Ghrelin, Nitrite and Paraoxonase/Arylesterase Concentrations in Cement Plant Workers

Abstract

Kratak sadr`aj: Izlaganje cementnoj pra{ini na radnom mestu povezano je s pove}anim rizikom od promena na jetri, plu}nih bolesti i nastanka kancera. Mogu}i mehanizmi koji uzrokuju bolesti su smanjeni antioksidativni kapacitet i po vi{e na lipidna peroksidacija u plazmi. U skladu s tim, u ovoj studiji prou~avani su nivoi paraoksonaze (PON1) -arilesteraze (AE), grelina, HDL-C, LDL-C i nitrita (NOx) u serumu kod radnika izlo`enih cementnoj pra{ini. U studiji je u~e stvovalo dvadeset osam radnika u cementari i 30 dobro voljaca (kontrola), starosti 29-54 godine. Koncentra cije PON1, AE, NOx, grelina i HDL-holesterola i LDL-holesterola u serumu merene su u obe grupe. PON-1, AE, grelin i HDL-holesterol bili su ni`i kod radnika u cementari nego u kontrolnoj grupi. Nivoi nitrita i LDL-C u serumu kod radnika u cementari bili su vi{i (p<0,05) nego u kontrolnoj grupi radnika. Nije prime}ena korelacija izme|u nivoa HDL-holesterola i PON1 u serumu, kao ni izme|u HDL-holesterola i grelina. Slaba nega tivna korelacija otkrivena je izme|u grelina i NOx u serumu. Rezultati studije sna`no ukazuju na to da HDL-paraoksonaza, AE, grelin, HDL-C i visoki nivoi NOx i LDL-C verovatno igraju ulogu u bolesti koja uklju~uje oksidativna o{te}enja. Me|utim, potrebna su dalja istra`ivanja kako bi se ispitala veza izme|u izlaganja pra{ini na radnom mestu i respiratornih simptoma.

Impact of cement factory operations on air quality and human health in Ewekoro Local Government Area, South-Western Nigeria

“…For instance, human exposure to cement dust has been shown to induce several respiratory, mutagenic and gastrointestinal disorders [11][12][13]. According to Aydin et al [14], Al-Neaimi et al [15] and Alvear-Galindo et al [16], occupational exposure to cement dust is associated with an increased risk of liver abnormalities, pulmonary disorders and carcinogenesis. Similarly, cases of chest pain, cough and eye problems were prevalent among village residents that were exposed to cement dust [17].…”

Impact of cement dust pollution on respiratory systems of Lafarge cement workers, Ewekoro, Ogun State, Nigeria

“…Cement dust also irritate the skin, mucous membrane of the eyes and the respiratory system in general. The deposition of cement dust in the respiratory tract leads to increased pH values which irritate the exposed mucous membranes and impair respiration (Mwaiselage et al, 2005, Fell et al, 2003, Aydin et al, 2010and Zeleke et al, 2010.…”

Ghrelin and melatonin as biomarkers in patients with giardiasis

“…[32] Further research is needed to throw more light on the complex relationships between serum ghrelin and HDL levels and the enhanced lipid peroxidation in patients with parasitic infections. [33] Final remarks Overall, our results showed that the serum ghrelin concentration was significantly decreased in patients infected with G. lamblia as compared to the healthy group (Figure 1), whereas the serum melatonin (Figure 2), serum glucose ( Figure 3) and serum cholesterol (Figure 4) levels were significantly increased in giardiasis patients as compared to the healthy group. However, it should be noted that our research included a relatively small number of male patients only.…”