remainder of the article explores how these permit the development of novel techniques.

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Section: Microfluidic‐based Separation Methodsmentioning

confidence: 99%

Molecular Separation by Using Active and Passive Microfluidic chip Designs: A Comprehensive Review

Ebrahimi,

Icoz,

Didarian

et al. 2023

Adv Materials Inter

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show abstract

“…This type of separation covers inertial [24][25][26]/viscoelastic [27][28][29] microfluidics, deterministic lateral displacement (DLD) [30], pinched flow fractionation (PFF) [31], hydrophoresis [32], and hydrodynamic filtration [33]. These methods are simple to use and capable of offering (relatively) high throughput but usually suffer from the drawback of limited resolution and specificity [34].…”

Section: Introductionmentioning

confidence: 99%

Recent advances in multimode microfluidic separation of particles and cells

Song

Xuan

2023

Electrophoresis

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Microfluidic separation of particles and cells is crucial to lab‐on‐a‐chip applications in the fields of science, engineering, and industry. The continuous‐flow separation methods can be classified as active or passive depending on whether the force involved in the process is externally imposed or internally induced. The majority of current separations have been realized using only one of the active or passive methods. Such a single‐mode process is usually limited to one‐parameter separation, which often becomes less effective or even ineffective when dealing with real samples because of their inherent heterogeneity. Integrating two or more separation methods of either type has been demonstrated to offer several advantages like improved specificity, resolution, and throughput. This article reviews the recent advances of such multimode particle and cell separations in microfluidic devices, including the serial‐mode prefocused separation, serial‐mode multistage separation, and parallel‐mode force‐tuned separation.

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“…Microfluidics is a method for manipulating fluids at submillimeter scales that have shown a significant aptitude for advancements in biological research and diagnostics. Due to its quick sample handling and precise fluidic flow control, microfluidic devices have superseded conventional experimental techniques [33][34][35][36][37] , and hence, critical insight is required into the design, manipulation, regulation, and application of MEMS systems to further enhance the field. As a result, a critical understanding of the design, manipulation, regulation, and application of MEMS systems is needed to advance the area.…”

Section: Introductionmentioning

confidence: 99%

A Review on Microchannel Fabrication Methods and Applications in Large-Scale and Prospective Industries

Afzal¹,

Tayyaba²,

Ashraf³

et al. 2022

Evergreen

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Microchannels based on microelectromechanical systems (MEMS) have received a lot of interest in the microfluidics and biomedical fields over the past forty years. While their applications have been multifarious, a comprehensive literature review focusing on their design, type, and applications is not currently present in the literature. Researchers working on these elements of microchannels will gain targeted knowledge from the current review on microchannels. Due to its advanced properties, flexibility of mass, and small size, microdevice demand has been rising quickly, particularly in industrial applications. The classification of microchannels and their uses are the main focus of this work. These include but are not limited to molding, electroplating, lithography, lab-ona-chip, micromolding, micromachining, micromilling, laser ablation, lithography, microcontact printing (µcp), hot embossing, electrochemical micromachining (EMM), and etching. In addition, numerous hybrid techniques for microchannel manufacturing have been reported. So, in essence, this review offers a range of advancements in microchannel manufacturing. The review also attempts to present a qualitative analysis describing the various methodologies associated with microchannels in terms of their design, shape, and flow regimes for applications such as pressure drop and transfer of heat prediction. Additionally, depending on the precise uses needed, a number of materials, including but not limited to ceramics, silicon, metals, and polymers, are utilized in the manufacture of microchannels. On metallic substrates, polymers such as silicon, glass, and polymeric materials are used. The biomedical industry uses polymeric and glass substrates instead of silicon substrates, which are used for mechanical engineering and electronic applications. In addition to outlining methods for choosing the best kind of microchannel, this paper also suggests important directions for the future.

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Geometric structure design of passive label-free microfluidic systems for biological micro-object separation

Cited by 36 publications

References 208 publications

Molecular Separation by Using Active and Passive Microfluidic chip Designs: A Comprehensive Review

Molecular Separation by Using Active and Passive Microfluidic chip Designs: A Comprehensive Review

Recent advances in multimode microfluidic separation of particles and cells

A Review on Microchannel Fabrication Methods and Applications in Large-Scale and Prospective Industries

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