Gestational age and birth weight in relation to aortic stiffness in healthy young adults: two separate mechanisms?

Oren, Ami; Vos, Lydia E; Bos, Willem Jan W.; Safar, Michel E.; Uiterwaal, Cuno S.P.M.; Gorissen, W. H. M.; Grobbee, Diederick E.; Bots, Michiel L.

doi:10.1016/s0895-7061(02)03151-5

Cited by 80 publications

(60 citation statements)

References 9 publications

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“…36 Consequently, prematurity may attenuate the effect of growth retardation on peripheral vascular resistance and endothelial function. 37,38 In conclusion, the present findings of increased vascular reactivity in school children with lower birth weight are consistent with in utero programming of vascular development.…”

Section: Discussionsupporting

confidence: 87%

Cold-induced elevation of forearm vascular resistance is inversely related to birth weight

et al. 2005

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Fetal growth retardation has been linked to elevated blood pressure in adult life. This association between birth weight and blood pressure is present in childhood and is amplified with age. However, the mechanisms that underlie this association are largely unknown. We examined the relationship between birth weight and forearm vascular resistance and forearm blood flow in children aged 9-12.7 years. A total of 58 children were randomly selected from a cohort of 1610 born at the University Hospital of the West Indies in Jamaica where adequate antenatal and delivery records were available. Blood pressure, heart rate and forearm blood flow (by venous occlusion plethysmography) were measured at rest and after cold pressor and mental arithmetic tests.There was a significant inverse correlation between birth weight and the change in the vascular resistance for the cold pressor test (r ¼ À0.47; Po0.001) and the mental arithmetic stress test (r ¼ À0.26; P ¼ 0.05). The log ratio of vascular resistance under stress to resting decreased by 0.289 units per kg of birth weight (95% CI: 0.145-0.434; P ¼ 0.0002). Lower birth weight is associated with increased vascular responsiveness. Increased vascular resistance might be one mechanism linking fetal growth to subsequent elevated blood pressure.

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Section: Discussionsupporting

confidence: 87%

Cold-induced elevation of forearm vascular resistance is inversely related to birth weight

et al. 2005

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“…This is consistent with previous investigations (Fujiwara et al 2004;Mitchell et al 2004). The significant positive correlation found between PWV and age indicates that arteries become less elastic with age, and arterial stiffening was observed with increasing age (Oren et al 2003). Aging induces structural and functional abnormalities such as arterial wall hypertrophy and degeneration or disorganization of the medial layer.…”

Section: Fig 2 Relations Between Bapwv and Bmi In 337supporting

confidence: 92%

Comparison of Brachial-Ankle Pulse Wave Velocity in Japanese and Russians

Liu

Yambe

Zhang

et al. 2005

Tohoku J. Exp. Med.

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Pulse wave velocity (PWV) is a well-known indicator of arterial stiffness and a marker of the presence of vascular lesions. Cardiovascular mortality in Russia has become the highest in the world. The Japanese are enjoying long lives, and the mortality caused by cardiovascular diseases has thus far remained at lower levels than that in Russia. In this study, we focused on brachial-ankle pulse wave velocity (baPWV) obtained from normal human subjects in Russia as well as in Japan, and compared their respective cardiovascular risks. We evaluated baPWV in 337 Japanese and 138 Russian healthy subjects. The baPWV was recorded using a PWV diagnosis device. BaPWV was measured between 2 locations of the arterial tree. The baPWV in the Russian group was significantly higher than that obtained in the Japanese of two groups categorized by age (40-59 years and 60-years). Further, body mass index (BMI), systolic blood pressure (SBP) and diastolic blood pressure in the Russian group were significantly higher than those obtained in Japanese in three age groups (under 39 years, 40-59 years, and 60-years). Moreover, the baPWV indicated a positive correlation with age, BMI and SBP in both Japanese and Russians, although the increasing trend of the baPWV against age of the Russian group had a larger value than that of the Japanese. Therefore, we suggest that arterial stiffness might be promoted earlier in the Russian group, which might be the main cause of the increased cardiovascular risk in Russia.brachial-ankle pulse wave velocity; atherosclerosis; Japanese; Russians

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“…The PWV was determined with the use of a SphygmoCor device (PWV Medical, Sydney, Australia), which allowed an online pulse wave recording and automatic calculation of PWV with two transducers (Millar SPT 301 pressure transducer; Millar Instruments, Sydney, Australia), one positioned at the base or the neck for the common carotid artery and the other over the femoral artery, as previously described [19,20]. The average of 10 successive waveforms was used in the analyses to cover a complete respiratory cycle.…”

Section: Cardiovascular Assessmentsmentioning

confidence: 99%

Alcohol consumption and arterial stiffness in men

Sierksma

Muller

Schouw

et al. 2004

Journal of Hypertension

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Objective Moderate alcohol consumption has been proposed to be anti-atherogenic and protect against coronary heart disease. Arterial stiffness provides a summary measure of atherosclerotic arterial damage and cardiovascular risk. A vascular protective effect of moderate alcohol consumption would be reflected in an inverse association between alcohol intake and aortic stiffness.Design A cross-sectional study.Setting The male population of Utrecht.Participants Of 370 men, aged 40-80 years, alcohol intake was calculated from a standardized questionnaire and aortic stiffness was non-invasively assessed by pulsewave velocity (PWV) measurement of the aorta.Results There were no non-drinkers; therefore the group consuming 0-3 glasses of alcoholic beverage per week was chosen as the reference group in the analyses. Those drinking 4-10, 11-21 and 22-58 glasses of alcoholic beverage per week had a 20.77 m/s (95% confidence interval, 21.26 to 20.28), 20.57 m/s (95% confidence interval, 21.07 to 20.08) and 20.14 m/s (95% confidence interval, 20.65 to 0.36) difference in mean PWV compared with those drinking 0-3 glasses per week. Adjustment for factors that correlated with PWV or alcohol consumption did not change the strength of the association.Conclusion Among men aged 40-80 years there is a J-shaped association between alcohol consumption and PWV. This further supports a decreased risk of cardiovascular disease with moderate alcohol consumption.

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Gestational age and birth weight in relation to aortic stiffness in healthy young adults: two separate mechanisms?

Cited by 80 publications

References 9 publications

Cold-induced elevation of forearm vascular resistance is inversely related to birth weight

Cold-induced elevation of forearm vascular resistance is inversely related to birth weight

Comparison of Brachial-Ankle Pulse Wave Velocity in Japanese and Russians

Alcohol consumption and arterial stiffness in men

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