Gesamtthyroxin im Serum

Herrmann, Jens; Brasé, Ariadna; Marées, H. de; Krüskemper, H. L.

doi:10.1515/cclm.1970.8.6.605

Cited by 4 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Routine methods included the measurement of fasting cholesterol, the triiodothyronine Sephadex uptake (Thyopac-3, Radiochemical Centre, Amenham), the estimation of serum thyroxine (T,) (modification of the competitive protein binding analysis [4], and the computation of the free thyroxine index (FI',-Index) from the results of the two latter procedures (division of T, by T, Sephdex uptake). According to the results of these techniques the ptients were alotted to different biochemically classified groups of hypothyroidism.…”

Section: Methodsmentioning

confidence: 99%

Classification of Hypothyroidism in Evaluating Patients after Radioiodine Therapy by Serum Cholesterol, T₃‐Uptake. Total T₄, FT₄‐Index, Total T₃, Basal TSH and TRH‐Test*

Wenzel

Meinhold

Raffenberg

et al. 1974

Eur J Clin Investigation

View full text Add to dashboard Cite

During a follow-up examination of patienta after radioiodine therapy for thyrotoxicosis, 128 patienta without recurrent hyperthyroidism were investigated for the clarification of different degrees of hypothyroidism. The clinical diagnosis and the conventional testa for circulating thyroid hormones were compared to the estimation of serum thyroid stimulating hormone (TSH), and to the thyrotropin-relensing hormono (TRH) test, which was performed with 6Wpg synthetic TRH I.V., and referred to age 8nd sex specific normal ranges. Moreover, serum triiodothpnine (T,) WDB estimated by radioimmunoaasay. Rasulta: 1. A gradual claasification of biochemical groupdifferences gave more significant discrimination than a division into group based on clinical impression. Different grades of severity of hypothyroidism could be demonstrated by highly significant differences of free thyroxine index (FT,-Index) between the 1st grou of patienta with low IT,-Index and a 2nd group with ramxf basal TSH (and normal F&-Index), between the 2nd group and a 3rd group with an elevated value of A TSH,, (and normal FT,-Index and basal TSH), and between the 3rd p u p and a 4th group of biochemically normal reacting patienta and controls. There was a less significant difference with very considerable overlap between clinically established groups. 2. T,-uptake, total T, and FT,-Index are not sufficient for detecting hypothyroidism in individual patienta, although their group-differences are significant in biochemical classification. 3. Neither between clinical nor between biochemical u p was there any significant correlation with serum chof%xol. 4. Triiodothyronine can be normal or elevated in a situation with low T4 and raised TSH concentrations. Conclusions: Evidence could be given that hypothyroidism is a graded phenomenon. Ita classification by biochemical data is more reaeonable than a clinic31 division. Advancing severity of hypothyroidism after radiation therapy ie compensated during a certain nod by supplementary production of triiodothyronine. As t r p i d hormone concentration in pirtienta with pathological Berum TSH or TRH-test is significantly lower than in euthyroid patients or in controls, replacement therapy in early stages of hypothyroidism also seems reasonable.

show abstract

Section: Methodsmentioning

confidence: 99%

Classification of Hypothyroidism in Evaluating Patients after Radioiodine Therapy by Serum Cholesterol, T₃‐Uptake. Total T₄, FT₄‐Index, Total T₃, Basal TSH and TRH‐Test*

Wenzel

Meinhold

Raffenberg

et al. 1974

Eur J Clin Investigation

View full text Add to dashboard Cite

show abstract

“…Das Thyroxin im Serum wurde nach der Vorschrift von MURPHY und PATTEE in der Modifikation nach SIERSBAEK-NDELSEN (5) unter Verwendung von Dowex 1X8 200-400 mesh als Ionenaustauscher bestimmt (4). Das radioaktive 125 J-Thyroxin wurde vom Radiochemical Center, Amersham, bezogen.…”

Section: Materials Und Methodenunclassified

Zur Methodik der Bestimmung der ETR (Effective Thyroxine Ratio)

