“…Other mechanisms must, however, also operate in view of (1) patients with mucosal mast cell infiltration and normal villi (Jarnum and Zachariae, 1967;Clemett et al, 1968, case III) and (2) patients with subtotal villous atrophy but no demonstrated increase in mast cells at that site (Rubin and Dobbins, 1965;Broitman et al, 1970). RADIOLOGY A characteristic barium contrast radiological appearance of the small bowel in systemic mast cell disease has been described (Janower, 1962;Remy, 1962;Clemett et al, 1968;Jarnum and Zachariae, 1967). This consists of diffuse thickening of the bowel wall and multiple nodular filling defects similar to the appearance of nodular lymphoid hyperplasia.…”