George de Hevesy (1885–1966): discoverer of hafnium, founder of radioanalytical chemistry and X-ray fluorescence analysis and father of nuclear medicine

Niese, S.

doi:10.1007/s10967-016-4922-2

Cited by 3 publications

(7 citation statements)

References 15 publications

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“…They found that the specific radioactivity on the anode was diluted from the original by the natural lead present in the sample. By correcting for this, the amount of nonradioactive lead could be determined, and a new method of analytical chemistry was invented. , …”

Section: Theory Of Idamentioning

confidence: 99%

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Hands-On Model of the Principle of Isotope Dilution Analysis for Use in an Interactive Teaching and Learning Classroom Exercise

Holgersson

2021

J. Chem. Educ.

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A simple hands-on model for illustrating the concept of isotope dilution analysis (IDA) has been devised. The model consists of two sets of beads of different sizes, with one set representing atoms of the analyte and the other set representing solvent water molecules. Phase separation is mimicked by sieving the beads, and the results are detected according to the color of the analyte beads. In this paper, the following three IDA methods are illustrated using the model: (1) direct IDA, (2) substoichiometric IDA, and (3) IDA-assisted neutron activation analysis. The model was demonstrated for a small group of graduate students with previous knowledge of nuclear chemistry, and the response from an inquiry held after the demonstration was good. It is suggested that the model can be used in a dry chemistry laboratory exercise to demonstrate the methodological differences between the different IDA methods, without the need for costly radioisotopes or irradiation facilities. It can also be used as a tool for engaging students in meta-modeling activities.

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Section: Theory Of Idamentioning

confidence: 99%

“…Later, Hevesys’ interest was directed toward medical applications of the IDA method. In 1944, Hevesy received the Nobel prize in Chemistry for 1943 for his discoveries of radioanalytical methods and essentially founding the field of nuclear medicine …”

Section: Theory Of Idamentioning

confidence: 99%

Hands-On Model of the Principle of Isotope Dilution Analysis for Use in an Interactive Teaching and Learning Classroom Exercise

Holgersson

2021

J. Chem. Educ.

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“…2) The concept of radioindicator tracer chemistry was born through a talk with Ernest Rutherford. 3) He encouraged Hevesy to separate the natural radioisotope of lead-210 ( 210 Pb) from its admixture with large amounts of nonradioactive lead stored at that time in Rutherford's laboratory. Hevesy used chemical methods for such separation.…”

Section: Introductionmentioning

confidence: 99%

“…Hevesy studied the transfer of lead from soil in different parts of bean plants using 210 Pb, which was the first application of the radioactive tracer technique to biology. 3) The extreme sensitivity of physical radioassay methods allowed him to carry out these experiments with such minuscule concentrations of lead so as to avoid its toxic properties. In 1935 Hevesy investigated the distribution and kinetics of the exchange of phosphorus in different parts of animals using the 32 P radioisotope, which was the first radioindicator study in life sciences.…”

Section: Introductionmentioning

confidence: 99%

“…In 1935 Hevesy investigated the distribution and kinetics of the exchange of phosphorus in different parts of animals using the 32 P radioisotope, which was the first radioindicator study in life sciences. 3) The essence of the radioindicator tracer method is that radioactivity is of such minute quantities that it will not cause any toxic affect on the system, and can be detected with high sensitivity by discriminat-ing any conceivable background events as low as possible. A radiolabeled tracer allows noninvasive measurements of the distribution and function in a biological system.…”

Section: Introductionmentioning

confidence: 99%

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Production scheme for diagnostic-therapeutic radioisotopes by accelerator neutrons

Nagai

2021

Proceedings of the Japan Academy. Ser. B: Physical and Biologic

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Interest has been growing in the development of medical radioisotopes used for noninvasive nuclear medicine imaging of disease and cancer therapy. Especially the development of an alternative production scheme of 99 Mo, the mother radioisotope of 99m Tc used for imaging, is required, because the current supply chain of the reactor product 99 Mo is fragile worldwide. We have proposed a new production scheme of 99 Mo as well as therapeutic radioisotopes, such as 64 Cu and 67 Cu, using accelerator neutrons provided by the nat C(d,n) reaction. Based on this scheme we have obtained high-quality 99m Tc, 64 Cu, and 67 Cu suitable for clinical use by developing both production and separation methods of the radioisotopes. We proposed a new facility to constantly and reliably produce a wide variety of high-quality, carrier-free radioisotopes, including 99 Mo, with accelerator neutrons. We report on the development of the proposed scheme and future prospects of the facility toward the domestic production of medical radioisotopes.

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Alternative approach to study chemical processes for the preparation of 10Be and 26Al targets for AMS

Kameník

Kučera

Garba

2023

Nuclear Instruments and Methods in Physics Research Section B:

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George de Hevesy (1885–1966): discoverer of hafnium, founder of radioanalytical chemistry and X-ray fluorescence analysis and father of nuclear medicine

Cited by 3 publications

References 15 publications

Hands-On Model of the Principle of Isotope Dilution Analysis for Use in an Interactive Teaching and Learning Classroom Exercise

Hands-On Model of the Principle of Isotope Dilution Analysis for Use in an Interactive Teaching and Learning Classroom Exercise

Production scheme for diagnostic-therapeutic radioisotopes by accelerator neutrons

Alternative approach to study chemical processes for the preparation of 10Be and 26Al targets for AMS

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