Gestational age‐adjusted trends and reference intervals of the Modified Myocardial Performance Index (Mod‐MPI) and its components, with its interpretation in the context of established cardiac physiological principles

Bhorat, Ismail; Bagratee, Jayanthilall; Reddy, Tarylee

doi:10.1002/pd.4414

Cited by 25 publications

(51 citation statements)

References 23 publications

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“…With regard to MPI, our data indicate that there is a statistically significant GA-related decrease in LV MPI, though the median value is within the normal range for neonates 6 . Of note, others have observed a GA-related decrease in MPI during fetal development, which is consistent with our findings in preterm infants 27 .…”

Section: Discussionsupporting

confidence: 93%

Maturational Changes in Diastolic Longitudinal Myocardial Velocity in Preterm Infants

Maria

Younoszai

Sontag

et al. 2015

Journal of the American Society of Echocardiography

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Background Doppler tissue imaging (DTI) has been used to evaluate myocardial velocity during ventricular filling, a means of characterizing diastolic function. Previous studies in older children have shown an age-related increase in early diastolic tissue velocities, but there are limited data in preterm infants. The aim of this study was to prospectively determine maturational changes in diastolic tissue velocities at two points in time: 1) 7 days of age, and 2) 36 weeks post-menstrual age (PMA). We further determined whether DTI measures were altered in infants who developed bronchopulmonary dysplasia (BPD) with or without pulmonary hypertension (PH). Methods 277 preterm infants, born at less than 34 weeks PMA, with a birth weight between 500-1250g, were prospectively enrolled. Echocardiograms were performed at 7 days of age and repeated at 36 weeks PMA. Measurements included DTI assessment of early (E’) and late (A’) annular velocities of the left ventricular (LV) free wall septum, and the right ventricular (RV) free wall. Statistical analysis included the Wilcoxon Rank Sum test, simple linear regression, and Chi-square test. Results At 7 days of age, there was a statistically significant increase in E’/A’ ratio as a function of gestational age at birth. At 36 weeks PMA, E’/A’ increased but there was no association with gestational age. DTI measures were not different between infants who did or did not develop BPD or PH at either time point. Conclusions We found a gestational age related increase in the early diastolic tissue velocity of preterm infants. At a gestational age equivalent to near-term, we observed no difference in diastolic tissue velocities regardless of gestational age at birth. Our findings suggest that maturational changes in diastolic function occur relatively independent of the timing of birth.

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Section: Discussionsupporting

confidence: 93%

Maturational Changes in Diastolic Longitudinal Myocardial Velocity in Preterm Infants

Maria

Younoszai

Sontag

et al. 2015

Journal of the American Society of Echocardiography

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“…Another limitation is that the Mod‐MPI requires experience and training to obtain a reliable result. However, this parameter shows very good reproducibility when its evaluation is performed using specific settings with valve clicks as landmarks as shown in our study of reference intervals of the Mod‐MPI in normal pregnancies …”

Section: Discussionmentioning

confidence: 68%

“…B. and J. B. as the operators) for the MPI and its components in our article establishing reference intervals of Mod‐MPI in normal pregnancies …”

Section: Methodsmentioning

confidence: 73%

“…Figure demonstrates the distribution of Mod‐MPI between normal and adverse outcomes in the study group and correlation to the 95th percentile for our normal ranges . Apart from four fetuses, all cases (25) in the study group had elevated Mod‐MPI's (above the 95th percentile).…”

Section: Resultsmentioning

confidence: 88%

“…Distribution of myocardial performance index (MPI) between normal and abnormal outcomes in the study group and correlation to the 95th percentile from the normal ranges study…”

Section: Resultsmentioning

confidence: 99%

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Use of the myocardial performance index as a prognostic indicator of adverse fetal outcome in poorly controlled gestational diabetic pregnancies

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Determination of the myocardial performance index in deteriorating grades of intrauterine growth restriction and its link to adverse outcomes

et al. 2014

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Gestational age‐adjusted trends and reference intervals of the Modified Myocardial Performance Index (Mod‐MPI) and its components, with its interpretation in the context of established cardiac physiological principles

Cited by 25 publications

References 23 publications

Maturational Changes in Diastolic Longitudinal Myocardial Velocity in Preterm Infants

Maturational Changes in Diastolic Longitudinal Myocardial Velocity in Preterm Infants

Use of the myocardial performance index as a prognostic indicator of adverse fetal outcome in poorly controlled gestational diabetic pregnancies

Determination of the myocardial performance index in deteriorating grades of intrauterine growth restriction and its link to adverse outcomes

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