“Giant-cell” and “strand-forming” cytopathic effect of measles virus lines conditioned by serial propagation with diluted or concentrated inoculum

Canine distemper virus in primary and continuous cell lines of human and monkey origin

“…Continued passage of undiluted inocula of CDV resulted in decreased CPE and virus yields, an observation similar to that described by Oddo, Flaccomio and Sinatra (1961) with measles virus in HeLa cells. However, in the present study a variant was obtained by the terminal dilution technique which was not affected by this "autoinhibition".…”

Effect of Certain Polypeptides on the Biological Activities of Measles Virus

“…The heteroploid green monkey kidney cell line Vero was used for propagation of the non-autointerfering (DP, diluted passage) variant of the Edmonton strain (12) Peptides. In addition to the previously obtained (10) tripeptide, SV-4814 [Z-D-Phe-Phe-Arg(NO,) ] the different dipeptides described in Table 1 and the first four tripeptides described in Table 2 were kindly provided by Parke, Davis & Co., Detroit, Mich.…”

An interferon-like inhibitor as a possible factor in the selection of measles virus variants

“…It seems likely that most of the characteristics which distinguish the "10 ~ from the "10 -2" line are consequences of the ability of the "10 ~ virus to induce the formation of the interferon-like inhibitor (2,3,5,6,7,8,9,10).…”

“…In experiments of mixed infection with both lines of measles virus, the "10 o" line markedly inhibits giant cell formation and reduces the yield of giant cell virus (2,6). Pre-treatment of HeLa cell monolayers with "10 ~ virus inactivated at 56~ notably inhibits plaque formation by the "10 -2'' virus, whereas pre-treatment with inactivated "10 -2'' virus has no effect on plaque formation (6).…”