The data article presents a dataset suitable to measure regional Industry 4.0 (I4.0+) readiness. The I4.0+ dataset includes 101 indicators with 248 958 observations, aggregated to NUTS 2 statistical level) based on open data in the field of education (ETER, Erasmus), science (USPTO, MA-Graph, GRID), government (Eurostat) and media coverage (GDELT). Indicators consider the I4.0-specific domain of higher education and lifelong learning, innovation, technological investment, labour market and technological readiness as indicators. A composite indicator, the I4.0+ index was constructed by the Promethee method, to identify regional rank regarding their I4.0 performance. The index is validated with economic (GDP) and innovation indexes (Regional Innovation Index).