Geranylated Flavanones from &lt;i&gt;Paulownia coreana&lt;/i&gt; and Their Inhibitory Effects on Nitric Oxide Production

Jin, Qinghao; Lee, Chul; Lee, Jin Woo; Lee, Dong‐Ho; Kim, Youngsoo; Hong, Jin Tae; Kim, Jin Sook; Kim, Joo Hwan; Lee, Mi Kyeong; Hwang, Bang Yeon

doi:10.1248/cpb.c14-00839

Cited by 12 publications

(3 citation statements)

References 21 publications

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“…Its effects are even better than those of indomethacin, which has been used as a positive control [ 165 ]. It inhibits the production of NO in LPS-stimulated macrophages [ 173 ], and two independent studies showed that diplacone affects the expression of COX-2 [ 167 ] and its activity. Moreover, it was found to be a potent 5-LOX inhibitor [ 168 ].…”

Section: Discussionmentioning

confidence: 99%

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Prenylated Flavonoids in Topical Infections and Wound Healing

et al. 2022

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The review presents prenylated flavonoids as potential therapeutic agents for the treatment of topical skin infections and wounds, as they can restore the balance in the wound microenvironment. A thorough two-stage search of scientific papers published between 2000 and 2022 was conducted, with independent assessment of results by two reviewers. The main criteria were an MIC (minimum inhibitory concentration) of up to 32 µg/mL, a microdilution/macrodilution broth method according to CLSI (Clinical and Laboratory Standards Institute) or EUCAST (European Committee on Antimicrobial Susceptibility Testing), pathogens responsible for skin infections, and additional antioxidant, anti-inflammatory, and low cytotoxic effects. A total of 127 structurally diverse flavonoids showed promising antimicrobial activity against pathogens affecting wound healing, predominantly Staphylococcus aureus strains, but only artocarpin, diplacone, isobavachalcone, licochalcone A, sophoraflavanone G, and xanthohumol showed multiple activity, including antimicrobial, antioxidant, and anti-inflammatory along with low cytotoxicity important for wound healing. Although prenylated flavonoids appear to be promising in wound therapy of humans, and also animals, their activity was measured only in vitro and in vivo. Future studies are, therefore, needed to establish rational dosing according to MIC and MBC (minimum bactericidal concentration) values, test potential toxicity to human cells, measure healing kinetics, and consider formulation in smart drug release systems and/or delivery technologies to increase their bioavailability.

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Section: Discussionmentioning

confidence: 99%

“…IC 50 = 7.2 µM in THP-1 cells [232]. Inhibition of LPS-induced NO production in RAW 264.7 cells, IC 50 = 5.9 µM [173].…”

Section: -O-methyldiplacolmentioning

confidence: 99%

Prenylated Flavonoids in Topical Infections and Wound Healing

et al. 2022

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“…Epidemiological studies revealed that an increased daily intake of phenolic compounds in dietary supplements act as anti-oxidant and anti-inflammatory agents to increase thermogenesis and energy expenditure while decreasing inflammation and oxidative stress, further supporting progress towards decreased metabolic disorders [ 1 , 5 ]. Previous studies confirmed that the species of the genus Paulownia (belonging to the family scrophulariaceae) exhibited a broad spectrum of biological effects, including antioxidant, anticarcinogenic [ 6 , 7 ], antiphlogistic [ 8 ], antiviral [ 9 ], antimicrobial [ 10 ] and anti-cholinesterase activities [ 11 ]. Paulownia fortunei (Seem.)…”

Section: Introductionmentioning

confidence: 99%

Flavonoid-Rich Extract of Paulownia fortunei Flowers Attenuates Diet-Induced Hyperlipidemia, Hepatic Steatosis and Insulin Resistance in Obesity Mice by AMPK Pathway

Liu

Sun

et al. 2017

Nutrients

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The flavonoid-rich extract from Paulownia fortunei flowers (EPF) has been reported to prevent obesity and other lipid metabolism disease. However, the mechanism of its protective effects is not yet clear. The objective of this study was to investigate molecular factors involved in the hypoglycemic and hypolipidemic effects of EPF in obese mice fed a high-fat diet (HFD). Male h ICR (Institute of Cancer Research) mice were fed a HFD containing or not containing the EPF (50 or 100 mg/kg) for eight weeks. EPF reduced body weight gain, lipid accumulation in livers and levels of lipid, glucose and insulin in plasma as well as reduced insulin resistance as compared with the HFD group. EPF significantly decreased serum aminotransferase activity of the HFD group. We observed that EPF administration significantly increased the level of AMP-activated kinase (AMPK) phosphorylation and prevented fat deposits in livers and HepG2 cells, but these effects were blocked by compound C (an AMPK inhibitor). The protective effects of EPF were probably associated with the decrease in HMGCR, SREBP-1c and FAS expressions and the increase in CPT1 and phosphor-IRS-1 expressions. Our results suggest that EPF might be a potential natural candidate for the treatment and/or prevention of overweight and hepatic and metabolic-related alterations induced by HFD.

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Lignans from the Twigs of Euonymus alatus (Thunb.) Siebold and Their Biological Evaluation

Lee

Moon²,

Choi

et al. 2016

Chemistry & Biodiversity

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A new sesquilignan, euonymolin A (1), and six known lignans, (-)-de-O-methylmagnolin (2), (+)-de-O-methylepimagnolin A (3), (+)-syringaresinol (4), (+)-pinoresinol (5), (+)-medioresinol (6), and (+)-lariciresinol 4'-O-β-d-glucopyranoside (7), were isolated from the twigs of Euonymus alatus (Thunb.) Siebold (Celastraceae). The structures of the isolated compounds were elucidated based on spectroscopic analyses, including extensive 1D- and 2D-NMR techniques, HR-MS analysis and circular dichroism (CD) data, and the literature data. All of the isolated compounds were evaluated for antiproliferative activity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines and inhibition of nitric oxide (NO) production in a lipopolysaccharide (LPS)-activated BV2 cell line. All compounds showed cytotoxicity against the SK-MEL-2 cell line with IC values of 23.24 - 48.14 μm and inhibited NO production in LPS-activated BV-2 cells with IC values of 6.75 - 23.53 μm.

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Geranylated Flavanones from <i>Paulownia coreana</i> and Their Inhibitory Effects on Nitric Oxide Production

Cited by 12 publications

References 21 publications

Prenylated Flavonoids in Topical Infections and Wound Healing

Prenylated Flavonoids in Topical Infections and Wound Healing

Flavonoid-Rich Extract of Paulownia fortunei Flowers Attenuates Diet-Induced Hyperlipidemia, Hepatic Steatosis and Insulin Resistance in Obesity Mice by AMPK Pathway

Lignans from the Twigs of Euonymus alatus (Thunb.) Siebold and Their Biological Evaluation

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