Rudorff¹,

Herrmann²,

Krüskemper³

1973

Clinical Chemistry and Laboratory Medicine

Self Cite

View full text Add to dashboard Cite

Determination of the Effective Thyroxin Ratio (ETR)The Effective Thyroxine Ratio (ETR) was investigated as an assessment of thyroid function. The concentration of thyroxine in the test serum is measured in the presence of thyroxine-binding proteins of the same test serum. ETR is calculated as the ratio of the concentrations of thyroxine in the test serum and in normal pool serum. From measurements in patients with normal thyroid function (i. e. normal subjects, pregnant women, women on oral contraceptives and patients with acute hepatitis) and in patients with either hyper-oder hypothyroidism ETR has proven to be a valid parameter for the assessment of thyroid function. Advantages of this method are its independence from the concentration of thyroxine binding protein, its simplicity and rapidity, and its low costs.Die beiden zur Zeit gebräuchlichsten Serumparameter zur quantitativen Beurteilung der Schilddrüsenfunk-tion -das Gesamtthyroxin (oder proteingebundenes 127 Jod) und der sogenannte Serum-131 J-Tg-Test

show abstract

“…In the majority of cases total T4 was derived from the PBI by multiplication with the factor 1.53. In case the serum was contaminated with exogeneous iodine, total T4 was directly measured using a displacement technique (Herrmann et al, 1970) or by radioimmunoassay (Herrmann et al, 1974). Table 1 shows the serum concentrations of total T3, PBlZ7I, TSH, the free T4 index and the clinical index in the whole experimental group.…”

Section: P a T I E N T S A N D M E T H O D Smentioning

confidence: 99%

Serum Triiodothyronine 7–15 Years After Fractionated Low Dose Radioiodine Therapy of Thyrotoxicosis

Herrmann¹,

Schaps²,

Rusche³

et al. 1975

Clinical Endocrinology

Self Cite

View full text Add to dashboard Cite

In 189 of 334 patients, who had been treated with fractionated doses of radioiodine for Graves' disease 7-15 years ago, the serum concentrations of triiodothyronine have been estimated in additition to the following parameters: Protein bound 127-iodine (PB-127-I), free thyroxine index, cholesterol- and TSH-level in serum, tendon reflex time and clinical index according to Billewitz et al. (1969). In forty-one of the 189 sera the free T4 (AFT4) and free T3 (AFT3) concentrations were measured as well. The following hormonal and clinical patterns were observed: (1) Euthyroidism, with all parameters within the normal range in 148 patients (equals 78-4%). (2) Hypothyroidism with low serum T3, PBI, AFT4, AFT3 and elevated TSH six subjects (equals 3-2%). (3) Persistent hyperthyroidism with increased thyroid hormone concentrations and low TSH in seven cases (equals 3-7%). (4) In twenty-eight clinically euthyroid patients (equals 14-8%) TSH was elevated with normal PBI and AFT4. Twenty of these subjects had a low normal T3 and in nine the T3 was clearly in the hypothyroid range (40 plus or minus 12 mug/dl). (5) The constellation of normal T3, low T4 and elevated TSH, which has been frequently found after radioiodine therapy, has been seen in only moderate form in ten cases.

show abstract

Gesamtthyroxin im Serum

Cited by 4 publications

References 0 publications

Classification of Hypothyroidism in Evaluating Patients after Radioiodine Therapy by Serum Cholesterol, T₃‐Uptake. Total T₄, FT₄‐Index, Total T₃, Basal TSH and TRH‐Test*

Classification of Hypothyroidism in Evaluating Patients after Radioiodine Therapy by Serum Cholesterol, T₃‐Uptake. Total T₄, FT₄‐Index, Total T₃, Basal TSH and TRH‐Test*

Zur Methodik der Bestimmung der ETR (Effective Thyroxine Ratio)

Serum Triiodothyronine 7–15 Years After Fractionated Low Dose Radioiodine Therapy of Thyrotoxicosis

Contact Info

Product

Resources

About

Gesamtthyroxin im Serum

Cited by 4 publications

References 0 publications

Classification of Hypothyroidism in Evaluating Patients after Radioiodine Therapy by Serum Cholesterol, T3‐Uptake. Total T4, FT4‐Index, Total T3, Basal TSH and TRH‐Test*

Classification of Hypothyroidism in Evaluating Patients after Radioiodine Therapy by Serum Cholesterol, T3‐Uptake. Total T4, FT4‐Index, Total T3, Basal TSH and TRH‐Test*

Zur Methodik der Bestimmung der ETR (Effective Thyroxine Ratio)

Serum Triiodothyronine 7–15 Years After Fractionated Low Dose Radioiodine Therapy of Thyrotoxicosis

Contact Info

Product

Resources

About

Classification of Hypothyroidism in Evaluating Patients after Radioiodine Therapy by Serum Cholesterol, T₃‐Uptake. Total T₄, FT₄‐Index, Total T₃, Basal TSH and TRH‐Test*

Classification of Hypothyroidism in Evaluating Patients after Radioiodine Therapy by Serum Cholesterol, T₃‐Uptake. Total T₄, FT₄‐Index, Total T₃, Basal TSH and TRH‐Test*