GH secretion in acute exercise may result in post-exercise lipolysis

Wee, J. S.; Charlton, Catherine; Simpson, Helen; Jackson, Nicola; Shojaee‐Moradie, Fariba; Stolinski, Michael; Pentecost, Claire; Umpleby, AM

doi:10.1016/j.ghir.2005.08.003

Cited by 38 publications

(31 citation statements)

References 35 publications

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“…Recent evidence suggests that an important role for the GH response to exercise is to stimulate lipolysis during the postexercise period (8,24). The findings of the present study support this evidence, since FFA was elevated 4 h after exercise in the Con trial, and when circulating FFA concentrations were very low in the NA trial the GH response to a second bout of exercise was dramatically increased.…”

Section: Discussionsupporting

confidence: 85%

“…The physiological role for exercise-induced GH release is not known, but recent evidence suggests that one key effect is elevated adipose tissue lipolysis and mobilization of free fatty acids (FFA) for use as an energy resource during recovery (24). This assertion is supported by the finding that blockade of GH release using a somatostatin analog inhibits FFA release from subcutaneous abdominal adipose tissue 3 h after exercise (8).…”

mentioning

confidence: 99%

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The growth hormone response to repeated bouts of sprint exercise with and without suppression of lipolysis in men

Stokes¹,

Tyler²,

Gilbert³

2008

Journal of Applied Physiology

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Stokes KA, Tyler C, Gilbert KL. The growth hormone response to repeated bouts of sprint exercise with and without suppression of lipolysis in men. J Appl Physiol 104: 724-728, 2008. First published January 10, 2008 doi:10.1152/japplphysiol.00534.2007.-A single 30-s sprint is a potent physiological stimulus for growth hormone (GH) release. However, repeated bouts of sprinting attenuate the GH response, possibly due to negative feedback via elevated systemic free fatty acids (FFA). The aim of the study was to use nicotinic acid (NA) to suppress lipolysis to investigate whether serum FFA can modulate the GH response to exercise. Seven nonobese, healthy men performed two trials, consisting of two maximal 30-s cycle ergometer sprints separated by 4 h of recovery. In one trial (NA), participants ingested NA (1 g 60 min before, and 0.5 g 60 and 180 min after sprint 1); the other was a control (Con) trial. In conclusion, suppressing lipolysis resulted in a significantly greater GH response to the second of two sprints, suggesting a potential role for serum FFA in negative feedback control of the GH response to repeated exercise. nicotinic acid; endocrinology; negative feedback; humans EXERCISE is one of the most potent physiological stimuli for growth hormone (GH) secretion, and a single 30-s sprint on a cycle ergometer elicits a marked increase in serum GH (20). The physiological role for exercise-induced GH release is not known, but recent evidence suggests that one key effect is elevated adipose tissue lipolysis and mobilization of free fatty acids (FFA) for use as an energy resource during recovery (24). This assertion is supported by the finding that blockade of GH release using a somatostatin analog inhibits FFA release from subcutaneous abdominal adipose tissue 3 h after exercise (8).When two sprints are performed separated by 60 min (21, 22) or 240 min (21) of recovery, the GH response to the second sprint is attenuated. Because serum GH remains elevated for between 90 and 120 min after a single 30-s sprint (23), it is possible that the suppression of the GH response to a second sprint performed within this period is a result of GH autoinhibition at the level of the pituitary (22). The attenuation of the GH response to a second sprint performed after this time (e.g., after 240 min of recovery) may be due to elevated concentrations of systemic FFA (21), which can inhibit GH release at the level of the pituitary (4).The evidence that exercise-induced GH release stimulates FFA mobilization from adipose tissue in the hours after exercise and that elevated FFA can inhibit GH release suggests that the interaction between GH and FFA might represent an important facet of the coordinated regulation of substrate availability during recovery from exercise. Employing nicotinic acid (NA) as an intervention to acutely suppress lipolysis, the aim of this study is to examine the interaction between GH and FFA and to determine whether serum FFA has a negativefeedback role in the regulation of the GH response to repeated exercis...

