Geraniol attenuates oxidative stress by Nrf2 activation in diet-induced experimental atherosclerosis

Jayachandran, Muthukumaran; Chandrasekaran, Balaji; Nalini, Namasivayam

doi:10.1515/jbcpp-2014-0057

Cited by 35 publications

(16 citation statements)

References 43 publications

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“…The obtained results have revealed that the terpene elevated Nrf2 protein translocation from cytoplasm to the nucleus, leading to antioxidant and anti‐inflammatory effects . Another monoterpene, geraniol, was studied due to its demonstrated ability to preserve in hamsters, plasma lipid status, endothelial function and antioxidant status, as well as to inhibit lipid peroxidation . The study concluded that the positive influence of geraniol on changes resulted from it influencing oxidative stress are connected with activating Nrf2 as the main antioxidant transcriptional factor.…”

Section: Antioxidant Activity Of Common Terpenoidsmentioning

confidence: 99%

Natural Monoterpenes: Much More than Only a Scent

Wojtunik-Kulesza

Kasprzak

Oniszczuk

et al. 2019

Chemistry & Biodiversity

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Terpenes are a widespread group of secondary metabolites that can be found in various family plants such as the Lamiaceae. In view of their numerous valuable biological activities, the industrial production of concrete terpenes and essential oils rich in the substances is intensively studied. Monoterpenes constitute a significant part of the whole group of the aforementioned secondary metabolites. This is due to their numerous biological activities and their ability to permeate the skin. Despite the fact that these substances have gain popularity, they are not comprehensively characterized. The presented review is based on studies of the biological activities of the most important monoterpenes and the essential oils rich in these compounds. The authors focused attention on antioxidant activity, inhibition towards acetyl-and butyrylcholinesterase, and α-amylase and α-glucosidase, antifungal, hepatoprotective, sedative properties, and their skin permeation enhancement.

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Section: Antioxidant Activity Of Common Terpenoidsmentioning

confidence: 99%

Natural Monoterpenes: Much More than Only a Scent

Wojtunik-Kulesza

Kasprzak

Oniszczuk

et al. 2019

Chemistry & Biodiversity

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“…Anti-proliferation Apoptosis, DNA damage, and cell cycle arrest In vitro [10] Endometrial carcinoma Anti-migration Antiangiogenesis In vitro and in vivo [15] Liver cancer Anti-proliferation Apoptosis In vitro and in vivo [17][18][19] Lung cancer Anti-proliferation Apoptosis In vitro [21] Pancreatic cancer Anti-proliferation Apoptosis In vitro [26] Prostate cancer Anti-proliferation Cell cycle arrest In vitro [28] Skin cancer Anti-proliferation Apoptosis In vivo [30] 100 mg/kg GE showed that the underlying mechanism consists of alleviating the change in the lipid profile and endothelial function marker, promoting antioxidant enzyme activities and abating alterations in the LPO markers and Nrf2 expression. Histologically, GE negatively affected oxidative stress by increasing the activity of Nrf2 [35]. In the meantime, GE could exert anti-inflammatory and antioxidant effects.…”

Section: Colon Cancermentioning

confidence: 96%

Pharmacological Properties of Geraniol – A Review

et al. 2018

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Geraniol is an acyclic isoprenoid monoterpene isolated from the essential oils of aromatic plants including Cinnamomum tenuipilum, Valeriana officinalis, and several other plants. The limited source of geraniol from plant isolation cannot fulfill the great demand from the flavor and fragrance industries, which require maximizing geraniol production through biotechnology processes. The diverse activities of geraniol suggested that geraniol could treat various diseases as a promising drug candidate. In order to evaluate the potential of geraniol applied in a clinical trial, this review aims at providing a comprehensive summary of the pharmacological effects of geraniol. The publications retrieved from PubMed, ScienceDirect, Springer, and Wiley databases were collected and summarized for the last 6 years. Then, the potential application of geraniol as a drug is discussed based on its pharmacological properties, including antitumor, anti-inflammatory, antioxidative, and antimicrobial activities, and hepatoprotective, cardioprotective, and neuroprotective effects. Hence, this review aims at providing evidence of the pharmacological activities of geraniol in the context of further development as a drug candidate in clinical application.

