Gestational and postnatal malnutrition affects sensitivity of young rats to picrotoxin and quinolinic acid and uptake of GABA by cortical and hippocampal slices

Schweigert, Ingrid Dalira; Oliveira, Diogo Lösch de; Scheibel, Fernando; Costa, Fabiane da; Wofchuk, Susana Tchernin; Souza, Diogo O.; Perry, Marcos Luiz Santos

doi:10.1016/j.devbrainres.2004.10.013

Cited by 27 publications

(16 citation statements)

References 71 publications

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“…7) In rats, there are two principal types of PM experimental models: prenatal (i.e., gestation period) and early postnatal (i.e., lactation period) malnutrition. There are many studies focused on body and brain morphological affects of these PM models, such as body and brain weight, 3) hippocampal effects, 8,9) span of basilar dendrities 10) and neocortical effects.…”

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confidence: 99%

Executive Functions of Postweaning Protein Malnutrition in Mice

Sato

Nakagawasai

Tan-No

et al. 2011

Biological & Pharmaceutical Bulletin

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An inadequate supply of nutrition is one of the main nongenetic factors affecting brain development.1) Liu et al. 2) demonstrated that children with malnutrition signs at three years of age tend to have low IQ, excessive motor activity and antisocial behavior in adulthood. In the framework of such nutritional inadequacy, early protein malnutrition (PM) adversely affects central nervous system (CNS) maturation, resulting in long-lasting, or even permanent, deleterious effects. 3,4)Malnutrition is a common problem worldwide and occurs in both developing and developed countries. In developing countries malnutrition is associated with poverty or socioeconomic problems, whereas in developed countries, the weight of the newborn is influenced by the mothers diet 5) and the weight at birth affects subsequent development. 6) Also, in developed countries, severe malnutrition is commonly found in patients with eating disorders which frequently occurs during adolescence leading to interruptions of somatic and psychological development. The use of common weight control techniques by healthy weight adolescents can produce chronic undernutrition. 7)In rats, there are two principal types of PM experimental models: prenatal (i.e., gestation period) and early postnatal (i.e., lactation period) malnutrition. There are many studies focused on body and brain morphological affects of these PM models, such as body and brain weight, 3) hippocampal effects, 8,9) span of basilar dendrities 10) and neocortical effects.11) The prenatal and early postnatal PM also causes various abnormal behaviors, such as increased exploratory behavior, 12,13) reduced anxiety, 13,14) decreased social interaction, 15) increased depressive behavior, 16) increased aggressive behavior, 17,18) prepulse inhibition deficits 19) and impairment of memory-related behavior. [20][21][22] In contrast, there are remarkably few reports concerning postweaning PM effects on the CNS. Lukoyanov and Andrade 23) found that eight months of PM in adult rats induced a marked loss of neurons and synapses in the hippocampal formation and that the morphological alterations led to noticeable impairments in openfield behavior and spatial learning in the water maze. Thus, even if PM begins in adult animals, abnormal behaviors are induced which take a long time to express.The human brain develops rapidly in the last third of pregnancy and the first two years of life. Brain weight increases with age and achieves adult weight between six and 14 years of age. By two years of age the brain is approximately 80% of the adult weight and at one time it was believed that, to a large extent, brain development had ended. More recently it has become apparent that brain development continues through adolescence and even as adults the brain can adapt to changing circumstances. Adolescence is a particularly important time for brain development as more adult ways of thinking emerge: abstract thinking, deductive reasoning and the ability to solve problems. 24) There is increasing evidence that diet...

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mentioning

confidence: 99%

Executive Functions of Postweaning Protein Malnutrition in Mice

Sato

Nakagawasai

Tan-No

et al. 2011

Biological & Pharmaceutical Bulletin

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“…In order to determine the adequate GABA concentration, the assays were based on Schweigert et al (2005). The slices of hippocampus and striatum were previously incubated for 15 min with a HBSS solution.…”

Section: [ 3 H]gaba Uptakementioning

confidence: 99%

Low concentrations of methamidophos do not alter AChE activity but modulate neurotransmitters uptake in hippocampus and striatum in vitro

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“…Em outros, ainda, a desnutrição não modifica a resposta comparativamente aos animais controle 45,46 . Estudos recentes, utilizando modelo de desnutrição protéica pré e pós-natal, mostram maior sensibilidade à picrotoxina, antagonista de receptores GABA A e menor sensibilidade ao ácido quinolínico, hiperestimulador do sistema glutamatérgico em ratos desnutridos em desenvolvimento 47 . Embora sistema-específicos, estes efeitos poderiam expressar alterações na interação entre os sistemas excitatório e inibitório de cuja dinâmica dependem as funções do sistema nervoso central.…”

Section: Desnutrição E Doenças Neuropsiquiátricasunclassified

Desnutrição, maturação do sistema nervoso central e doenças neuropsiquiátricas

2009

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A nutrição exerce profundo impacto no desenvolvimento das estruturas e funções cerebrais. Além da programação metabólica induzida pela desnutrição fetal com o propósito de aumentar as chances de sobrevivência do feto e na vida pós-natal, estudos apontam a deficiência nutricional pré-natal como fator de risco para o desenvolvimento de doenças neuropsiquiátricas. Este artigo propõe-se a considerar aspectos da desnutrição relacionados ao desenvolvimento cerebral, à extensão temporal e funcional do impacto que a mesma acarreta, assim como estabelecer correlações com doenças neuropsiquiátricas, considerando artigos disponíveis na base de dados Medline de 1962 a 2005. Fatos derivados da desnutrição precoce apontam, em sua maioria, caráter permanente em algum grau, se não imediato, prospectivo e comprometedor da performance bioquímica, fisiológica e comportamental. Apesar dos denominados atrasos no desenvolvimento de parâmetros neurológicos, estes não constituem apenas erros funcionais isolados, uma vez que as inter-relações e conexões ideais são influenciadas, ampliando os erros temporais de ocorrência de eventos. A impressão da marca da desnutrição no código genético, ao aumentar os horizontes dos efeitos da desnutrição em uma perspectiva multigeneracional, amplifica os seus efeitos. Aspectos caracterizados como mecanismos compensatórios se, por um lado, apontam para uma habilidade em se adaptar ao estresse, por outro poderiam ser comprometidos na contingência de estresse adicional de ordem ambiental ou emocional. Considerações a respeito dos efeitos subliminares ou expressivos das doenças neuropsiquiátricas sobre a qualidade de vida consolidam a importância do desenvolvimento de pesquisas que se dirijam à compreensão dos impactos e mecanismos que modulam os efeitos da desnutrição sobre o neurodesenvolvimento.

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Gestational and postnatal malnutrition affects sensitivity of young rats to picrotoxin and quinolinic acid and uptake of GABA by cortical and hippocampal slices

Cited by 27 publications

References 71 publications

Executive Functions of Postweaning Protein Malnutrition in Mice

Executive Functions of Postweaning Protein Malnutrition in Mice

Low concentrations of methamidophos do not alter AChE activity but modulate neurotransmitters uptake in hippocampus and striatum in vitro

Desnutrição, maturação do sistema nervoso central e doenças neuropsiquiátricas

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