Ghrelin inhibits early brain injury due to subarachnoid hemorrhage via the Tim-3-mediated HMGB1/NF-κB pathway

Qiu, Jiaoxue; Guo, Lei; Li, Wenna; Wang, Lingling; Tong, Lin

doi:10.1016/j.jchemneu.2022.102138

Cited by 2 publications

(1 citation statement)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…DAMPs, an innate immune response to molecules released from the extracellular and intracellular space of damaged tissue or dead cells, are essential in response to inflammation progression [ 66 ]. Notably, the high-mobility group protein B1 (HMGB1), a typical DAMP, plays an integral role in the regulation of neuroinflammation following a SAH [ 67 , 68 ]. After a SAH, HMGB1, released from necrotic neurons, could induce cytokine release and leukocyte recruitment and then trigger the inflammatory response after interaction with TLR4 and the receptor for advanced glycation end products (RAGEs) [ 69 ].…”

Section: The Therapeutic Role Of Sirt1 In Sahsmentioning

confidence: 99%

The Critical Role of Sirt1 in Subarachnoid Hemorrhages: Mechanism and Therapeutic Considerations

et al. 2023

View full text Add to dashboard Cite

The subarachnoid hemorrhage (SAH) is an important cause of death and long-term disability worldwide. As a nicotinamide adenine dinucleotide-dependent deacetylase, silent information regulator 1 (Sirt1) is a multipotent molecule involved in many pathophysiological processes. A growing number of studies have demonstrated that Sirt1 activation may exert positive effects on SAHs by regulating inflammation, oxidative stress, apoptosis, autophagy, and ferroptosis. Thus, Sirt1 agonists may serve as potential therapeutic drugs for SAHs. In this review, we summarized the current state of our knowledge on the relationship between Sirt1 and SAHs and provided an updated overview of the downstream molecules of Sirt1 in SAHs.

show abstract

Section: The Therapeutic Role Of Sirt1 In Sahsmentioning

confidence: 99%

The Critical Role of Sirt1 in Subarachnoid Hemorrhages: Mechanism and Therapeutic Considerations

et al. 2023

View full text Add to dashboard Cite

show abstract

Ghrelin attenuates the inflammatory response induced by experimental endotoxemia in mice

Majid,

Baqir,

Al-Shimerty

et al. 2024

Wiad Lek

View full text Add to dashboard Cite

Aim: The aim of this research is to assess the anti-inflammatory effect of ghrelin in mice models of polymicrobial sepsis. Materials and Methods: 35 male albino Swiss mice, ages 8-12 weeks, weighing 23-33g, were randomly separated into five groups n = 7; normal group was fed their usual diets until time of sampling, the sham group subjected to Anaesthesia and laparotomy, sepsis group subjected to cecal ligation and puncture, vehicle group was given an equivalent volume of intraperitoneal saline injections immediately after cecal ligation and puncture, and the ghrelin group was treated with 80 μg/kg of ghrelin intraperitoneal injections immediately following cecal ligation and puncture. Twenty hours after cecal ligation and puncture, mice were sacrificed; myocardial tissue and serum samples were collected. Serum IL-1β, NF-κB, and TLR4 levels were measured, and inflammatory response’s effects on cardiac tissue were evaluated. Results: The mean serum IL-1β, NF-κB, and TLR4 levels were markedly elevated in the sepsis and vehicle groups than in the normal and sham groups. The mean serum levels of IL-1β, NF-κB, and TLR4 were considerably lower in the ghrelin-treated group than in the vehicle and sepsis groups. Myocardium tissue of the normal and sham groups showed normal architecture. The sepsis and vehicle groups had a severe myocardial injury. The histological characteristics of ghrelin-treated mice differed slightly from those of the normal and sham groups. Conclusions: Our study concluded that ghrelin exerts anti-inflammatory effects in polymicrobial sepsis, as indicated by a considerable decrease in the IL-1β, NF-κB and TLR4 serum levels.

show abstract

Ghrelin inhibits early brain injury due to subarachnoid hemorrhage via the Tim-3-mediated HMGB1/NF-κB pathway

Cited by 2 publications

References 26 publications

The Critical Role of Sirt1 in Subarachnoid Hemorrhages: Mechanism and Therapeutic Considerations

The Critical Role of Sirt1 in Subarachnoid Hemorrhages: Mechanism and Therapeutic Considerations

Ghrelin attenuates the inflammatory response induced by experimental endotoxemia in mice

Contact Info

Product

Resources

About