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Section: Discussionsupporting

confidence: 85%

mentioning

confidence: 99%

The growth hormone response to repeated bouts of sprint exercise with and without suppression of lipolysis in men

Stokes¹,

Tyler²,

Gilbert³

2008

Journal of Applied Physiology

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“…It is unsurprising that any lipolytic effect of the physiologic GH response to exercise would be delayed since GH does not usually begin to increase until at least 10 min of exercise has elapsed and under resting conditions, the maximal lipolytic response to a GH infusion does not occur until approximately 120 min after the infusion has started [107]. Consistent with this, Wee et al demonstrated an increase in lipolysis that reached maximal levels more than two hours after 20 min of exercise at 70% of VO 2max in healthy subjects [108], and the magnitude of which correlated with the peak GH response to exercise. In the same study, a similar effect was reproduced under resting conditions using an infusion of GH calculated to mimic the GH response to exercise.…”

Section: Studies In Normal Subjectsmentioning

confidence: 90%

The physiology of growth hormone and sport

Widdowson

Healy

Sönksen

et al. 2009

Growth Hormone & IGF Research

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“…The increase in glycerol levels post exercise compared to recovery is also most likely a result of two phenomena, 1) increased fuel mobilization during exercise to fuel the increased demands of intense exercise and, 2) the previously mentioned peripheral increased fuel uptake post exercise to replenish energy stores used during exercise. Wee et al [37] showed an increase in glycerol following a 20 minute bout of submaximal exercise (cycling at 70% of VO 2 max) followed by a sharp decline in the initial recovery phase, hours into recovery from exercise they observe additional increases in glycerol levels. The magnitude of increase that they observed is much greater than ours, but this is most likely due to the fact that our initial post exercise assessment occurs significantly later than theirs.…”

Section: Discussionmentioning

confidence: 99%

Changes in Salivary and Plasma Markers during and Following Short-Term Maximal Aerobic Exercise Assessed during Cognitive Assessment

Bue-Estes¹,

Horvath²

2016

ABB

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This study assessed multiple salivary and plasma markers before and after incremental shortterm maximal aerobic exercise and in a non-exercising control in conjunction with cognitive testing. Subjects: Apparently healthy 18 -30 years old low CVD risk females participated (n = 19). Methods: Subjects completed two conditions: 1) exercise: short maximal treadmill exercise and cognitive assessment pre-and post-exercise and, 2) non-exercise: with cognitive assessment timed to match testing in the exercising condition. Non-stimulated, timed salivary samples and venous blood were collected before and after exercise and after recovery. Results: Saliva: Over time α-amylase increased in both exercise and non-exercising conditions. Exercise had increases in α-amylase at time matched control points up to 36% greater than the non-exercising conditions. Following exercise and recovery from exercise α-amylase increased compared to baseline (ranging from 47% to 290%). Baseline cortisol was 33% higher than post-exercise and 59% higher than recovery irrespective of exercise. Plasma: NEFA was 50% higher at post-exercise and recovery compared to baseline without exercise and 36% higher at post-exercise and recovery compared to baseline with exercise. Glucose and lactate were, 18% and 50% higher respectively, after exercise compared to baseline and recovery with exercise. Post-exercise glycerol was 11% higher than recovery. Differences between Conditions: Post-exercise glucose and lactate were 20% and 40% higher respectively with exercise. Glycerol was 11% lower after exercise. Conclusions: We demonstrated that acute exercise coupled with cognitive task increased α-amylase levels, but not cortisol, potentially due to a differential stress response, but most likely due to the timing of sample collection.

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GH secretion in acute exercise may result in post-exercise lipolysis

Cited by 38 publications

References 35 publications

The growth hormone response to repeated bouts of sprint exercise with and without suppression of lipolysis in men

The growth hormone response to repeated bouts of sprint exercise with and without suppression of lipolysis in men

The physiology of growth hormone and sport

Changes in Salivary and Plasma Markers during and Following Short-Term Maximal Aerobic Exercise Assessed during Cognitive Assessment

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