Giant Cell Carcinoma of the Lung

Laforga, Juan B.

doi:10.1159/000330990

Cited by 9 publications

(3 citation statements)

References 6 publications

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“…There have been only a few cytological studies of GC [12,13]. GC cytology specimens have exhibited numerous mono- or multinucleate giant cells with significant pleomorphism in size and shape.…”

Section: Discussionmentioning

confidence: 99%

“…Their cytoplasm is occasionally infiltrated with neutrophils. The tumor cells usually occurred singly, and the background contains tumor diathesis with numerous polymorphonuclear leukocytes [12,13]. …”

Section: Discussionmentioning

confidence: 99%

“…Because of the difficulty in making a definite diagnosis of PC or GC, it is not clear whether the prognosis of patients with those tumors in the advanced stage is worse than that for patients with other NSCLCs. Although cytological findings of PC or GC have been documented in a few reports [8,9,10,11,12,13], there have been no multi-institutional studies carried out by pulmonary cytopathologists. The aim of this study was to elucidate the cytological characteristics of PC or GC with specimens obtained from the touch imprints of surgically removed tumors or pre-operative transbronchial cytology specimens in patients whose tumor was surgically removed and confirmed histologically to be PC or GC, and to extend application of those findings to specimens obtained from brushing or curettage of advanced-stage tumors.…”

Section: Introductionmentioning

confidence: 99%

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Cytological Characteristics of Pulmonary Pleomorphic and Giant Cell Carcinomas

Hiroshima

Dosaka‐Akita²,

Usuda³

et al. 2011

Acta Cytologica

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Objective: To establish cytological features of pulmonary pleomorphic carcinoma (PC) or giant cell carcinoma (GC), we evaluated the cytological characteristics of these tumors using a multidisciplinary approach. Study Design: Samples from 13 surgically resected and histologically confirmed PC or GC patients were collected from our institutes. Eight cases without prior chemotherapy before surgery were selected, and cytological features were analyzed. Results: The background contained numerous lymphocytes and neutrophils. The tumor cells were arranged in flat loose clusters, but some were in fascicles. The shape of the tumor cell was spindle or pleomorphic, and the sizes of the tumor cells varied by more than 5-fold. The tumor cells had an abundant, thick and well-demarcated cytoplasm. The location of the nucleus was centrifugal, and the nucleus was oval or irregularly shaped. Multinucleated giant cells were frequently observed. The size of the nucleus was more than 5 times that of normal lymphocytes, and its size also varied by more than 5-fold. The nuclear membrane was thin, and nuclear chromatin was coarsely granular, while the nucleolus was single and round. Conclusion: PC or GC has characteristic cytological features, however, spindle cells tended to be hardly observed in cytological specimens in some cases.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%