Geruchsstoffmetabolismus im Menschen

Kornbausch, Nicole; Debong, Marcel W.; Buettner, Andrea; Heydel, Jean‐Marie; Loos, Helene M.

doi:10.1002/ange.202202866

Cited by 2 publications

(1 citation statement)

References 119 publications

(279 reference statements)

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“…Concerning metabolization events, studies to date have pointed to the role of nasal XME (also called OME for odorant-metabolizing enzymes) in the protection of the olfactory neuroepithelium as well as in the biotransformation of odorants. XME are present in the olfactory epithelium and the nasal mucus (Kornbausch et al, 2022). They are classed as phase I (activation of the odorant mainly through oxidation), phase II (functionalization through transfer of polar groups such as glutathione or UDP-glucuronic acid, not necessarily consecutive of phase I) and phase III (excretion of the metabolite out of the epithelium to the mucus when the previous phase occurs within the cell) enzymes.…”

Section: Peripheral Mechanisms Impacting Aroma Molecules In the Nasal...mentioning

confidence: 99%

The role of perireceptor events in flavor perception

Boichot

Muradova²,

Nivet³

et al. 2022

Front. Food. Sci. Technol.

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The sensory perception of food is a complex phenomenon involving the integration of different stimuli (aroma, taste, trigeminal sensations, texture and visual). Flavor compounds activate odorant, taste and trigeminal chemoreceptors, generating a depolarization of the sensory neurons and then the consciousness of food flavor perception. Recent studies are increasingly highlighting the importance of perireceptor events, which include all the molecular events surrounding the receptors, in the modulation of flavor perception. These events affect the quantity and quality of flavor compounds in the environment of chemoreceptors. They include the metabolization of flavor compounds by enzymes present in biological fluids (saliva and mucus) and the oronasal epithelia and noncovalent interactions with binding proteins. Perireceptor mechanisms have been extensively studied in insects and mammals, demonstrating the importance of the entailed processes in the termination of the chemical signal. In humans, research is in full swing. Here, we reviewed the perireceptor mechanisms recently reported in vitro, in biological fluids and in cells and in vivo in humans. These studies indicate that perireceptor mechanisms likely have an important contribution to flavor perception. This mini-review focuses on recent pioneering studies that are paving the way for this new research area. It also suggests that new approaches taking into account the real conditions of food consumption will be required in the future to accurately address this question.

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Section: Peripheral Mechanisms Impacting Aroma Molecules In the Nasal...mentioning

confidence: 99%

The role of perireceptor events in flavor perception

Boichot

Muradova²,

Nivet³

et al. 2022

Front. Food. Sci. Technol.

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Deciphering anthropogenic and biogenic contributions to selected non-methane volatile organic compound emissions in an urban area

Peron,

Graus,

Striednig

et al. 2024

Atmos. Chem. Phys.

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Abstract. The anthropogenic and biogenic contributions of isoprene, monoterpenes, sesquiterpenes and methanol in an urban area were estimated based on direct eddy covariance flux observations during four campaigns between 2018 and 2021. While these compounds are typically thought to be dominated by biogenic sources on regional and global scales, the role of potentially significant anthropogenic emissions in urban areas has been recently debated. Typical fluxes of isoprene, monoterpenes and sesquiterpenes were on the order of 0.07 ± 0.02, 0.09 and 0.003 nmol m−2 s−1 during spring. During summer, emission fluxes of isoprene, monoterpenes and sesquiterpenes were higher on the order of 0.85 ± 0.09, 0.11 and 0.004 nmol m−2 s−1. It was found that the contribution of the anthropogenic part is strongly seasonally dependent. For isoprene, the anthropogenic fraction can be as high as 64 % in spring but is typically very low < 18 % during the summer season. For monoterpenes, the anthropogenic fraction was estimated to be between 43 % in spring and less than 20 % in summer. With values of 2.8 nmol m−2 s−1 in spring and 3.2 nmol m−2 s−1 in summer, methanol did not exhibit a significant seasonal variation of observed surface fluxes. However, there was a difference in emissions between weekdays and weekends (about 2.3 times higher on weekdays in spring). This suggests that methanol emissions are likely influenced by anthropogenic activities during all seasons.

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Geruchsstoffmetabolismus im Menschen

Cited by 2 publications

References 119 publications

The role of perireceptor events in flavor perception

The role of perireceptor events in flavor perception

Deciphering anthropogenic and biogenic contributions to selected non-methane volatile organic compound emissions in an urban area

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