2008
DOI: 10.1111/j.1365-2265.2008.03278.x
|View full text |Cite
|
Sign up to set email alerts
|

Ghrelin in small‐for‐gestational age (SGA) newborn babies: a cross‐sectional study

Abstract: We interpreted these findings to indicate that diminished body weight in newborns induce different adaptive signals, some of them mediated by IGF-1/IGFBP-3, ghrelin or by IGFBP-1. This regulation is congruent with the proposed role of ghrelin to adaptation to under-nutrition favouring lipid accumulation. CONCyTEG grant number 05-16-K117-028.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

3
15
0

Year Published

2009
2009
2024
2024

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 23 publications
(19 citation statements)
references
References 38 publications
3
15
0
Order By: Relevance
“…Eventually, the higher ghrelin concentrations may serve to stimulate appetite, resulting in higher nutritional intake by the IUGR neonate after birth (126). In agreement, both higher ghrelin levels and hyperphagia have postnatally been demonstrated in human and animal IUGR subjects, suggesting a role for ghrelin in postnatal catch-up growth (91,128,129).…”
Section: Ghrelin In Iugrmentioning
confidence: 66%
“…Eventually, the higher ghrelin concentrations may serve to stimulate appetite, resulting in higher nutritional intake by the IUGR neonate after birth (126). In agreement, both higher ghrelin levels and hyperphagia have postnatally been demonstrated in human and animal IUGR subjects, suggesting a role for ghrelin in postnatal catch-up growth (91,128,129).…”
Section: Ghrelin In Iugrmentioning
confidence: 66%
“…Recently, some analyses have been conducted, concerning ghrelin levels in SGA children. It has been proved that ghrelin concentration is higher in SGA than in born appropriate for gestational age (AGA) newborns [7][8][9]; however, the number of studies regarding the ghrelin concentration in SGA children during the prepubertal period after the catch-up process is rather scarce [10,11] and the results are divergent. We have tested the hypothesis that in SGA children high concentrations of ghrelin (seen in cord blood) are maintained during the prepubertal period and are responsible, in part, for lipids and carbohydrates metabolism disturbances due to the stimulation of the orexigenic axis.…”
Section: Introductionmentioning
confidence: 98%
“…There are several studies in which data are presented on the influence of adipocytokines on lipids and glucose metabolism in SGA children in order to clarify mechanisms leading to metabolic disorders observed in adolescents and adults born SGA. Leptin, which has a competitive interaction with ghrelin in feeding regulation, is low in cord blood of SGA neonates [7,9]. In turn, high resistin levels were found in cord blood of SGA children [9,12].…”
Section: Introductionmentioning
confidence: 99%
“…Ghrelin is found in human fetal circulation during gestation. Small for gestational age (SGA) newborns show ghrelin levels higher than in adequate for gestational age (AGA) or large for gestational age neonates ( LGA) (10,11). The widely held hypothesis is that ghrelin could have an anabolic role at the beginning of meals and in energy balance; however, there is limited evidence to support this theory (4).…”
Section: Introductionmentioning
confidence: 98%