Adenoid Cystic Carcinoma (AdCC) is an uncommon malignant epithelial salivary gland neoplasm, which is indolent yet persistent. Intraosseous /central variant of AdCC of the jaw is poorly understood owing to its innocuous clinical presentation thus posing a diagnostic challenge. AdCC is characterized by perineural invasion, late distant metastasis and a high recurrence rate, thus having a major effect on the mortality and morbidity rate. It is often diagnosed at an advanced stage which is chiefly achieved through histological examination and complete clinic-radiological work up. A clinical case of an intraosseous variant of AdCC, involving the mandible of a 49 year old male patient is discussed herewith, encompassing the entire spectrum of clinicopathological, radiological and treatment modalities rendered.
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