Gestational Trophoblastic Neoplasia: A Retrospective Study of 23 Cases

Gestational Trophoblastic Diseases at a Tertiary care Hospital in Nepal: A Five Years Retrospective Study

“…Similarly, the cases of GTD were more common in a primigravida with 28(43.08%) cases with decreasing frequencies in subsequent gravida, second gravida, third gravida, fourth gravida, and fifth gravida as 22(33.85%) and nine(13.85%), four(6.15%), two(3.07%) cases respectively. These findings were similar to various studies conducted by Vaithy K et al, Jagtap SV et al, Tanwar RK et al 4,5,7 However, this was in contrast to the study conducted by Anyanwu M et al and Pritam A et al, where GTD was more common in multigravida with 16 (80%) cases and 23 (62.16%) cases respectively. 9,12 In this study, suction and evacuation were performed in almost all cases of hydatidiform moles and hydropic abortus, whereas a hysterectomy was done in one case of choriocarcinoma.…”

“…With a persistent rise in beta-hCG levels and multiple pulmonary nodules on the CT chest, metastasis from choriocarcinoma was diagnosed and the patient was treated with multi-agent chemotherapy following which beta-hCG values returned to their baseline levels. Similarly, a patient presented with ectopic pregnancy was diagnosed to have choriocarcinoma on histopathological examination in the study conducted by Tanwar RK et al 7 Among the cases of GTD, the lowest beta-hCG level was 46.84 mIU/mL and a majority of cases27(41.54%) had beta-hCG levels between 100,000 to <5,00,000 mIU/mL followed by <50,000 mIU/mL in 23(35.38%) cases. This was in contrast to the study conducted by Pritam A et al where serum beta-hCG levels were between 50,000-100,000mIU/mL in 22(59.46%) cases followed by <50,000 in 11(29.73%) cases.…”

“…Likewise, the recurrence rate of moles in future pregnancies is 1-2% from both the complete and partial moles. 6,7 The gestational trophoblastic disease presents with varying clinical and histological features ranging from benign lesions to frank malignancy with evidence of distant metastasis. Early pregnancy vaginal bleeding is the most common clinical presentation along with elevation of B-hCG (usually >10,000 mIU/ml).…”