Germ cell cancer and dermatomyositis

Clayton, Amy; Mead, G. M.

doi:10.1016/s0936-6555(98)80118-0

Cited by 9 publications

(4 citation statements)

References 19 publications

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“…reported that 198 of 618 cases with dermatomyositis had cancer, and of those 198 cases, 115 developed cancer after diagnosis of dermatomyositis, particularly lung, pancreatic, stomach, colorectal, and ovarian cancers, and non-Hodgkin lymphoma. 1 Testicular cancer associated with dermatomyositis, however, seems to be rare and to our knowledge, the present case is only the eighth reported [3][4][5][6][7][8] in which the symptoms of dermatomyositis improved spontaneously with regression of testicular cancer after high orchidectomy and chemotherapy. This case illustrates the importance of the palpation of testes in young male patients with dermatomyositis.…”

Section: ① ② ➂mentioning

confidence: 78%

Successful cure of dermatomyositis after treatment of nonseminomatous testicular cancer

et al. 2005

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Although the association between dermatomyositis and cancer is well recognized, there have been a limited number of reports of dermatomyositis associated with testicular cancer. We report the case of a 31-year-old man who was diagnosed with dermatomyositis. Because the patient's serum levels of a-fetoprotein and human chorionic gonadotropin beta subunit were elevated, the patient was referred to our department. Physical examination revealed an induration (2 cm ¥ 2 cm) in the left testis and the patient was diagnosed with stage IIIB left testicular cancer. A left high orchidectomy was then performed, and pathological examination revealed embryonal carcinoma. The patient was started on a systemic chemotherapeutic (etoposide, ifosfamide and cisplatin; VIP) regimen. After the third chemotherapy session, metastases had completely disappeared, the serum levels of afetoprotein and human chorionic gonadotropin beta subunit had normalized and the dermatomyositis symptoms had improved. Cancer is known to be a trigger of dermatomyositis. This case illustrates the importance of palpation of the testes in young patients with dermatomyositis.

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Section: ① ② ➂mentioning

confidence: 78%

Successful cure of dermatomyositis after treatment of nonseminomatous testicular cancer

et al. 2005

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“…Five patients affected with dermatomyositis and germ cell cancer have been reported [4][5][6][7]. Four had primitive neoplasms of the testis that were proved histologically to be teratomas [5][6][7]. Only 1 patient had germinal cancer with primary localization in the mediastinum [4].…”

mentioning

confidence: 99%

Dermatomyositis and Retroperitoneal Germ Cell Cancer

et al. 2001

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“…Many other associated tumors have been reported, including cancer of the pancreas, thymoma, germ-cell tumors, melanoma, nasopharyngeal cancer, and lymphoma. 2,8,34,123,210,212 An association with cancer has not been demonstrated in childhood dermatomyositis.…”

Section: Paraneoplastic Disorders Of Neuromuscular Junction and Musclementioning

confidence: 99%

Paraneoplastic syndromes of the spinal cord, nerve, and muscle

Rudnicki

Dalmau

2000

Muscle Nerve

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Cancer can affect the peripheral nervous system by nonmetastatic, sometimes immune-mediated mechanisms. Recognition of these paraneoplastic syndromes is important because it can lead to the detection of the tumor, and also helps to avoid unnecessary studies to determine the cause of the neurologic symptoms in patients with cancer. Many paraneoplastic syndromes of the peripheral nervous system are not associated with serum antibodies that serve as markers of paraneoplasia. For this group of disorders the diagnosis depends on the clinician's index of suspicion and conventional electrophysiologic and laboratory tests. Treatment of the tumor, immunotherapy, or both may improve some of these syndromes. This review focuses on paraneoplastic syndromes of the spinal cord, peripheral nerve, and muscle.

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Germ cell cancer and dermatomyositis

Cited by 9 publications

References 19 publications

Successful cure of dermatomyositis after treatment of nonseminomatous testicular cancer

Successful cure of dermatomyositis after treatment of nonseminomatous testicular cancer

Dermatomyositis and Retroperitoneal Germ Cell Cancer

Paraneoplastic syndromes of the spinal cord, nerve, and muscle

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