Germline mutation rates in mice following in utero exposure to diesel exhaust particles by maternal inhalation

Ritz, Caitlin; Ruminski, Wojciech; Hougaard, Karin Sørig; Wallin, Håkan; Vogel, Ulla; Yauk, Carole L.

doi:10.1016/j.mrfmmm.2011.04.007

Cited by 35 publications

(33 citation statements)

References 28 publications

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“…In contrast, male offspring whose mothers inhaled the diesel exhaust particle of NIST2975 displayed increased microsatellite instability, indicating that the effect was induced in utero. The effect of the prenatal exposure to DEP was permanent, as microsatellite instability were present in the adult offspring months after exposure was terminated [152]. The susceptibility of male germ cells to insult by particle exposure is supported by studies in adult mice.…”

Section: Genotoxicity and Mutations In Somatic And Germline Tissuesmentioning

confidence: 92%

“…This might also be the case when exposure takes place during fetal life. Indeed, microsatellites of the female germline cells were unaffected following maternal gestational airway exposure in the studies of TiO 2 and carbon black NP in the studies described in more detail above, as well as after maternal inhalation of standard material diesel exhaust particle NIST2975 (which contains low levels of PAHs) [149,151,152]. In contrast, male offspring whose mothers inhaled the diesel exhaust particle of NIST2975 displayed increased microsatellite instability, indicating that the effect was induced in utero.…”

Section: Genotoxicity and Mutations In Somatic And Germline Tissuesmentioning

confidence: 98%

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A perspective on the developmental toxicity of inhaled nanoparticles

Hougaard

Campagnolo

Chavatte‐Palmer

et al. 2015

Reproductive Toxicology

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158

126

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This paper aimed to clarify whether maternal inhalation of engineered nanoparticles (NP) may constitute a hazard to pregnancy and fetal development, primarily based on experimental animal studies of NP and air pollution particles. Overall, it is plausible that NP may translocate from the respiratory tract to the placenta and fetus, but also that adverse effects may occur secondarily to maternal inflammatory responses. The limited database describes several organ systems in the offspring to be potentially sensitive to maternal inhalation of particles, but large uncertainties exist about the implications for embryo-fetal development and health later in life. Clearly, the potential for hazard remains to be characterized. Considering the increased production and application of nanomaterials and related consumer products a testing strategy for NP should be established. Due to large gaps in data, significant amounts of groundwork are warranted for a testing strategy to be established on a sound scientific basis.

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Section: Genotoxicity and Mutations In Somatic And Germline Tissuesmentioning

confidence: 92%

Section: Genotoxicity and Mutations In Somatic And Germline Tissuesmentioning

confidence: 98%

A perspective on the developmental toxicity of inhaled nanoparticles

Hougaard

Campagnolo

Chavatte‐Palmer

et al. 2015

Reproductive Toxicology

Self Cite

158

126

View full text Add to dashboard Cite

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“…Daily sperm production (DSP) decreased in male rodents whose mothers inhaled diesel exhaust particles (DEP) or whole diesel exhaust during pregnancy [ 28 -30 ]. Furthermore, maternal exposure to DEP increased the number of germline mutations in male offspring, and these mutations were transferred to the next generation in mice [ 31 ]. Observations of adverse effects on male reproductive function following prenatal exposure to particles with few associated compounds, as described above for TiO 2 and CB, indicate that prenatal exposure to particulates per se poses a threat to male reproductive function.…”

Section: Introductionmentioning

confidence: 89%

Transgenerational Effects of NMs

Poma

Colafarina

Fontecchio

et al. 2014

Advances in Experimental Medicine and Biology

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Nanomaterials are present in a number of commercially available products but there are uncertainties as to whether the unique properties that support their commercial use may also pose potential health risks. Information is missing concerning the influence of nanomaterials on the overall reproductive outcome and transgenerational effects in animals and plants. To obtain this information, long-term studies would be required using animal models phylogenetically close to humans and exposure conditions that reflect realistic scenarios with regard to dosages and admission. The nanoreprotoxicology literature published to date is largely descriptive in nature regarding the effects of nanoparticles. The mechanisms, which determine particle reproduction compatibility, are mostly elusive at the moment. Thus, it is recommended that future research explore the interactions between nanomaterials and transgenerational matter on a molecular level. It would, for instance, be of major importance to understand the behaviour of nanoparticles inside the cells but also their genotoxic and epigenetic effects. Recent studies have shown that intravenous and/or intra-abdominal administration of nanoparticles to mice results in their accumulation in the cells of many tissues, including the brain and the testis, suggesting that they easily pass through the blood-brain and blood-testis barriers. In parallel embryo development after exposure to nanoparticles should be comparatively investigated. The majority of studies on embryo toxicology have concentrated on piscine embryos, mostly derived from zebrafish. Plants for human food as an important component of the ecosystem need also to be taken into account when evaluating transgenerational effects of engineered nanomaterials in crops.

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“…Chez l'homme, l'exposition aux particules PM 10 et au dioxyde d'azote a été associée à des variations du poids du placenta ou du ratio foeto-placentaire [52]. L'exposition in utero de souris mâles à des particules de diesel provoque des taux de mutations (touchant les expanded simple tandem repeat (ESTR) DNA loci 5 ) plus élevés par rapport aux souris non exposées [53] et altère la qualité du sperme chez l'adulte [54]. 5 Locus très informatifs pour l'analyse de mutations de lignées germinales spontanées et induites.…”

Section: La Pollution Atmosphériqueunclassified