GHRH and sleep

Obál, F.; Krueger, James M.

doi:10.1016/j.smrv.2004.03.005

Cited by 149 publications

(100 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…25 If endogenous GHRH is a physiological NREMSregulatory substance, then its suppression should be associated with decreases in NREMS. 13 This point of view has been widely studied. A competitive GHRH antagonist 26 elicited dose-dependent decreases in the duration and intensity of NREMS and increases in sleep latency.…”

Section: Growth Hormone-releasing Hormone (Ghrh)mentioning

confidence: 99%

“…13 SRIH has five receptors named sst1 to SST5. Inhibition of the somatotropic axis is mediated by the SST2 receptors.…”

Section: Somatostatin (Srih) and Analoguesmentioning

confidence: 99%

“…12 Obviously, bidirectional interactions exist between sleep and the endocrine system. 13 Several hormones have the capacity to affect sleep but the physiological significance of hormonal modulation of sleep is generally unclear. Plasma concentrations of many hormones display sleep-related variations, suggesting that sleep influences hormone secretion.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Hormones, hormonal agents, and neuropeptides involved in the neuroendocrine regulation of sleep in humans

Kotronoulas

Stamatakis²,

Stylianopoulou³

2009

View full text Add to dashboard Cite

Sleep is an essential ubiquitous biological process, a periodical state of quiescence in which there is minimal processing of sensory information and no interaction with conspecifics or the environment. Despite relevant research on sleep structure and testing of numerous endogenous sleep-affecting chemicals, questions as to the precise mechanisms and functions of sleep remain without satisfactory responses. The purpose of this review is to report on current evidence as regards the effect of several endogenous and exogenous hormones, hormonal agents, and neuropeptides on sleep onset or wake process, when administered in humans in specific doses and via different routes. The actions of several peptides are presented in detail. Some of them (growth hormone releasing hormone, ghrelin, galanin, neuropeptide Y) seem to promote sleep, whereas others (corticotropin, somatostatin) impair its continuity.

show abstract

Section: Growth Hormone-releasing Hormone (Ghrh)mentioning

confidence: 99%

“…13 SRIH has five receptors named sst1 to SST5. Inhibition of the somatotropic axis is mediated by the SST2 receptors.…”

Section: Somatostatin (Srih) and Analoguesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hormones, hormonal agents, and neuropeptides involved in the neuroendocrine regulation of sleep in humans

Kotronoulas

Stamatakis²,

Stylianopoulou³

2009

View full text Add to dashboard Cite

show abstract

“…Consistent with this are the following findings: (1) GH administration increases REM sleep in rats (Drucker-Colin et al, 1975) and (2) exogenous application of growth hormone releasing hormone (GHRH), the hypothalamic neurohormone stimulating GH secretion, promotes non -rapid eye movement (NREM) sleep in various species, while suppression of endogenous GHRH results in simultaneous inhibition of NREM (Obal and Krueger, 2004). Several early studies employed the use of protein synthesis inhibitors (PSIs) to examine this question.…”

mentioning

confidence: 79%

Administration of the protein synthesis inhibitor, anisomycin, has distinct sleep-promoting effects in lateral preoptic and perifornical hypothalamic sites in rats

et al. 2008

View full text Add to dashboard Cite

Although a robust relationship between sleep and increased brain protein synthesis is welldocumented, there have been few reports of the effects of local application of a protein synthesis inhibitor (PSI) on sleep. In this study, we compared the effects of local microdialytic administration of the protein synthesis inhibitor, anisomycin (ANI) into the lateral preoptic area (LPOA), a sleep promoting area vs. the perifornical/lateral hypothalamus (PF / LH), a wake and rapid eye movement (REM) sleep-promoting area. ANI administered to the LPOA at night resulted in an increase in stage 2 of rat non-REM sleep, whereas ANI delivered into the PF/LH during the daytime increased REM sleep. ANI microdialysis into hippocampus did not affect sleep or waking. These differential effects of local protein synthesis inhibition on sleep support a hypothesis that mechanisms controlling protein synthesis are critically involved in the regulation of both NREM sleep and REM sleep.

show abstract

“…Somos conscientes de que existe una paradoja difícil de salvar cognitivamente: por una parte el SFM no es una enfermedad mental ni es el producto de un confl icto psicológico, por otra es necesario un abordaje ciado con el sueño profundo no REM, la propia GH lo está con la fase REM, equilibrando entre ambos el anabolismo tisular durante el sueño (Obal y Krueger, 2004). La secreción de GH-RH depende de la región preóptica del hipotá-lamo anterior, precisamente la misma zona que se ocupa de la regulación del sueño (Peterfi , Makara, Obal, y Krueger, 2009).…”

Section: Alteración Del Sistema Inmune: Disritmiaunclassified

Una visión psiconeuroinmunológica de la fibromialgia

Álvaro¹,

Traver²

2010

RPPC

View full text Add to dashboard Cite

Resumen: El síndrome de fi bromialgia (SFM) es el síndrome de dolor crónico que se encuentra con mayor frecuencia en medicina general. Junto a una miríada de alteraciones inespecífi cas biológicas y sintomáticas, la evidencia sugiere un procesamiento anómalo del dolor a nivel central en ausencia de disfunción periférica y en ausencia de enfermedad. Alteraciones emocionales o psiquiátricas inciden sobre los sistemas nervioso, endocrino e inmune, que explican a través del eje psico-neuro-inmuno-endocrinológico un desequilibrio homeostático que se traduce en forma de disautonomía y disritmia y explica las alteraciones del sistema nervioso vegetativo, del ritmo circadiano, del sueño, hormonales e inmunes y abre un nuevo horizonte de manejo y tratamiento del SFM. Los tratamientos no medicamentosos capaces de equilibrar este triángulo homeostático van desde la terapia de comportamiento de enfoque cognitivo, la hipnoterapia, métodos de biofeedback electromiográfi co, ejercicio físico moderado y acupuntura, sin olvidar una atención especial al restablecimiento del ritmo circadiano y a la mejora de la calidad del sueño.Palabras clave: Síndrome de fi bromialgia, psiconeuroinmunología, alteraciones del sueño, dolor, disautonomía. A psychoneuroimmunological view of fi bromyalgiaAbstract: Fibromyalgia syndrome (FSM) is the chronic pain syndrome most frequently found in general medicine. Along with a myriad unspecifi c biological and symptomatic alterations, the evidence points at anomalous pain processing at a central level, in the absence of peripheral dysfunction or illness. Emotional or psychiatric alterations affect the nervous, endocrine and immune systems which explains, through the psycho-neuro-immune-endocrinologic axis, the homeostatic imbalance that gives rise to dysautonomia and dysrhythmia and fi nally explains alterations of the vegetative nervous system, of the circadian rhythm and sleep, hormonal and immune rhythms, and opens a new horizon as to handling and treatment of FSM. Non-drug treatments, capable of balancing this homeostatic triangle, go from cognitive-behavior therapy to hypnotherapy, forms of electromyographic biofeedback, moderate physical exercise and acupuncture, not forgetting a special attention to re-establishing the circadian rhythm and to improve sleep quality.

show abstract

GHRH and sleep

Cited by 149 publications

References 53 publications

Hormones, hormonal agents, and neuropeptides involved in the neuroendocrine regulation of sleep in humans

Hormones, hormonal agents, and neuropeptides involved in the neuroendocrine regulation of sleep in humans

Administration of the protein synthesis inhibitor, anisomycin, has distinct sleep-promoting effects in lateral preoptic and perifornical hypothalamic sites in rats

Una visión psiconeuroinmunológica de la fibromialgia

Contact Info

Product

Resources

About