Giant cell-rich osteosarcoma – A rare case

Mallick, Aishika; Shah, Neha; Mahmud, Sk Abdul; Das, Sanjeet Kumar

doi:10.4103/jomfp.jomfp_251_19

Cited by 13 publications

(12 citation statements)

References 8 publications

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“…The term “Osteosarcoma” introduced by Alexis Boyer in 1805[ 3 ] refers to a heterogeneous group of primary malignant neoplasms affecting bone-forming or mesenchymal tissue that have histopathologic evidence of osteogenic differentiation. OS of the head and neck is considered by most clinicians to be distinct clinically from OS that arises in the long bones.…”

Section: Discussionmentioning

confidence: 99%

“…[ 1 ] OS of the jaws OS (JOS) is infrequent as compared to their skeletal counterparts comprising nearly about 6%–13% of all known cases of OS and 2.1% of all malignant oral and maxillofacial tumors. [ 2 3 4 ] Incidence of new cases of JOS is said to be around 0.07 in 100,00/year. [ 4 ]…”

Section: Introductionmentioning

confidence: 99%

“…The conventional OS predominantly comprises the osteoblastic, chondroblastic and fibroblastic variants depending on cellular atypia and type of extracellular matrix, produced by the tumor cells. [ 3 ] Despite histopathological similarities of JOS with OS of the long bones, it is biologically different. JOS is known to have a comparably higher survival rate and a lower incidence of metastasis than OS occurring in other areas of the body.…”

Section: Introductionmentioning

confidence: 99%

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Osteosarcoma

Manchanda¹,

Narang²,

Mahajan³

2021

Journal of Oral and Maxillofacial Pathology

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Osteosarcoma (OS) comprises 2.1% of all malignant oral and maxillofacial tumors. OS arising from the jaw OS differs from OS of the long bones in its biological behavior, presenting a lower incidence of metastasis and a better prognosis. The morphologic and behavioral heterogeneity observed in OS and the perplexity of the varied histological features mimicking other primary and metastatic bone tumors has emphasized the need of advanced molecular techniques in its diagnosis. Hereby, we present a case of OS which was diagnosed by immunohistochemical analysis, aiding in establishing its histogenetic origin.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Osteosarcoma

Manchanda¹,

Narang²,

Mahajan³

2021

Journal of Oral and Maxillofacial Pathology

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“…2 Osteosarcoma is subdivided histopathologically into osteoblastic, chondroblastic, or fibroblastic, depending on the cellular atypia and the type of the extracellular matrix, produced by the tumor cells. 3,4,5 In most cases, the presence of malignant osteoid matrix among malignant cells is pathognomonic of osteosarcoma. 2 Giant cell-rich osteosarcoma (GCRO), an extremely rare histologic variant, constituting about 1%-3% of conventional osteosarcoma, shows numerous osteoclastlike giant cells and variable amount of tumor osteoid.…”

Section: Introductionmentioning

confidence: 99%

“…2 Giant cell-rich osteosarcoma (GCRO), an extremely rare histologic variant, constituting about 1%-3% of conventional osteosarcoma, shows numerous osteoclastlike giant cells and variable amount of tumor osteoid. 4,5 Neoadjuvant chemotherapy along with conventional surgery, mostly limb salvage treatment, effectively improves the survival rate. 2,3 Here, we present a rare case of diagnosis made by fluid cytology.…”

Section: Introductionmentioning

confidence: 99%

Osteosarcoma: a fluid cytologic diagnosis

Asokan

Chander

2023

Int J Res Med Sci

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Osteosarcoma is the most common malignant bone tumor characterized by the formation of disorganized immature bone or osteoid tissue from mesenchymal tumor cells. It most commonly occurs in the appendicular skeleton involving the metaphysis of long bones. It is the third most common cancer in adolescence with an annual incidence of 5.6 cases per million children under the age of 15 years. Giant cell-rich osteosarcoma (GCRO) is an exceedingly rare histological variant of conventional primary osteosarcoma. It constitutes about 1%-3% of all osteosarcomas. A 20-year-old male presented with the complaints of pain and swelling over the right knee. Examination revealed a tender 15×10×8 cm swelling palpable on the distal femur. Radiological investigations showed features suggesting right femoral osteosarcoma in the meta-epiphyseal region. A core needle biopsy from the lesion was performed and 15 ml of fluid obtained from the biopsy site was sent for cytological examination, which showed features suggestive of osteosarcoma. Biopsy showed features of osteosarcoma probably of giant cell rich type confirming the fluid cytology findings. Cell block preparation also revealed giant cell predominance. Osteosarcoma is a bone tumor found in areas of rapid bone turnover, most commonly the distal femur and proximal tibia of adolescent patients. Cytology plays a vital role in diagnosing bone tumors, being a rapid, easy, and minimally invasive outpatient department procedure. Histopathology, since it gives a complete architectural pattern of tissue, remains the gold standard diagnostic tool.

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