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“…In addition, studies also reported a significant development of the disease for other hamster strain, with a range of cholesterol from 0.1-1.0% and the period of dietary intervention as early as two weeks up to 40 weeks (Ahmed 2009;Chen et al 2014;Cherng & Shih 2005;Huang et al 2015;Ioriya et al 2002;Jayachandran et al 2015Jayachandran et al , 2015Kanashiro et al 2007;Krause et al 1992;Lin et al 2013;Lin et al 2012;Mawatari et al 2004;Romain et al 2014;Romain et al 2012;Singh et al 2013;Singh et al 2015;Uehara et al 2002;Vide et al 2015;Zha et al 2009).…”

Section: The Role Of High Fat High Cholesterol (Hfhc) Diet In the Devmentioning

confidence: 98%

Coconut Oil and Cholesterol as Challenge Agents to Induce Hyperlipidemia and Atherosclerosis in Hamster Animal Model

Naina-Mohamed¹

2018

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ABSTRAKHiperlipiedmia adalah keadaan paras lipid tinggi dalam plasma dan sering dikaitkan dengan pemendapan titisan lipid dalam aorta yang menyebabkan kejadian aterosklerosis. Aterosklerosis adalah penyakit kardiovaskular yang bermula dengan pembentukan sel-sel busa di dalam dinding vascular, seterusnya menyebabkan aliran darah bergelora, kecederaan pada lapisan endotelial dan trombosis pada pembuluh darah. Sejak awal 1980-an, hamster Golden-Syrian telah digunakan secara meluas sebagai model haiwan dalam penyelidikan hiperlipiedmia dan aterosklerosis. Penggunaan hamster sebagai model hiperlipiedmia dan aterosklerosis adalah kerana profil lipoprotein mereka yang lebih dekat dengan penetapan manusia, sensitif terhadap diet tinggi-lemak tinggi-kolesterol (TLTK) dan model roden yang sesuai. Aterosklerosis boleh dicetus ke atas hamster melalui cabaran diet TLTK. Selama beberapa dekad, minyak kelapa (MK) biasa digunakan sebagai sumber lemak dalam reka bentuk diet berkomposisi asid lemak tepu tinggi (ALT). Dalam ulasan ini, kami merumuskan literatur yang diterbitkan dengan reka bentuk yang melibatkan MK-dan kolesterol-cetusan hiperlipidmia, aterosklerosis atau kedua-duanya. Faktor-faktor yang mungkin mempengaruhi kebolehan campuran MK dan kolesterol untuk menggalakkan hiperlipiedmia seperti tempoh diet, jenis hamster dan jumlah pemakanan akan dinilai dan diringkaskan. ABSTRACTHyperlipidemia is a condition of high lipid levels in the plasma and often linked with the deposition of lipid droplets in the aorta which initiate the progression of atherosclerosis. Atherosclerosis is a common cardiovascular disorder initiated by the formation of foams cells in the vascular wall which leads to turbulent blood flow, injury to the endothelial layer and subsequent vascular thrombosis. Since the early 1980's, Golden-Syrian hamsters have been widely used as an animal model in the research of hyperlipidemia and atherosclerosis. The use of hamsters in the hyperlipidemic and atherosclerotic model is due to their lipoprotein profile that is closer to human setting, sensitive to high-fat high-cholesterol (HFHC) diet and a suitable rodent model. Atherosclerosis can be induced in hamsters through dietary challenge with HFHC diet. Over the decades, coconut oil (CNO) was commonly used as the source of fat in the diet design of high saturated fatty acids (SFA) composition. In this review, we summarized published literature with designs involving CNO plus cholesterol-induced hyperlipidemia, atherosclerosis or both. The factors that may influence the ability of CNO and cholesterol combination to induce hyperlipidemia such as the period of dietary intervention, hamster strains and the dietary amount were evaluated and summarized.

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Geraniol attenuates oxidative stress by Nrf2 activation in diet-induced experimental atherosclerosis

Abstract: Supplementation with GOH appreciably prevented the alterations induced by the AD on all the above parameters. Thus, GOH offers marked protection against AD-induced abnormalities.

Cited by 35 publications

References 43 publications

Natural Monoterpenes: Much More than Only a Scent

Natural Monoterpenes: Much More than Only a Scent

Pharmacological Properties of Geraniol – A Review

Coconut Oil and Cholesterol as Challenge Agents to Induce Hyperlipidemia and Atherosclerosis in Hamster Animal Model

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