Giant Cell Hepatitis in Two Young Cats.

Suzuki, Kazuhiko; Nakayama, Hiroyuki; Doi, Kunio

doi:10.1292/jvms.63.199

Cited by 3 publications

(4 citation statements)

References 7 publications

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“…6 However, to our knowledge, malignant cells with multilobulated nuclei, such as those seen in this case, have been described infrequently in the veterinary literature. [6][7][8][9] Multinucleated cells described previously 9 were bigger and did not contain multilobulated nuclei nor resemble the cells described in this report. Large granular lymphocytes with mononuclear morphology 8 were smaller and contained azurophilic cytoplasmic granules.…”

Section: Discussionmentioning

confidence: 65%

“…[10][11][12][13][14] Similar cells with multilobulated nuclei have been infrequently described from canine and feline specimens. [6][7][8][9] In the cat in the present case, multilobulated cells with a flower cell appearance were interpreted to represent lymphoma of B-cell origin. We also identified 5 other cases with similar cells, but none of these cell populations were of pure T-cell origin (cells in case 6 were of mixed T-cell and myeloid cell origin).…”

Section: Discussionmentioning

confidence: 90%

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Multilobulated “flower” cells in a subcutaneous mass aspirate from a cat

Fritz

Freeman

Hopfner

et al. 2005

Veterinary Clinical Pathol

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An 8-year-old intact male cat was presented with a subcutaneous mass in the region of the right jugular vein. Cytologic and histopathologic examinations revealed cells with multilobulated nuclei (flower cells). Immunochemistry using a panel of markers showed vimentin-positivity on cytologic specimens, and postive staining for CD79a and BLA36 on histologic specimens. The final diagnosis was lymphoma of B-cell origin. We have observed similar multilobulated cells in ascites fluid, thoracic fluid, and peripheral blood from dogs and cats with a variety of lymphoid and myeloid neoplasms. Cells with multilobulated nuclei that resemble flower petals also have been described in humans. These cells are infrequently observed in canine and feline cytology specimens and require immunochemistry to determine their cell of origin.

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Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 90%

Multilobulated “flower” cells in a subcutaneous mass aspirate from a cat

Fritz

Freeman

Hopfner

et al. 2005

Veterinary Clinical Pathol

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“…Immunohistochemistry on the livers for FeLV, FIV, feline syncytial virus, feline herpesvirus and feline parvovirus were all negative. Electron microscopic preparations were negative for viral particles and showed no cell membrane remnants in the multinucleated hepatocytes, suggesting a failure of hepatocyte division (cytokinesis) rather than cell fusion 49 . Giant cell hepatitis, characterised by formation of multinucleated hepatocytes, is found in human neonates and infants and is called 'post-infantile giant cell hepatitis' (PIGCH), but is rare in adults.…”

Section: Introductionmentioning

confidence: 98%

“…Other causes in humans include viral infection (rubella, cytomegalovirus, reovirus 8 , papillomavirus 17 , and HIV infection of children 26 ), trisomy 17-18 syndrome 8 , and drug intoxication. In many cases the aetiology is obscure 49 . Non-A non-B hepatitis in humans causes hepatocyte dysplasia, this referring to cellular enlargement, nuclear hyperchromatism, multinucleation (3-5 nuclei per cell, affected cells usually in a pericentral or periportal location) and multiple nucleoli of individual hepatocytes or clusters thereof.…”

Section: Introductionmentioning

confidence: 99%

Renal medullary AA amyloidosis, hepatocyte dissociation and multinucleated hepatocytes in a 14-year-old free-ranging lioness (Panthera leo)

Williams¹,

Wilpe²,

Momberg³

2005

J. S. Afr. Vet. Assoc.

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A 14-year-old lioness, originating from Etosha in Namibia, and a member of a pride in Pilanesberg National Park since translocation in 1994, was euthanased due to fight-related vertebral fracture and spinal injury, incurred approximately 6-8 weeks previously. Blood specimens collected at the time of death showed mild anaemia and a leukogram reflecting stress and chronic infection. Necropsy conducted within 2 hours of death was on a dehydrated, emaciated animal with hindquarter wasting and chronic traumatic friction injuries from dragging her hindlegs. There was cellulitis in the region of bite-wounds adjacent to the thoraco-lumbar vertebral fracture, at which site there was spinal cord compression, and there was marked intestinal helminthiasis. The outer renal medullae appeared pale and waxy and the liver was macroscopically unremarkable. Histopathology and electron microscopy of the kidneys revealed multifocal to coalescing deposits of proximal medullary interstitial amyloid, which fluoresced strongly with thioflavine T, and was sensitive to potassium permanganate treatment prior to Congo Red staining, thus indicating inflammatory (AA) origin. There was diffuse hepatocyte dissociation, as well as numerous binucleated and scattered multinucleated (up to 8 nuclei/cell) hepatocytes, with swollen hepatocyte mitochondria, in liver examined light microscopically. Ultrastructurally, the mono-, bi- and multinucleated hepatocytes contained multifocal irregular membrane-bound accumulations of finely-granular, amorphous material both intra-cytoplasmically and intra-nuclearly, as well as evidence of irreversible mitochondrial injury. The incidence and relevance in cats and other species of amyloidosis, particularly with renal medullary distribution, as well as of hepatocyte dissociation and multinucleation, as reported in selected literature, is briefly overviewed and their occurrence in this lioness is discussed.

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Inflammatory Diseases of the Liver and Biliary Tract

2007

Jubb, Kennedy &Amp; Palmer's Pathology of Domestic Animals

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Giant Cell Hepatitis in Two Young Cats.

Cited by 3 publications

References 7 publications

Multilobulated “flower” cells in a subcutaneous mass aspirate from a cat

Multilobulated “flower” cells in a subcutaneous mass aspirate from a cat

Renal medullary AA amyloidosis, hepatocyte dissociation and multinucleated hepatocytes in a 14-year-old free-ranging lioness (Panthera leo)

Inflammatory Diseases of the Liver and Biliary Tract

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